Category: 1060810-03-8

Reference of 1060810-03-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1060810-03-8, name is 5-Chloro-2-methylisonicotinic acid. A new synthetic method of this compound is introduced below.

To a CH2Cl2 solution of acid 6-4 (0.8 g) was added EDC (1.3 eq) and aniline (2 eq) at room temperature. After 10 minutes, the reaction was diluted with CH2Cl2 and washed with dilute HCl. The organic layer was dried and concentrated to yield amide 6-5 (0.9 g, 80%) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060810-03-8, 5-Chloro-2-methylisonicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; BIOTA SCIENTIFIC MANAGEMENT PTY LTD; WO2008/141385; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1060810-03-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1060810-03-8, name is 5-Chloro-2-methylisonicotinic acid. A new synthetic method of this compound is introduced below.

To a CH2Cl2 solution of acid 6-4 (0.8 g) was added EDC (1.3 eq) and aniline (2 eq) at room temperature. After 10 minutes, the reaction was diluted with CH2Cl2 and washed with dilute HCl. The organic layer was dried and concentrated to yield amide 6-5 (0.9 g, 80%) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060810-03-8, 5-Chloro-2-methylisonicotinic acid, and friends who are interested can also refer to it.

Reference:
Patent; BIOTA SCIENTIFIC MANAGEMENT PTY LTD; WO2008/141385; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem