Category: 106984-91-2

Adding a certain compound to certain chemical reactions, such as: 106984-91-2, 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H5NO2, blongs to pyridine-derivatives compound. COA of Formula: C6H5NO2

Synthesis of Example 25: [Show Image] To a solution of intermediate 12e (417 mg, 1.00 mmol) in acetonitrile (20 mL) and acetic acid (200 muL) was added 6-hydroxynicotinaldehyde (123 mg, 1.00 mmol). The reaction mixture was stirred vigorously at reflux temperature overnight. The solvent was removed under reduced pressure. The crude product was purified by preparative LC-MS. The pure product (213 mg, 0.41 mmol, brown sticky solid) was dissolved in methanol (5 mL) and 1 M HCl in diethyl ether (820 muL, 0.82 mmol) was added. The solvents were removed under reduced pressure. The product was taken up in water (5 mL) and lyophilized

The synthetic route of 106984-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2439197; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106984-91-2, 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H5NO2, blongs to pyridine-derivatives compound. COA of Formula: C6H5NO2

Synthesis of Example 25: [Show Image] To a solution of intermediate 12e (417 mg, 1.00 mmol) in acetonitrile (20 mL) and acetic acid (200 muL) was added 6-hydroxynicotinaldehyde (123 mg, 1.00 mmol). The reaction mixture was stirred vigorously at reflux temperature overnight. The solvent was removed under reduced pressure. The crude product was purified by preparative LC-MS. The pure product (213 mg, 0.41 mmol, brown sticky solid) was dissolved in methanol (5 mL) and 1 M HCl in diethyl ether (820 muL, 0.82 mmol) was added. The solvents were removed under reduced pressure. The product was taken up in water (5 mL) and lyophilized

The synthetic route of 106984-91-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2439197; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 106984-91-2, name is 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, molecular formula is C6H5NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 6-Oxo-1,6-dihydropyridine-3-carbaldehyde

A solution of 6-hydroxynicotinaldehyde SM 1(192mg, 4 mmol) and (S)-1-cyclopropylethanamine (170 mg, 2 mmol) in DCM (5 mL) and EtOH (5 mL) was added NaBH3CN(620 mg, 10 mmol), then stirred at RT for 16 h. The resulting reaction mixture was quenched withwater and extracted with DCM, dried and evaporated, purified by combiflash (methanol:DCM =1:20) to give compound 1(300mg, 78%). LC-MS: m/z = 193.1 [M+H]

With the rapid development of chemical substances, we look forward to future research findings about 106984-91-2.

Reference:
Patent; ABBVIE INC.; MICHAELIDES, Michael; HANSEN, Todd; DAI, Yujia; ZHU, Guidong; FREY, Robin; GONG, Jane; PENNING, Thomas; CURTIN, Michael; MCCLELLAN, William; CLARK, Richard; TORRENT, Maricel; MASTRACCHIO, Anthony; KESICKI, Edward A.; KLUGE, Arthur F.; PATANE, Michael A.; VAN DRIE, John H. Jr.; JI, Zhiqin; LAI, Chunqiu C.; WANG, Ce; (1190 pag.)WO2016/44770; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106984-91-2, name is 6-Oxo-1,6-dihydropyridine-3-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 106984-91-2

To a stirred solution of 5-3 (O.lg, 0.3mMol) and triethylamine (0.08mL, 0.5mMol) in NMR (ImL) was added 17-2 (0.03g, 0.3mMol) and acetic acid (0.03mL, 0.5mMol), followed by sodium triacetoxyborohydride (0.12g, 0.5mMol). After stirring overnight at room temperature, the reaction was filtered through a syringe filter and purified on a Cl 8 reverse phase HPLC to yield 17-3 as the HCl salt. Mass (M+l) calculated: 473.2085 observed: 473.2092.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106984-91-2, 6-Oxo-1,6-dihydropyridine-3-carbaldehyde.

Reference:
Patent; MERCK & CO., INC.; WO2006/135627; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.106984-91-2, name is 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, molecular formula is C6H5NO2, molecular weight is 123.11, as common compound, the synthetic route is as follows.Recommanded Product: 6-Oxo-1,6-dihydropyridine-3-carbaldehyde

Example 22: [Show Image] To a solution of intermediate 22b (295 mg, 0.720 mmol) in acetonitrile (20 mL) and acetic acid (200 muL) was added 6-hydroxynicotinaldehyde (87 mg, 0.708 mmol). The reaction mixture was stirred vigorously at reflux temperature overnight. The solvent was removed under reduced pressure. The crude product was purified by preparative LC-MS. The pure product (54 mg, orange oil) was dissolved in methanol (2 mL) and 1 M HCl in diethyl ether (110 muL, 0.110 mmol) was added. The solvents were removed under reduced pressure. The product was taken up in water (3 mL) and lyophilized.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106984-91-2, 6-Oxo-1,6-dihydropyridine-3-carbaldehyde, and friends who are interested can also refer to it.

Reference:
Patent; Santhera Pharmaceuticals (Schweiz) AG; EP2439197; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem