Category: 1072-97-5

1072-97-5, Name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Pour, Ghobad Behzadi, once mentioned the new application about 1072-97-5, Category: pyridine-derivatives.

Polyvinylpyridine (PVPy) is a linearly structured polymer-containing aromatic heterocyclic compound. PVPy is easily prepared via radical polymerization of vinylpyridine using an initiator of azobisisobutyronitrile in which different haloalkanes can be used for the quaternization of pyridine units. The pyridine moieties of the polymer backbone can lead to an enhanced electrical conductivity in this polymeric material. For this reason, this vinyl polymer has been extensively applied in electrode organization for electrochemical applications. Thus, we aimed to review the uses of PVPy in the electrode structure and/or its application for the modification of electrochemical electrodes in systems such as sensors for monitoring and determining humidity and various chemicals.

If you’re interested in learning more about 1072-97-5. The above is the message from the blog manager. Category: pyridine-derivatives.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1072-97-5, 5-Bromopyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1072-97-5, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Example 4 Preparation of compound 8: 1. An ethanol solution of compound 5 (12400 g in 51 L of ethanol) was added to an appropriately sized stainless steel reactor at room temperature under nitrogen atmosphere. 2. Compound 6 (9500 g) was added as a solid in one portion at room temperature. 3. The reaction mixture was heated to reflux (?78C) and stirred for 1-2 days. 4. The reaction was monitored by HPLC. 5. Upon completion, the reaction mixture was allowed to cool to room temperature. 6. NaOH solution (9884 g solid pellets dissolved in 38 L of water) was added as a stream over a 30 min period at an internal temperature below 35 C. 7. The reaction mixture was heated to reflux (?78C) for 3 to 4 hours. 8. The reaction was monitored by HPLC. 9. Upon completion, the reaction mixture was cooled to an appropriate temperature to start solvent removal. 10. All ethanol (approximately 5 volumes of ethanol) was removed under vacuum at 40 to 45 C. 11. The reaction mixture was cooled to room temperature. 12. Water (57 L; 6 vol) was added at room temperature. 13. The aqueous solution was washed with ethyl acetate (2 x 38 L) to remove all organic impurities. 14. The lower aqueous layer was cooled to 0-5 C and acidified with cone. HCl (?15 L) until reaching pH 1-2. 15. The reaction mixture was stirred for 1 to 2 hours at 0 to 5 C. 16. The mixturewas filtered and the cake was washed with water (2 x 38 L) and acetone (2 x 19L) followed by drying for 1-2 hours. 17. The solid collectedwas transferred back into an appropriately sized reactor. 18. Heptane (95 L; 10 vol) was addedto the reactor; the suspension was stirred for 4 to 5 hours at roomtemperature. 19. The solidwas collected by filtration and washed with heptane (2 x 19 L). 20. The solid (15 kg) was suspended in methanol (75 L; 5 vol) at room temperature for 2 hours. 21. The suspension was filtered and the solid collected was washed with methanol (2x 5L). 22. The solid was dried under vacuum at 50C to constant weight to give compound 8 as an off-white to white solid (10169 g, 83.3 % yield; HPLC purity 99.2%;1HNMR (DMSO-d6, 300 MHz) delta 9.4 (s, 1H), 8.3 (s, 1H), 7.85-7.67 (m, 2H)).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1072-97-5, its application will become more common.

Reference:
Patent; IP Gesellschaft fuer Management mbH; Trinius, Frank; EP2792360; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1072-97-5 , The common heterocyclic compound, 1072-97-5, name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Bromo-2-aminopyridine (5.19 g, 30 mmol) was dissolved in 100 mL of anhydrous dichloromethane.20 ml of triethylamine was added. In ice bath conditions,Slowly add acetyl chloride (2.54 ml) to the above solution, after the addition is completed,The ice bath was removed and allowed to warm to room temperature overnight. After the reaction,Dilute with dichloromethane,Washed (30ml × 3), washed with saturated NaHCO3 solution (30ml × 3),The mixture was washed with saturated NaCl (30 mL) and dried over anhydrous Na2SO.Column chromatography to obtain a white solid5.65 g, yield 88%.

The synthetic route of 1072-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Pan Xiaoyan; Liang Liyuan; Lu Wen; Wang Sicen; He Langchong; Si Ru; Wang Jin; (15 pag.)CN109796439; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1072-97-5, name is 5-Bromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H5BrN2

NaH (47.3 mg, 1.971 mmol) and 5-bromo-2-pyridinamine (310 mg, 1.792 mmol, available from Aldrich) were added to N,N-Dimethylformamide (DMF) (7 mL) and stirred in an ice bath for 30 mins. The reaction mixture was then allowed to warm to room temperature and methyl iodide (0.123 mL, 1.971 mmol) was added and the reaction mixture stirred for 24 hr. The reaction mixture was partitioned between DCM (20 mL) and water (20 mL) and the organic layer washed with more water (20 mL) before being dried through an hydrophobic frit and concentrated. The residue was dissolved in DCM and purified by SP4 on a 25+S silica cartridge using a gradient of 10%-40% EtOAc in cyclohexane. Appropriate fractions were collected and concentrated to yield the desired product as a white solid (79.1 mg). LCMS (Method C): Rt 0.39, MH+=187

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1072-97-5, 5-Bromopyridin-2-amine.

Reference:
Patent; Demont, Emmanuel Hubert; Garton, Neil Stuart; Gosmini, Romain Luc Marie; Hayhow, Thomas George Christopher; Seal, Jonathan; Wilson, David Matthew; Woodrow, Michael David; US2012/208798; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1072-97-5, Adding some certain compound to certain chemical reactions, such as: 1072-97-5, name is 5-Bromopyridin-2-amine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-97-5.

5-bromopyridin-2-amine (0.5 g, 2.89 mmol), cyclopropylboronic acid (0.49 g, 5.78 mmol) and K3PO4 (1.84 g, 8.67 mmol) were combined in a mixture of toluene : water (4:1, 10 ml) and the mixture was degassed for 20 minutes with argon gas. To the reaction mixture, palladium acetate (0.032 g, 0.144 mmol) and tricyclo hexyl-phosphine (0.081 g, 0.289 mmol) were added and degassing was continued for another 10 minutes. The reaction mixture was heated in a sealed tube at 100 C for 16 hours. The reaction mixture was diluted with water (15 ml) and extracted with ethyl acetate (2 x 15 ml). The combined organic layers were washed with brine (15 ml), dried over anhydrous Na2S04 and concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford the title compound (0.3 g, 77%) as a solid. 1H NMR (400 MHz, DMSO-d6): d 0.49-0.56 (m, 2H), 0.75-0.83 (m, 2H), 1.70-1.77 (m, 1H), 5.65 (s, 2H, -NH2), 6.36 (d, / = 8.4 Hz, 1H), 7.04 (dd, 7 = 8.4 Hz, 2.0 Hz, 1H), 7.74 (d, / = 1.6 Hz, 1H). LCMS: m/z =135.2 [M+l]

According to the analysis of related databases, 1072-97-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; WILSON, Jonathan, E.; BRUCELLE, Francois; LEVELL, Julian, R.; (153 pag.)WO2019/161162; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1072-97-5, 5-Bromopyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Bromopyridin-2-amine, blongs to pyridine-derivatives compound. Safety of 5-Bromopyridin-2-amine

5-bromo-2-aminopyridine (5.19 g, 30 mmol) was dissolved in 100 mL of anhydrous dichloromethane. 20 ml of triethylamine was added. In ice bath conditions, Slowly add acetyl chloride (2.54 ml) to the above solution. After the addition is complete, Remove the ice bath, The reaction was allowed to rise to room temperature overnight (i.e., reaction for 12 h). After the reaction, Dilute with dichloromethane, Washed (30ml × 3), Wash with saturated NaHCO 3 solution (30ml × 3), Saturated NaCl wash (30ml), The organic phase was dried over anhydrous Na 2 SO 4 . Column chromatography gave 5.65 g of a white solid, yield 88%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-97-5, 5-Bromopyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Pan Xiaoyan; Liang Liyuan; Lu Wen; Wang Sicen; He Langchong; Si Ru; Wang Jin; (15 pag.)CN109734660; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-97-5, name is 5-Bromopyridin-2-amine, the common compound, a new synthetic route is introduced below. Safety of 5-Bromopyridin-2-amine

a) 5-Cyclopropyl-pyridin-2-ylamine; To a solution of 5-bromo-pyridin-2-ylamine (2 g, 11.55 mmol) and cyclopropyl boronic acid (2.98 g, 34.68 mmol) in toluene (40 mL) and water (2 mL) was added K3PO4 (8.59 g, 40.46 mmol) under an argon atmosphere. A balloon containing argon was affixed, and the reaction flask was purged to ensure a argon atmosphere. To this were added Pd(OAc)2, (259.52 mg, 1.16 mmol) and tricyclohexylphosphene (647.3 mg, 2.3 mmol) and stirred at 80 C. for 16 h. The reaction mixture was cooled to room temperature and water was added. The aqueous phase was extracted with ethyl acetate, the combined organic phases were dried over sodium sulfate, the solvent was evaporated and the residue purified by silica gel chromatography using ethyl acetate/hexane as eluent. The title compound was obtained as an off white solid (1.1 g, 71%).1H NMR (DMSO, 400 MHz): delta(ppm)=7.73 (s, 1H), 7.04-7.02 (dd, J=8.48 & 2.04 Hz, 1H), 6.34 (d, J=8.48 & 2.04 Hz, 1H), 5.60 (s, 2H), 1.78-1.66 (m, 1H), 0.822-0.77 (m, 2H), 0.52-0.313 (m, 2H)

The synthetic route of 1072-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Baumann, Karlheinz; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew; US2011/190269; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1072-97-5, name is 5-Bromopyridin-2-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 1072-97-5

5-Bromo-2-aminopyridine (5.19 g, 30 mmol) was dissolved in 100 ml of dry dichloromethane and then 20 ml of triethylamine.Acetyl chloride (2.54 ml) was slowly added dropwise to the above solution under ice-cooling, and after the dropwise addition was completed, the ice bath was removed, and the mixture was allowed to react at room temperature overnight.After completion of the reaction, it was diluted with dichloromethane, washed with water (30 ml × 3), washed with a saturated NaHCO 3 solution (30 ml × 3), washed with saturated NaCl (30 ml), and dried over anhydrous Na2SO4.Column chromatography gave 5.65 g of a white solid, yield 88%

The synthetic route of 1072-97-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xi’an Jiaotong University; Zhang Jie; Pan Xiaoyan; Liang Liyuan; Lu Wen; Wang Sicen; He Langchong; Si Ru; Wang Jin; (15 pag.)CN109761957; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1072-97-5 ,Some common heterocyclic compound, 1072-97-5, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Amino-5-bromopyridine (2) (20 g, 115.6 mmol) was added to a 500-mL three-necked flask at room temperature, followed by the addition of anhydrous ethanol (200 mL) and sodium bicarbonate (24.3 g, 289.0 mmol). Then ethyl 3-bromopyruvate (33.8 g, 173.4 mmol) was slowly added dropwise with stirring. After the completion of the dropwise addition, the reaction mixture was heated to 85 C and refluxed for 8 h. After the reaction completed, the solvent was evaporated to dryness under reduced pressure. Then proper water was added the pH was adjusted to 8 to 9 with sodium hydroxide. The solution was stirred well and filtered. The filter cake was washed with methyl tert-butyl ether (15 mL×3) to obtain 3 (25.1 g, yield 80.6%) as a yellow-brown powder. 1H NMR (400 MHz, chloroform-d) delta 8.32 (s, 1H, Ar-H), 8.16 (s, 1H, Ar-H), 7.61 (d, J = 9.6 Hz, 1H, Ar-H), 7.33 (dd,J = 9.6, 1.8 Hz, 1H, Ar-H), 4.48 (q, J = 7.1 Hz, 2H, -OCH2-), 1.46 (t, J = 7.1 Hz, 3H,-CH3). MS (ESI): m/z 270.0 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1072-97-5, 5-Bromopyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Qin; Long; Zhu; Zhou; Chai; Zhao; Journal of Structural Chemistry; vol. 60; 12; (2019); p. 1917 – 1924; Zh. Strukt. Kim.; vol. 60; 12; (2019); p. 2002 – 2009,8;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1072-97-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1072-97-5 as follows.

Step-1: Synthesis of ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate To a stirred solution of 5-bromopyridin-2-amine (10.0 g, 56.0 mmol, 1.0 eq.) and ethyl 3-bromo-2-oxopropanoate (12.6 g, 64.0 mmol, 1.1 eq.) in Dioxane (200 mL) was added MgSO4 (20.0 g, 150.0 mmol, 3.0 eq.) at RT. The resulting mixture heated to 80 C. for 16 h. Following this, reaction mixture cooled to RT filtered the solid and under vacuum and filtrate concentrated to get crude. The crude purified by normal phase silica-gel column to get title compound (12 g, 79%). LCMS: 269.9 [M+1]+; 1H NMR (400 MHz, DMSO-d6) delta ppm 8.91 (d, J=1.32 Hz, 1H) 8.47 (s, 1H) 7.62 (d, J=9.65 Hz, 1H) 7.47 (dd, J=9.65, 1.75 Hz, 1H) 4.31 (q, J=7.16 Hz, 2H) 1.31 (t, J=7.02 Hz, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1072-97-5, its application will become more common.

Reference:
Patent; INTEGRAL BIOSCIENCES PRIVATE LIMITED; CHAKRAVARTY, Sarvajit; PENDHARKAR, Dhananjay; RAMACHANDRAN, Sreekanth A.; BATHULA, Chandramohan; SONI, Sanjeev; KUMAR, Vivek; SAEED, Uzma; DANODIA, Abhinandan Kumar; SHARMA, Ankesh; JADHAVAR, Pradeep S.; US2020/206233; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem