1064783-29-4 | Pyridine-derivatives

Some tips on 1064783-29-4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1064783-29-4, name is 5-Chloro-3-fluoro-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Chloro-3-fluoro-2-nitropyridine

To the solution of 229 (100 mg, 0.39 mmol) in dried THF (10mL) was added t-BuOK (44 mg, 0.39 mmol) . The mixture was stirred at room temperature for 10min, then was added 2-nitro-3-fluoro-5-chloropyridine (69 mg, 0.39 mmol) and continued to stirred at room temperature for 1h. The reaction was quenched with silica gel (1g) , and purified by column chromatography to give the desired product (153 mg, 95%) .

Reference:
Patent; FUJIAN HAIXI PHARMACEUTICALS CO., LTD; FENG, Yan; WANG, Ruyong; LI, Junqing; ZHENG, Jianjia; LIAN, Xin; GONG, Xuan; FU, Yueli; KANG, Xinshan; (144 pag.)WO2019/174601; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 1064783-29-4

The important role of 5-Chloro-3-fluoro-2-nitropyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, other downstream synthetic routes, hurry up and to see.

Electric Literature of 1064783-29-4, Adding some certain compound to certain chemical reactions, such as: 1064783-29-4, name is 5-Chloro-3-fluoro-2-nitropyridine,molecular formula is C5H2ClFN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1064783-29-4.

A vial was charged with 5-chloro-3-fluoro-2-nitropyridine (1 equiv), methyl 2-(morpholin-3-yl)acetate hydrochloride (1.1 equiv), DMF (0.4 M), and triethylamine (3 equiv). The vial was sealed and heated to 80 C for 7 h. The mixture was cooled, then diluted with 1N aq. HC1 and extracted with EtOAc (3x). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated. The residue was dissolved in acetic acid (0.2 M). Iron (10 equiv) was added, and the resulting mixture was heated to 110 C overnight. The mixture was cooled to room temperature, diluted with EtOAc and filtered through celite. The filter pad was washed successively with EtOAc, DCM, and 20% MeOHIDCM. The combined filtrate was concentrated. The residue was suspended between sat. aq. sodium bicarbonate and EtOAc. The layers were separated, and the aq. layer was extracted with EtOAc (4x). The combined organic extracts were dried over sodium sulfate, filtered, and concentrated. The residue was purified by chromatography on silica gel (40-90% EtOAc/heptane) to give l0-chloro-4,4a,5,7-tetrahydro- 1H-[ 1 ,4]oxazino[4,3 -d]pyrido[2,3 -b] [1 ,4]diazepin-6(2H)-one (54% yield) as awhite solid. ?HNMR (400 MHz, DMSO-d6) ppm 10.12 (s, 1 H) 8.05 (d, J=2.20 Hz, 1H)7.57(d,J=2.2OHz, 1H)3.75-3.88(m,2H)3.36-3.53(m,3H)3.16-3.29(m, 1H)2.96 (br d, J=ll.13 Hz, 1 H) 2.60-2.69 (m, 1 H) 2.02 (d, J=13.69 Hz, 1 H). LCMS (m/z)(M+H) = 254.0, Rt = 0.89 mm.

Reference:
Patent; NOVARTIS AG; AVERSA, Robert John; BURGER, Matthew T.; DILLON, Michael Patrick; DINEEN JR., Thomas A.; KARKI, Rajesh; RAMURTHY, Savithri; RAUNIYAR, Vivek; ROBINSON, Richard; SARVER, Patrick James; (374 pag.)WO2017/103824; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 5-Chloro-3-fluoro-2-nitropyridine

The synthetic route of 1064783-29-4 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H2ClFN2O2, blongs to pyridine-derivatives compound. Computed Properties of C5H2ClFN2O2

5-chloro-3-fluoro-2-nitropyridine (510 mg), 1-amino-2-methylpropan-2-ol (283 mg)A mixture of diisopropylethylamine (1.1 mL) and NMP (3 mL) was stirred at room temperature for 15 h. Water was added to the reaction solution, and the resulting solid was collected by filtration and washed with water and hexane to prepare compound 11 (370 mg).

The synthetic route of 1064783-29-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dainippon Sumitomo Pharma Co., Ltd.; Komiya, Masafumi; Mizushima, Shingo; Iwamoto, Kohei; Urashima, Kuniko; (48 pag.)JP2018/154562; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about 5-Chloro-3-fluoro-2-nitropyridine

The synthetic route of 1064783-29-4 has been constantly updated, and we look forward to future research findings.

New downstream synthetic route of 5-Chloro-3-fluoro-2-nitropyridine

Related Products of 1064783-29-4 ,Some common heterocyclic compound, 1064783-29-4, molecular formula is C5H2ClFN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Chloro-3-fluoro-2-nitropyridin (190.0 mg, 1.08 mmol) and hydrazine monohydrate (80.0 muL, 1.61 mmol) were dissolved in EtOH (3.0 mL) and the mixture was stirred at room temperature for 2 hours. Et2O was added thereto to form a solid, and the formed solid was filtered to obtain orange solid compound of 5-chloro-3-hydrazinyl-2-nitropyridine (170.0 mg, 84%). [1074] 1H-NMR (300 MHz, DMSO-d6); delta: 9.06 (brs, 1H), 8.10 (m, 1H), 7.76 (d, 1H, J=2.4 Hz)

Reference:
Patent; C&C RESEARCH LABORATORIES; Ho, Pil Su; Yoon, Dong Oh; Han, Sun Young; Lee, Won Il; Kim, Jung Sook; Park, Woul Seong; Ahn, Sung Oh; Kim, Hye Jung; US2014/315888; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 5-Chloro-3-fluoro-2-nitropyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Chloro-3-fluoro-2-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Chloro-3-fluoro-2-nitropyridine

5-Chloro-3-fluoro-2-nitropyridine (1 equiv) was dissolved into of anhydrous DIVIF (0.182 M) along with methyl 2-(1 ,4-oxazepan-5-yl)acetate (1.1 equiv) and triethylamine (3 equiv). The mixture was heated to 80 C under an atmosphere of nitrogen with reflux condenser and stirring overnight. After 16 hours the reaction was poured into H20 and extracted three times with EtOAc. Organics were combined, washed with brine, and dried anhydrous Na2SO4. The volatiles were removed and the residue was purified by flash column chromatography over silica gel, eluting with heptane and 0-40% EtOAc gradient to give a yellow oil methyl 2-(4-(5 -chloro-2-nitropyridin-3 -yl)- 1 ,4-oxazepan-5 -yl)acetate in 54.4% yield. LCMS (m/z) (M+H) = 330.1, Rt = 0.91 mm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, and friends who are interested can also refer to it.

Brief introduction of 5-Chloro-3-fluoro-2-nitropyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Chloro-3-fluoro-2-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Chloro-3-fluoro-2-nitropyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1064783-29-4, 5-Chloro-3-fluoro-2-nitropyridine, and friends who are interested can also refer to it.

Share a compound : 5-Chloro-3-fluoro-2-nitropyridine

With the rapid development of chemical substances, we look forward to future research findings about 1064783-29-4.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1064783-29-4, name is 5-Chloro-3-fluoro-2-nitropyridine, molecular formula is C5H2ClFN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1064783-29-4

Compoud 271 (135 mg, 0.5 mmol) was dissolved in dry THF (15 mL) , and sodium hydride (60%, 24 mg, 0.6 mmol) was added at 0. The suspention was stirred for 10 minutes, then 33 (88 mg, 0.5 mmol) was added. The reaction mixture was stirred at room temperature for overnight, and then poured into brine. The resulting mixture was extracted with ethyl acetate. The combined organic layers were dried with anhydrous sodium sulfate, filtered and concentrated. The crude was purified by column chromatography to give light yellow solid (100 mg, 47%) . [0576] The obtained solid (100 mg, 0.24 mmol) was redissolved in methanol (10 mL) , and anhydrous ferric chloride (6 mg) , activated carbon (20 mg) was added. The mixture was refluxed for 15 minutes, then hydrazine hydrate (80%aqueous solution) (0.1 mL) was added dropwise. The resulting mixture was refluxed for 1 h, then poured into brine, and extracted with EA for three times. The combined organic layers were washed with brine once, dried with anhydrous sodium sulfate. The solvent was removed under reduced pressure and the crude was purified by column chromatography to give white solid (85 mg, 89%) .

With the rapid development of chemical substances, we look forward to future research findings about 1064783-29-4.

Share a compound : 5-Chloro-3-fluoro-2-nitropyridine

With the rapid development of chemical substances, we look forward to future research findings about 1064783-29-4.