Category: 106850-34-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106850-34-4, name is Imidazo[1,2-a]pyridine-6-carbonitrile, the common compound, a new synthetic route is introduced below. name: Imidazo[1,2-a]pyridine-6-carbonitrile

Nitrogen was bubbled for five minutes into a stirred mixture of 2-chloro-4- methoxypyrimidine (1.14 g, 7.9 mmol), imidazo[1 ,2-a]pyridine-6-carbonitrile (Preparation 1 , 0.75 g, 5.2 mmol), potassium carbonate (1.45 g, 10.5 mmol) and triphenylphosphine (0.55 g, 2.1 mmol) in 1 ,4-dioxane (10 mL) and ethanol (5 mL) in a microwave vessel. Then palladium (II) acetate (0.24 g, 1.1 mmol) was added and the vessel was sealed and subjected to microwave irradiation for 2 hours at 150 C. The reaction was repeated 5 further times under the same conditions and the six experiments were combined and the solvent was evaporated. The residue was taken up in a mixture of ethyl acetate and water and filtered to remove an insoluble black solid. The organic layer was separated and extracted with 2M aqueous hydrochloric acid (3 x 80 mL). The combined aqueous layer was washed with diethyl ether and then treated with solid sodium hydrogencarbonate until a pH of approximately 6 was reached. The solid that formed was filtered and dried in vacuum to give a first crop of the title compound (2.65 g). The insoluble black solid was treated with 2M aqueous hydrochloric acid (2 x 60 mL) and filtered. The aqueous solution was treated with solid sodium hydrogencarbonate until a pH of approximately 6 was reached. The solid that formed was filtered and dried in vacuum to give a second crop of the title compound (0.77 g). Total yield = 3.42 g (43%).LRMS (m/z): 252 (M+1)+.1H-NMR delta (DMSO-cfe): 4.08 (s, 3H), 6.88 (d, 1 H), 7.76 (dd, 1 H), 7.95 (dd, 1 H), 8.63 (s, 1 H), 8.67 (d, 1 H), 10.39 (bs, 1 H).

The synthetic route of 106850-34-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; BACH TANA, Jordi; PAGES SANTACANA, Lluis Miquel; TALTAVULL MOLL, Joan; CATURLA JAVALOYES, Juan Francisco; MATASSA, Victor Giulio; WO2011/76419; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106850-34-4, Imidazo[1,2-a]pyridine-6-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 106850-34-4, blongs to pyridine-derivatives compound. Safety of Imidazo[1,2-a]pyridine-6-carbonitrile

EXAMPLE 93 7beta-[2-(5-Amino-1,2,4-thiadiazol-3-yl)-2(Z)-ethoxyiminoacetamido]-3-[(6-cyanoimidazo[1,2-a]pyridinium-1-yl)methyl]-3-cephem-4-carboxylate STR150 The compound obtained in Reference Example 28 is reacted with 6-cyanoimidazo[1,2-a]pyridine in the procedure of Example 42 to give the above-identified compound. Elemental analysis for C22 H19 N9 O5 S2.4H2 O: Calcd. (%): C, 42.24; H, 4.35; N, 20.15. Found (%): C, 42.12; H, 3.90; N, 19.97. IR spectrum numaxKBr cm-1: 2250, 1760, 1620, 1525. NMR spectrum (d6 -DMSO)delta: 1.19(3H, t, J=7 Hz), 2.98 and 3.44 (2H, ABq, J=18 Hz), 4.12 (2H, q, J=7 Hz), 5.00 (1H, d, J=5 Hz), 5.1-5.6 (2H, m), 5.66 (1H, d. d, J=5 Hz & 8 Hz), 8.10 (2H, br. s), 8.2-9.0 (4H, m), 9.42 (1H, d, J=8 Hz), 9.76 (1H, br. s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,106850-34-4, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4788185; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 106850-34-4 , The common heterocyclic compound, 106850-34-4, name is Imidazo[1,2-a]pyridine-6-carbonitrile, molecular formula is C8H5N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

An oven dried resealable Schlenk tube was charged with imidazo[1 ,2-a]pyridine-6- carbonitrile (Preparation 1 , 0.30 g, 2.1 mmol), N-benzyl-2-chloro-N-methylpyrimidin-4- amine (Preparation 31 , 0.24 g, 1.0 mmol), potassium acetate (0.21 g, 2.1 mmol) and Lambda/,Lambda/’-dimethylacetamide (3 mL). The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon then tetrakis(triphenylphosphine)palladium (0) (0.12 g, 0.10 mmol) was added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and placed in an oil bath at 150 C and the mixture was stirred overnight. The mixture was evaporated in vacuum and the residue was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried (MgS04) and evaporated and the residue was purified by flash chromatography (99:1 to 98:2 dichloromethane/methanol) to give the title compound (0.105 g, 30%) as a pale brown solid.LRMS (m/z): 341 (M+1)+.1H-NMR delta (CDCI3): 3.22 (bs, 3H), 4.91 (bs, 2H), 6.40 (d, 1 H), 7.27 – 7.41 (m, 6H), 7.76 (dd, 1 H), 8.31 (d, 1 H), 8.59 (s, 1 H), 10.49 (bs, 1 H)

The synthetic route of 106850-34-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; BACH TANA, Jordi; PAGES SANTACANA, Lluis Miquel; TALTAVULL MOLL, Joan; CATURLA JAVALOYES, Juan Francisco; MATASSA, Victor Giulio; WO2011/76419; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem