Category: 1060812-84-1

Application of 1060812-84-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1060812-84-1, name is 5-Bromopyrazolo[1,5-a]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 5-bromopyrazolo[1,5-alpyridine (0.15 g, 761.30 pmol), 1-[4-(4,4,5,5- tetramethyl- 1,3 ,2-dioxaborolan-2-yl)phenyllcyclopropanecarbonitrile (245.88 mg, 913.56 jimol), Pd(t-Bu3P)2 (58.36 mg, 114.19 pmol) and K3P04 (323.20 mg, 1.52 mmol) in dioxane (2 mL) and H20 (0.2 mL) was stirred at 80 C for 16 hours. The crude product was cooled to r.t., dilutedwith H20 (10 mL), extracted with EtOAc (30 mL x 2). The combined organic phase was washed with brine (10 mL), dried over Na2504, filtered and concentrated to give the crude product. The crude product was purified by silica gel column (PE: EtOAc = 10:1 to 5:1 to 1:1) to give 1 -(4- pyrazolo[1,5-alpyridin-5-ylphenyl)cyclopropanecarbonitrile (150 mg, 76% yield) as a solid. ?H NMR (400 MHz, CDC13) 011 8.53 (d, 1H), 7.99 (d, 1H), 7.72 (d, 1H), 7.64 (d, 2H), 7.41 (d, 2H),7.00 (dd, 1H), 6.58 (d, 1H), 1.83 – 1.78 (m, 2H), 1.50 – 1.46 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1060812-84-1, 5-Bromopyrazolo[1,5-a]pyridine.

Reference:
Patent; PRAXIS PRECISION MEDICINES, INC.; REDDY, Kiran; MARTINEZ BOTELLA, Gabriel; GRIFFIN, Andrew Mark; MARRON, Brian Edward; (168 pag.)WO2018/98500; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1060812-84-1, 5-Bromopyrazolo[1,5-a]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H5BrN2, blongs to pyridine-derivatives compound. COA of Formula: C7H5BrN2

200 mg of compound 21 was suspended in 1 ml of sulfuric acid,Cool to 0 C. A 0.5 ml sulfuric acid / 0.5 ml nitric acid mixture was added dropwise, and the mixture was stirred at 0 C for 30 minutes. TLC detection,After the reaction, pour into ice water and stir for 10 minutes.160 mg of white solid was obtained by suction filtration.Used directly in the next reaction.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1060812-84-1, 5-Bromopyrazolo[1,5-a]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Beijing Fulong Kangtai Biological Co., Ltd.; Ji Qi; Gao Congmin; Wang Lei; Gong Longlong; Chen Bo; Du Zhenjian; (21 pag.)CN110857304; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1060812-84-1 ,Some common heterocyclic compound, 1060812-84-1, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution mixture of 5-bromopyrazolo[1 ,5-a]pyridine 94-2 (900 mg, 4.59 mmol) and tBuONa (661 .2 mg, 6.88 mmol) in toluene (10 mL) was degassed with argon for about 10 mm. To this mixture were added Pd2(dba)3 (84 mg, 0.091 mmol), BINAP (114.2 mg, 0.lO2mmol) and cyclopropylamine (2 mL, 28.87 mmol) under argon atmosphere. The resulting reaction mixture was maintained at 90C for 2 h under microwave irradiation. The reaction mixture was diluted with water (30 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic layer was washed with water (30 mL), brine (25 mL), dried over anhydrous Na2SO4 and concentrated. The crude product was purified by column chromatography over silica-gel (100-200 mesh) using a solvent gradient of 25% ethyl acetate in pet-ether to afford 500 mg (62%) of N-cyclopropylpyrazolo[1,5-a]pyridin-5- amine 147-1 as a brown solid. 1H-NMR (400 MHz, CDCI3): c58.18 (d, J= 7.5 Hz, 1H), 7.78 (d, J= 2.2 Hz, 1H), 6.72 (d, J= 2.6 Hz, 1H), 6.15-6.18 (m, 2H), 4.28 (5, 1H), 2.44-2.49 (m, 1 H), 0.78-0.80 (m, 2H), 0.54-0.58 (m, 1 H). ESI-LC/MS: m/z 173.75 (M+H); R =1 .99 mm [Waters Acquity UPLC with Quattro-micro detector; Waters Acquity BEH Cl 8,1.7 pm, 2.1 X 50 mm column; gradient of 90:10 H20 (0.025% TEA): CH3CN (0.025% TEA) hold for 0.5 mm and to 10:90 H20 (0.025% TEA):CH3CN (0.025% TEA) in 3.5 mm and hold for 1 .5 mm with flow rate of 0.4 mLlmin].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1060812-84-1, its application will become more common.

Reference:
Patent; IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; KONDREDDI, Ravinder Reddy; LEONG, Seh Yong; MISHRA, Pranab Kumar; MOREAU, Robert Joseph; ROLAND, Jason Thomas; SIM, Wei Lin Sandra; SIMON, Oliver; TAN, Liying Jocelyn; YEUNG, Bryan KS; ZOU, Bin; BOLLU, Venkatataiah; WO2014/78802; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem