Category: 1072-97-5

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 1072-97-5, Name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2. In an article, author is Hosoya, Hiromu,once mentioned of 1072-97-5, Formula: C5H5BrN2.

4,4′-Bipyridyl-Catalyzed Reduction of Nitroarenes by Bis(neopentylglycolato)diboron

4,4′-Bipyridyl worked as an organocatalyst for the reduction of nitroarenes by bis(neopentylglycolato)diboron (13,nep2), followed by hydrolysis to give the corresponding anilines. This reduction proceeded under aerobic conditions without any prepurification of substrates and reagents. We found broad functional group tolerance and compatibility for 0- and N-protecting groups under the reaction conditions. The key in this catalytic system was the addition of 13,nep2 to 4,4′-bipyridyl to form N,N’-bis[(neopentylglycolato)boryl]-4,4′-bipyridinylidene reagent of nitroarenes. as a deoxygenating

Interested yet? Keep reading other articles of 1072-97-5, you can contact me at any time and look forward to more communication. Formula: C5H5BrN2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

1072-97-5, Name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, Quality Control of 5-Bromopyridin-2-amine, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Goker, Hakan, once mentioned the new application about 1072-97-5.

Regioselective N-alkylation of 2-(3,4-dimethoxyphenyl)imidazo[4,5-b] and [4,5-c]pyridine oxide derivatives : Synthesis and structure elucidation by NMR

Imidazopyridines can exist in several tautomeric forms such as benzimidazole or purine condensed systems. Regioselectivities were determined for N-alkylations of 2-(3,4-dimethoxyphenyl)- imidazopyridines and their 4 and 5-oxides (2-4, 13, 14) with n-butyl and 4-fluorobenzyl bromides under basic conditions (K2CO3 in DMF). It was observed that N-4 (5-8) and N-5 (15-17) regioisomers were mainly formed. Compounds 7 (N-4) and 7a (N-1) were separated from the mixtures of regioisomers in a 50 : 1 ratio. Their structural assignments were made with the use of two-dimensional H-1-H-1 NOE (nuclear overhauser effect spectroscopy [NOESY]) enhancements between the N-CH2 and protons on the C-4, 5, 6, and 7 positions of the pyridine moiety. To verify the NOESY data, synthesis of compounds 7a and 7b was achieved by the selective method. Complementary structural information was provided by 2D-HMBC spectra of the compounds. (C) 2019 Elsevier B.V. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1072-97-5 help many people in the next few years. Quality Control of 5-Bromopyridin-2-amine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Du, Pan, once mentioned the application of 1072-97-5, Name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, MDL number is MFCD00006323, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Recommanded Product: 1072-97-5.

Comparative DFT study of metal-free Lewis acid-catalyzed C-H and N-H silylation of (hetero)arenes: mechanistic studies and expansion of catalyst and substrate scope

Direct selective dehydrogenative silylation of thiophenes, pyridines, indoles and anilines to synthesize silyl-substituted aromatic compounds catalyzed by metal-free Lewis acids was achieved recently. However, there is still insufficient mechanistic data for these transformations. Using density functional theory calculations, we conducted a detailed investigation of the mechanism of the B(C6F5)(3)-catalyzed dehydrogenative silylation of N-methylindole, N,N-dimethylaniline and N-methylaniline. We successfully located the most favourable reaction pathways that can explain the experimental observations notably well. The most favourable pathway for B(C6F5)(3)-catalyzed C-H silylation of N-methylindole includes nucleophilic attack, proton abstraction and hydride migration. The C-H silylation of N,N-dimethylaniline follows a similar pathway to N-methylindole rather than that proposed by Hou’s group. Our mechanism successfully explains that the transformations of N-methylindoline to N-methylindole produce different products at different temperatures. For N-methylaniline bearing both N-H and para-phenyl C-H bonds, the N-H silylation reaction is more facile than the C-H silylation reaction. Our proposed mechanism of N-H silylation of N-methylaniline is different from that proposed by the groups of Paradies and Stephan. Lewis acids Al(C6F5)(3), Ga(C6F5)(3) and B(2,6-Cl2C6H3)(p-HC6F4)(2) can also catalyze the C-H silylation of N-methylindole like B(C6F5)(3), but the most favourable pathways are those promoted by N-methylindoline. Furthermore, we also found several other types of substrates that would undergo C-H or N-H silylation reactions under moderate conditions. These findings may facilitate the design of new catalysts for the dehydrogenative silylation of inactivated (hetero)arenes.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1072-97-5, Recommanded Product: 1072-97-5.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1072-97-5, name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 5-Bromopyridin-2-amine

Example 57b. 5-(l-Methyl-lH-pyrazol-4-yl)-pyridin-2-ylamineA mixture of 2-amino-5-bromopyridine (3.0 g, 17.3 mmol), l-methyl-4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2yl)-lH-pyrazole (5.4 g, 26.0 mmol) and potassium carbonate (3.6 g, 26.0 mmol) in dimethoxy ethane (60 mL) and water (10 mL) was degassed for 15 minutes using nitrogen. [l,l ‘-Bis(di-tert-butylphosphino)- ferrocene]palladium (II) dichloride (562 mg, 0.87 mmol) was added and the reaction mixture was heated in a sealed tube at 90 0C overnight. The mixture was cooled to room temperature and partitioned between ethyl acetate and aqueous sodium bicarbonate solution. The organic phase was separated and the aqueous layer was re-extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash column chromatography using a gradient of 2 to 5% methanol in dichloromethane. The desired fractions were collected and concentrated in vacuo, and the solid obtained was washed with diethyl ether to offord the title compound (2 g, 66%).1H NMR (400 MHz, CHLOROFORM-d) delta ppm 3.94 (s, 3 H) 4.39 (br. s., 2 H) 6.53 (d, J=8.21 Hz, 1 H) 7.50 (m, 2 H) 7.66 (s, 1 H) 8.21 (d, J=2.34 Hz, 1 H). ESMS m/z: [M+l]+ 175.1

With the rapid development of chemical substances, we look forward to future research findings about 1072-97-5.

Reference:
Patent; ASTRAZENECA AB; LO-ALFREDSSON, Yvonne; PAULSEN, Kim; RAKOS, Laszlo; ROTTICCI, Didier; WALDMAN, Magnus; WO2010/132015; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1072-97-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1072-97-5, name is 5-Bromopyridin-2-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, as common compound, the synthetic route is as follows.

A 1,2-dimethoxyethane solution (100 mL) of 2-amino-5-bromo-pyridine (5.19 g) and ethyl bromopyruvate (5.65 mL) was stirred for 2 hours at room temperature. The precipitated solid was filtered out, suspended in ethanol (180 mL) and refluxed for 2.5 hours. The reaction solution was concentrated under reduced pressure, and the residue was neutralized with saturated aqueous sodium hydrogencarbonate solution and extracted with chloroform. The extract was washed with saturated sodium chloride solution and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetate-hexane to obtain ethyl 6-bromoimidazo[1,2-a]pyridine-2-carboxylate (5.48 g) as colorless crystals. 1H-NMR (300MHz, CDCl3); delta 1.44 (3H, t, J=7.2Hz), 4.46 (2H, q, J=7.2Hz), 7.31 (1H, dd, J=1.8, 9.6Hz), 7.59 (1H, d, J=9.6Hz), 8.14 (1H, s), 8.29 (1H, d, J=1.8Hz)

Statistics shows that 1072-97-5 is playing an increasingly important role. we look forward to future research findings about 5-Bromopyridin-2-amine.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1849465; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1072-97-5, 5-Bromopyridin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1072-97-5, blongs to pyridine-derivatives compound. Product Details of 1072-97-5

Another literature procedure to perform aromatic substitutions with the methoxy anion was followed.12 The method uses salts of copper (I) and a small amount of ester to form a stabilized tetrahedral adduct which should act as a powerful methoxide donor (Figure 3). Unfortunately, due to the presence of the free amino group on the bromopyridine and the ethyl acetate as co-catalyst, the reaction product was just the acetamide of the substrate (eq 2).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-97-5, 5-Bromopyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; THE GOVERNMENT OF THE UNITED STATES, as represented by the secretary of HEALTH AND HUMAN SERVICES; WO2007/124345; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1072-97-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1072-97-5, name is 5-Bromopyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

In a 200 ml three-necked flask equipped with a stirrer and a thermometer, add 50 ml of a 48% hydrobromic acid solution, and dissolve 6.9 g (0.048 mol) of cuprous bromide in the hydrobromic acid solution.Slowly add 6 g (0.04 mol) of 2-amino-5-bromopyridine while maintaining the temperature in an ice-water bath at 0 C.Keep the temperature for 20 minutes, slowly add 10 ml of saturated sodium nitrite solution, and stir for 3.5 hours after the addition.The reaction was neutralized with 40% sodium hydroxide solution to pH = 7-8, and the product was distilled under reduced pressure with a yield of 64%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1072-97-5, 5-Bromopyridin-2-amine.

Reference:
Patent; Changzhou Chuanyou Environmental Protection Technology Co., Ltd.; Ni Jun; (5 pag.)CN110759858; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1072-97-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1072-97-5, name is 5-Bromopyridin-2-amine. A new synthetic method of this compound is introduced below.

(a) A mixture of concentrated sulphuric acid (35 ml) and nitric acid (35 ml) was added dropwise with stirring to a chilled (5 C.) solution of 2-amino-5-bromopyridine (50.3 g) in concentrated sulphuric acid (240 ml) maintaining the temperature of the reaction mixture at 5-6 C. throughout the addition. When the addition was complete, the reaction mixture was stirred for a further 1.0 hr. at 5-8 C. and then warmed to 30 C. and allowed to stand for ca 18 hr. Further concentrated nitric acid (35 ml) was added portionwise to the reaction mixture with stirring while maintaining the temperature at 30-40 C. A portion (50 ml) of the solution was poured into hot (ca 70 C.) water (100 ml) with rapid stirring and this mixture was heated to 120 C. Gas evolved. When the evolution of gas ceased further portions (75 ml) of the reaction mixture were added maintaining the temperature at 120 C. When the additions were completed, the solution obtained was poured into ice (1 kg) and chilled in a salt/ice bath. Fine orange crystals formed which were removed by filtration and recrystallized from dimethylformamide/water to give 2-hydroxy-3-nitro-5-bromopyridine (23.5 g) m.p. 240-243 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1072-97-5, 5-Bromopyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4532252; (1985); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem