Category: 106877-33-2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine, the common compound, a new synthetic route is introduced below. Quality Control of 5-Amino-2-(trifluoromethyl)pyridine

6-trifluoromethyl-pyridin-3-ylamine (0.25 g, 1 .54 mmol) was added to a mixture of sodium hydride (0.22 g, 9.16 mmol) and N,N-dimethylformamide (2 mL) at 25 – 30 C under nitrogen gas and the reaction mixture was stirred for 15 – 20 min. Compound of example 2 (0.44 g, 1 .7 mmol) was added to the reaction mixture and was stirred for 6 – 8 h. The reaction mixture was cooled to 10 C and methanol (1 .2 mL) was added slowly. A solution of chilled 20 % ammonium chloride solution (10 mL) was added drop-wise to the reaction mixture at 10 C and was stirred for 25 – 30 min. The precipitated product was filtered, and was washed with water followed by petroleum ether. The resulting product was dried at 45 – 50 C for 20 – 22 h. Yield: 0.4 g (68.96 %); 1H NMR (300 MHz, DMSO-d6): delta 10.28 (s, 1 H), 8.9 (s, 1 H), 8.8 (s, 1 H), 8.58 (d, 1 H, 8.7 Hz), 7.87 (d, 1 H, 8.7 Hz), 7.66 (d, 1 H, 9 Hz), 7.32 (s, 1 H), 7.1 (d, 1 H, 8.4 Hz), 3.86 (s, 6H, 6.3 Hz); MS (ES+): 377 (M+1 ).

The synthetic route of 106877-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIRAMAL ENTERPRISES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana, Sanjay; HARIHARAN, Sivaramakrishnan; BOKKA, Ravishankar; AWARE, Valmik, Sopan; MANOHAR, Sonal; SONAWANE, Vinay; CHENNAMSETTY, Suneelmanoharbabu; KALE, Ganesh; THOMAS, Becky, Mary; TRIVEDI, Jacqueline, Vinodkumar; WO2013/175415; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, molecular weight is 162.11, as common compound, the synthetic route is as follows.name: 5-Amino-2-(trifluoromethyl)pyridine

EXAMPLE 3 [0186] [CHEMMOL-00538] [0187] Step 1 [0188] 3-Amino-6(trifluoromethyl)pyridine (1.0 g, 6.2 mmol), N-Boc-4-piperidone (1.5 g, 7.4 mmol), Na(AcO)3BH (2.0 g, 9.3 mmol), and AcOH (0.35 mL, 6.2 mmol) were taken up in 1,2-dichloroethane and stirred at 55 C. for 17 hours. The solution was diluted with CH2Cl2 and quenched with 1 N NaOH. The aqueous layer was extracted with CH2Cl2. The combined organic layers were dried (Na2SO4), filtered and concentrated to furnish a yellow oil. The residue was resubjected to the reaction conditions for 20 hours. After workup, a yellow oil was obtained. The amine product was purified via recrystallization (CH2Cl2/hexanes) to give 1.6 g (75%) of the amine.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Schering Corporation; US2004/10008; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H5F3N2

(1) Pyridine (2.9 mL) was added to a solution of 2-trifluoromethyl-5-aminopyridine (1.95 g) in chloroform (15 mL), the mixture was cooled in ice, and phenyl chloroformate (1.8 mL) was added thereto. The resulting mixture was stirred at room temperature overnight, and the reaction mixture was concentrated under reduced pressure. The residue was washed with isopropyl ether to afford phenyl[6-(trifluoromethyl)pyridin-3-yl]carbamate (2.16 g). (ESI pos.) m/z: 283 ([M+H]+)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD; Moriya, Minoru; Ohta, Hiroshi; Yamamoto, Shuji; Abe, Kumi; Araki, Yuko; Sun, Xiang-Min; Wakasugi, Daisuke; US2013/331571; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 5-Amino-2-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. Recommanded Product: 5-Amino-2-(trifluoromethyl)pyridine

Example 4; 5-amino-l-(3-(pyrrolidin-l-ylmethyl)benzyl)-7-(trifluoromethyl)pyrMdionePreparation of 2-chloro-6-(trifluoromethyl)pyridin-3-amine (19)[000396] To a solution of 6-(trifluoromethyl)pyridin-3-amine (18) (1 equiv) (commercially available) in CH3CN (0.25M) was added N-cholorosuccinimide (1 equiv) and stirred at 80 C for 2 hours. The mixture was then cooled down to room temperature and concentrated en vaccuo. The residue was purified by Combi-Flash using 0-20% EtOAc in hexane to afford 2-chloro-6- (trifluoromethyl)pyridin- 3 – amine (19).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; IRM LLC; CORTEZ, Alex; LI, Yongkai; LIAO, Xuebin; WU, Tom Yao-Hsiang; ZHANG, Xiaoyue; WO2011/57148; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 106877-33-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

6-(Trifluoromethyl)pyridin-3-amine (int-75) (1.3 g, 8.0 mmol) was dissolved in dichloroethane (50 mL), and N-bromosuccinimide (L4 g, 8.0 mrnoi) was added. The mixture was stirred at rt for 15 h. The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel using a mixture of petroleum ether and EtOAc (20:1) as eluent to give 4-bromo6-(trifiuoromethyi)pyridin3amine (hft76) (1.5 g, 78% yield) as a whfte solid. MS (ESI): mlz 240.7 [M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; ACTAVALON, INC.; DNEPROVSKAIA, Elena V.; HOLZWARTH, Michael S.; (160 pag.)WO2018/81612; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H5F3N2

EXAMPLE 824-(Aminomethyl)-l-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-N-(6-(trifluoromethyl)pyridin-3- yl)piperidine-4-carboxamide82A. ferf-Butyl 4-cvano-4-(6-(trifluoromethyl)pyridin-3-ylcarbamoyl)piperidine- 1 – carboxylate; 6-(Trifluoromethyl)pyridin-3 -amine (319 mg, 1.97 mmol) was added in one portion to 1- (t°t-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid (500mg, 1.97 mmol), HATU (822 mg, 2.16 mmol) and DIPEA (1030 mul, 5.90 mmol) in DMA (9832 mul) at 2O0C under nitrogen. The resulting solution was stirred at 20 0C for 24 hours. The reaction mixture was diluted with EtOAc (10ml), and washed sequentially with water (2 x 10ml) and saturated brine (10ml). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 10 to 50% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford tert-butyl 4-cyano-4-(6-(trifluoromethyl)pyridin-3-ylcarbamoyl)piperidine- 1 – carboxylate (330 mg, 42.1 %) as a white solid .IH NMR (400.132 MHz, DMSO) delta 1.42 (9H, s), 1.97 – 2.05 (2H, m), 2.22 (2H, d), 3.00 (2H, s), 4.07 (2H, d), 7.93 (IH, d), 8.34 – 8.36 (IH, m), 8.97 (IH, d), 10.72 (IH, s)MS m/e MH+ 397

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB; WO2008/75110; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Amino-2-(trifluoromethyl)pyridine

Oxalylchloride (132 muL, 1.5 mmol) was added dropwise to a stirred suspension of benzoicacid 124 (350 mg, 1.0 mmol) and DMF (1 drop) in dry THF (20 mL) and thesolution was stirred at 20 C. for 2 h, then at 66 C. for 1 h. The solutionwas cooled to 20 C., then the solvent was evaporated and the residue dissolvedin dry pyridine (10 mL). 6-Trifluoromethyl-3-pyridinylamine (180 mg, 1.1 mmol)was added and the solution stirred at 20 C. for 16 h. The solvent wasevaporated and the residue suspended in ice/water (50 mL) for 1 h. Theprecipitate was filtered, washed with water (5 mL) and dried. The crude solidwas purified by column chromatography, eluting with a gradient (50-100%) ofEtOAc/pet. ether, to give benzamide 136 (268 mg, 54%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; THEBOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLANDUNISERVICES LIMITED; SUTPHIN, PATRICK; CHAN, DENISE; TURCOTTE, SANDRA; DENNY, WILLIAMALEXANDER; HAY, MICHAELPATRICK; GIDDENS, ANNACLAIRE; BONNET, MURIEL; GIACCIA, AMATO; (181 pag.)JP5789603; (2015); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H5F3N2

Example 92:(R)-l-(4-(Trifluoromethyl)phenyl)-N-(6-(trinuoromethyl)pyridin-3-yl)-3,4- dihydroisoquinoline-2(lH)-carboxamide; To a solution of (R)-4-nitrophenyl l-(4-(trifluoromethyl)phenyl)-3,4-dihydroiso- quinoline-2(lH)-carboxylate (70 mg, 158 mumol, example 88) in MeCN (0.5 mL) was added 3-amino-6-(trifluoromethyl)pyridine (77 mg, 475 mumol). The resulting mixture was then subjected to a microwave irradiation at 150 C for 15 min and at 180 C for 15 min. Then, sodium hydride, 60% dispersion in mineral oil (18 mg, 475 mumol) was added and the mixture was stirred at RT for overnight. Then, H2O (0.5 mL) was added and the solvents were removed. The residue was then dissolved in a solution of MeOH and DMSO (1 :1. 1.0 mL). The solution mixture was purified by preparative HPLC (0%-100% MeCN 0.1% TFA/H2O 0.1% TFA) to give the desired product, which was then dissolved in MeOH (1.0 mL). The solution was then washed through PL-HCO3 MP resin (polymerlabs, 200 mg/6 mL tube) and the resin was washed with MeOH (2 x 0.5 mL). The combined washings were then concentrated and dried under vacuum to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 466 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 106877-33-2.

Reference:
Patent; AMGEN INC.; WO2009/73203; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 106877-33-2, Adding some certain compound to certain chemical reactions, such as: 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine,molecular formula is C6H5F3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106877-33-2.

[0372] A stirred solution of 7-bromo-6-methylquinoline Int-1 (Example 86) (150 mg, 0.675 mmol), 6-(trifluoromethyl)pyridin-3-amine (131 mg, 0.810 mmol) and Na2CC>3 (142 mg, 1.351 mmol) in acetonitrile (5 mL) was degassed with Argon in a microwave vessel for 15 min. Then Mo(CO)6 (178 mg, 0.675 mmol), 3RhoEtaBetaEpsilon4 (19.6 mg, 0.0675 mmol) and Pd(OAc)2 (15.1 mg, 0.0675 mmol) were added, and degassing was continued for additional 10 min. Then the reaction mixture was irradiated in microwave at 90 C for 3 hrs. After completion (checked by TLC), the reaction mixture was diluted with water (20 mL) and extracted with Ethyl Acetate (2×50 mL). Combined organic layer was washed with water (2×20 mL), brine (20 mL) and dried over anhydrous sodium sulfate. The organic layer was evaporated under reduced pressure to afford crude product. The crude compound was purified by Grace (reverse phase) column chromatography using 0.05 % HCOOH in CCN as eluent to afford 50 mg (21% yield) of the desired compound 160 as an off- white solid. MS (ESI) m/z: 332.21 [M+H]+. 1H NMR (DMSO-i/6, 400 MHz): delta 11.18 (s, 1H), 9.07 (d, J = 2.0 Hz, 1H), 8.94 (dd, J = 4.4, 2.0 Hz, 1H), 8.50 (dd, J = 8.0, 1.6 Hz, 1H), 8.35 (dd, J Hz, 1H), 8.24 (s, 1H), 7 ‘.95-7 ‘.92 (m, 2H), 7.60 (dd, J= 8.4, 4.0 Hz, 1H), 2.61 (s, 3H).

According to the analysis of related databases, 106877-33-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTAVALON, INC.; DNEPROVSKAIA, Elena, V.; HOLZWARTH, Michael, S.; RYCHNOVSKY, Scott, D.; (184 pag.)WO2018/85348; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H5F3N2, blongs to pyridine-derivatives compound. Formula: C6H5F3N2

Thionyl chloride (31 mL, 0.43 mol) was slowly added to 175 mL, of water at 0 C. During the addition the temperature was maintained between 0-5 C. After addition the solution was warmed to 15 C. and 0.47 g (4.8 mmol) of CuCl was added. The solution was diluted with 100 mL of water and cooled back to 0 C. A solution of 7.21 g (0.10 mol) of NaNO2 in 100 mL, of water was slowly added to a solution of 15.39 g (0.10 mol) of 5-amino-2-(trifluoromethyl)pyridine (95) in 125 mL of conc. HCl at 0 C. During addition the temperature was maintained between 0-5 C. This mixture was then slowly added to the above prepared solution so as to maintain a temperature between 0-5 C. A voluminous precipitate formed. The mixture was stirred for an additional 30 min after addition and the solid was then collected by filtration. The solid was washed with water and dissolved in CHCl3. The solution was dried over MgSO4, filtered and the solvent was removed to afford 18.03 g (77%) of sulfonyl chloride (83) as a tan solid. 1H NMR (CDCl3) delta 9.34 (d, J=2.2 Hz, 1 H), 8.53 (dd, J=8.4, 2.2 Hz, 1H), 7.98 (d, J=8.4 Hz, 1H).

The synthetic route of 106877-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Konradi, Andrei W.; Probst, Gary; Aubele, Danielle L.; Garofalo, Albert W.; Hom, Roy; Neitzel, Martin L.; Semko, Christopher M.; Truong, Anh P.; US2008/21056; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem