Electric Literature of 106651-81-4 ,Some common heterocyclic compound, 106651-81-4, molecular formula is C7H9Cl2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-(2-Methoxycarbonylethyl)adenine (313 mg, 1.51 mmol) obtained by Reference example 22 and potassium carbonate (0.44 g, 3.18 mmol) were added to DMF (40 ml). The mixture was at 70C for 1 hour and then cooled to room temperature. Thereto was added 6-methyl-3-pyridylmethyl chloride hydrochloride (0.38 g, 2.13 mmol) and the mixture was stirred at room temperature for 15 hours. After removing the solvent, the residue was poured into water and extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate and concentrated. The residue was purified by column chromatography (SiO2 20g, eluting solvent: CHCl3/MeOH = 100/1 ~ 30/ 1) to give the captioned compound (358 mg, 1.15 mmol) as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 106651-81-4, 5-(Chloromethyl)-2-methylpyridine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1550662; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem