27-Sep-21 News Some scientific research about 1060811-62-2

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060811-62-2, 4,6-Dichloronicotinaldehyde.

Electric Literature of 1060811-62-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1060811-62-2, name is 4,6-Dichloronicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 2,6-difluoro-3,5-dimethoxyaniline (9.03 g, 47.7 mmol), sodium triacetoxyborohydride (38.0 g, 180 mmol) in methylene chloride (60 mL)/trifluoroacetic acid (30. mL) at room temperature was added slowly a solution of 4,6-dichloronicotinaldehyde (8.00 g, 45.5 mmol) in methylene chloride (10 mL). After stirring at room temperature for 1 hour, the reaction mixture was concentrated under vacuo then saturated aqueous NaHCO3 (200 mL) was added. The resulting mixture was extracted with DCM (3×150 mL). The organic layers were combined, dried over Na2SO4, and concentrated. The residue was purified on silica gel (eluting with 0 to 40percent EtOAc in hexanes) to afford the desired product. LC-MS calculated for C14H13Cl2F2N2O2[M+H]+ m/z: 349.0. found 349.1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060811-62-2, 4,6-Dichloronicotinaldehyde.

Reference:
Patent; Incyte Corporation; Wu, Liangxing; Lu, Liang; Qian, Ding-Quan; Shen, Bo; Yao, Wenqing; (40 pag.)US2016/115164; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 4,6-Dichloronicotinaldehyde

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060811-62-2, 4,6-Dichloronicotinaldehyde, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1060811-62-2, name is 4,6-Dichloronicotinaldehyde, molecular formula is C6H3Cl2NO, molecular weight is 176, as common compound, the synthetic route is as follows.Formula: C6H3Cl2NO

A pre-mixed stirred solution of compound 3 (7.4 g, 42.28 mmol) in dichloromethane (40 mL) containing triethyl amine (11.37 mL, 84.56 mmol) was added ethyl mercaptoacetate (5.59 mL, 50.74 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 1 h and then to 50 °C for 18 h. The reaction mixture was quenched with water and extracted with ethyl acetate. After usual standard work up procedure and purification by column chromatography (silica gel: 100-200 mesh, eluent: 5percent ethyl acetate in pet ether) isolated compound 4; Light Yellow solid; Yield: 5.7 g, 56 percent; m.p.: 108-112 °C. Elemental analysis of C10H8NO2SCl calcd. (found) percent: C 49.69 (49.71), H 3.34 (3.32), N 5.80 (5.77)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060811-62-2, 4,6-Dichloronicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Sree Lakshmana Rao; Basaveswara Rao, Mandava V.; Prasad; Asian Journal of Chemistry; vol. 31; 3; (2019); p. 627 – 632;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 4,6-Dichloronicotinaldehyde

According to the analysis of related databases, 1060811-62-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 1060811-62-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1060811-62-2, name is 4,6-Dichloronicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 4,6-dichloronicotinaldehyde (3 x 1.0 g, 1.0 eq) in DME (3 x 14 mL), hydrazine hydrate (3 x 1.14 g, 4.0 eq, 99percent) was added slowly in a vial. The vial was sealed and the contents heated at 75°C for 16 h. After TLC showed completion, the mixture was cooled to rt and diluted with water (3 x 10 mL) and EtOAc (3 x 10 mL). After combining all 3 mixtures, the layers were separated and the organic layer was washed with brine (20 mL), dried over anhydrous sodium sulphate, filtered and concentrated. The resulting crude was purified by flash chromatography (Combiflash® – Redisep, 12 g) using MeOH in DCM as eluent. The desired product was eluted at 1percent MeOH in DCM. The fractions with product were concentrated to obtain pure 6-chloro- lH-pyrazolo[4,3-c]pyridine as yellow solid (1.4 g, 53.43percent, from 3 batches). 1H NMR (400 MHz, DMSO-d6): delta 13.608 (s, 1H), 8.946 (s, 1H), 8.350 (s, 1H), 7.652 (s, 1H). LCMS calculated for (M) 423.15 and found (M+H) 424.23.

According to the analysis of related databases, 1060811-62-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASANA BIOSCIENCES, LLC; VENKATESAN, Aranapakam M.; SMITH, Roger A.; THOMPSON, Scott K.; LAPING, Nicholas; KULKARNI, Bheemashankar; HALLUR, Gurulingappa; VISWANADHAN, Vellarkad N.; PENDYALA, Muralidhar; KETHIRI, Raghava Reddy; TYAGI, Rajiv; SIVANANDHAN, Dhanalakshmi; BAKTHAVATCHALAM, Rajagopal; WO2015/38417; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Simple exploration of 4,6-Dichloronicotinaldehyde

The chemical industry reduces the impact on the environment during synthesis 1060811-62-2, I believe this compound will play a more active role in future production and life.

Synthetic Route of 1060811-62-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1060811-62-2, name is 4,6-Dichloronicotinaldehyde, molecular formula is C6H3Cl2NO, molecular weight is 176, as common compound, the synthetic route is as follows.

To a reaction vessel containing a mixture of 4,6-dichloronicotinaldehyde (300 g, 1.7 mol) in 1,4- dioxane (1200 mL) was added hydrazine (50%> in water)(360 mL, 3.6 mol). The reaction vessel was sealed and heated at 150 C over 18 h. The mixture was cooled to room temperature, concentrated in vacuo, poured over water and filtered. The filter cake was washed with 20%> EtOAc in hexanes and dried to afford 6-chloro-lH-pyrazolo[4,3-c]pyridine (101.4 g, 38 %>) as a light-yellow solid. LCMS (ESI) [M+H]+ = 154.

The chemical industry reduces the impact on the environment during synthesis 1060811-62-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; DIEDERICH, Francois; DOTSON, Jennafer; HANAN, Emily; HEFFRON, Timothy; LAINCHBURY, Michael; HEALD, Robert; SEWARD, Eileen M.; WO2014/210354; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A new synthetic route of 4,6-Dichloronicotinaldehyde

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1060811-62-2, 4,6-Dichloronicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1060811-62-2, Adding some certain compound to certain chemical reactions, such as: 1060811-62-2, name is 4,6-Dichloronicotinaldehyde,molecular formula is C6H3Cl2NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1060811-62-2.

Step B: 2-(4,6-difluoropyridin-3 -yl)-6-(trifluoromethyl)- 1 -H-benzimidazoleA solution of 4-(trifluoromethy)benzene-l ,2-diamine (250 mg, 1.419 mmol) in DMF (5.0 ml) and water (0.5 ml) was treated with the Intermediate from Step A (250 mg, 1.419 mmol) slowly and the mixture stirred at room temperature for 5 min. Potassium peroxymonosulfate (873 mg, 1.419 mmol) was then added and the mixture stirred for another 50 min. The mixture was poured slowly in 75 ml of water containing 6 ml (2 M K2CO3) and the mixture stirred at room temperature for 5 min. The mixture was diluted with EtOAc and the layers separated. The organic layer was dried (MgS04) and concentrated under vacuum. The resulting residue was then purification on the ISCO CombiFlash Companion (with a 24 g column) eluting with 20 to 40 percent ethylacetate / hexane gradient The desired fractions were concentrated to afford the title compound. LC-MS (ES> m/z) C13H6CI2F3N3: 332; Found: 332, 334, 336 [M, M+2.M+4].’HNMR (500 MHz, COCh, ppm) delta 7.58 (1H, s), 7.66 (1H, d, 8.5 Hz), 7.84 (1 H, d, 8.4 Hz), 8.08 (1H, s), 9.37 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1060811-62-2, 4,6-Dichloronicotinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; BALKOVEC, James, M.; KRIKORIAN, Arto, D.; GUIADEEN, Deodial; YANG, Ginger; JIAN, Tianying; WU, Zhicai; YU, Yang; NARGUND, Ravi, P.; VACHAL, Petr; DEVITA, Robert, J.; HE, Shuwen; LAI, Zhong; BLEVIS-BAL, Radhika, M.; CERNAK, Timothy, A.; SPERBECK, Donald, M.; HONG, Qingmei; WO2012/96813; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The origin of a common compound about 4,6-Dichloronicotinaldehyde

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060811-62-2, 4,6-Dichloronicotinaldehyde, and friends who are interested can also refer to it.

Related Products of 1060811-62-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1060811-62-2, name is 4,6-Dichloronicotinaldehyde. A new synthetic method of this compound is introduced below.

To a stirred solution of 2,6-difluoro-3,5-dimethoxyaniline (9.03 g, 47.7 mmol), sodium triacetoxyborohydride (38.0 g, 180 mmol) in methylene chloride (60 mL)/ trifluoroacetic acid (30. mL), 4,6-dichloronicotinaldehyde (8.00 g, 45.5 mmol) was added in small portions at room temperature. After 1 hour, the volatiles were removed in vacuo and saturated aqueous NaHCO3 (200 mL) was added. The resulting mixture was extracted withDCM (3 xl 50 mL). The organic layers were combined, dried over Na2SO4, and concentrated. The residue was purified on silica gel (eluting with 0 to 0-40percent EtOAc in hexanes) to affordthe desired product (15.0 g). LC-MS calculated for C14H13C12F2N202 [M+H] mlz: 349.0; found 349.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060811-62-2, 4,6-Dichloronicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; INCYTE CORPORATION; LU, Liang; SHEN, Bo; SOKOLSKY, Alexander; WANG, Xiaozhao; WU, Liangxing; YAO, Wenqing; YE, Yingda; (217 pag.)WO2016/134320; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem