Category: 1061357-87-6

Adding a certain compound to certain chemical reactions, such as: 1061357-87-6, 6-Bromo-4-iodonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1061357-87-6, blongs to pyridine-derivatives compound. Recommanded Product: 1061357-87-6

To a solution of intermediate 27A (060 g, 1.94 mmol) in a mixture of toluene (10 mL) and water (2 mL) was added cyclopropylboronic acid (0.20 g, 2.33 mmoi) followed by K3P04 (0.82 g. 3.88 mmol) and the resulting mixture was degassed for 15 minutes, Palladium(I1) acetate (0.05 g, 0.19 mmol) and tricyclohexylphosphine (0.11 g, 0.39 rnrnol) ware added. The resultingmixture was degassed again for 10 minutes and heated at 140 C for I h in the microwave. The reaction mixture was cooled to ambient temperature and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep-J2 g, 15-20% EtOAc/n-Hexanes) to obtain Intermediate 27 (010 g, 2308%) as a yellow solid. ?H NMR (400 MHz, DMSO-d6) ppm 0.93 1.02 (rn, I H), 1.04 1.13 (m. 1 H), 1.19 1.35 (m, 2 H), 2.05 221 (rn, I H), 851 (s, I H), 8.75 (s, I H). LCMS Method-D):retention time 2.25 mi [M4-2H1 223.0.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1061357-87-6, 6-Bromo-4-iodonicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1061357-87-6, name is 6-Bromo-4-iodonicotinonitrile. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Bromo-4-iodonicotinonitrile

To a solution of Intermediate 10A (0.60 g, 1.94 mmol) in a mixture of toluene (10 mL) and water (2 mL) was added cyclopropylboronic acid (0.20 g, 2.33 mmol) followed by K3PO4 (0.82 g, 3.88 mmol) and the resulting mixture was degassed for 15 minutes. Palladium(II) acetate (0.05 g, 0.19 mmol) and tricyclohexylphosphine (0.11 g, 0.39 mmol) ware added. The resulting mixture was degassed again for 10 minutes and heated at 140 C for 1 h in the microwave. The reaction mixture was cooled to ambient temperature and filtered through Celite. The filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep12 g, 1520% EtOAc/nHexanes) to obtain Intermediate 10 (0.10 g, 23.08 %) as a yellow solid. 1H NMR (400 MHz, DMSOd6) G^ppm 0.93 1.02 (m, 1 H), 1.04 1.13 (m, 1 H), 1.19 1.35 (m, 2 H), 2.05 2.21 (m, 1 H), 8.51 (s, 1 H), 8.75 (s, 1 H). LCMS (MethodD): retention time 2.25 min, [M+2H] 223.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1061357-87-6, 6-Bromo-4-iodonicotinonitrile.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YADAV, Navnath Dnyanoba; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; GUNAGA, Prashantha; PANDA, Manoranjan; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (444 pag.)WO2018/222795; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem