Category: 107263-95-6

Kiselyov, Alexander S. published the artcileSynthesis of 2-substituted pyridines by the reaction of N-fluoropyridinium fluoride with trimethylsilyl derivatives, Product Details of C6H5F4NO3S, the publication is Journal of Organic Chemistry (1993), 58(16), 4476-8, database is CAplus.

A 1-pot preparation of 2-substituted pyridines in the reaction of N-fluoropyridinium fluoride generated in situ with C-, O- and N-(trimethylsilyl) compounds in the presence of a catalytic amount of Bu₄NF is described. Treatment of 1-fluoropyridinium fluoride with Et (trimethylsilyl)acetate gave Et 2-pyridineacetate (I) in 55% yield.

Journal of Organic Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Product Details of C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kiselyov, Alexander S. published the artcileA highly regioselective reaction of N-fluoropyridinium salts with stabilized sulfur, oxygen, and nitrogen nucleophiles: a convenient route to 2-substituted pyridines, HPLC of Formula: 107263-95-6, the publication is Journal of Heterocyclic Chemistry (1993), 30(5), 1361-4, database is CAplus.

2-Substituted pyridines I (R = phenoxy, phenylthio, imidazolyl, triazolyl, etc.) are efficiently obtained by the reactions of N-fluoropyridinium salts II (X = tetrafluoroborate, triflate) with anions derived from benzenethiols, phenols, azoles, cyanamide, and with azide anion. The results are consistent with a nucleophile addition at the position 2 of the N-fluoropyridinium cation as the major reaction pathway. The Reissert-Henze reaction of N-methoxypyridinium perchlorate to give I was unsuccessful.

Journal of Heterocyclic Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, HPLC of Formula: 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Roppe, Jeffrey published the artcileDiscovery of Novel Heteroarylazoles That Are Metabotropic Glutamate Subtype 5 Receptor Antagonists with Anxiolytic Activity, Product Details of C6H5F4NO3S, the publication is Journal of Medicinal Chemistry (2004), 47(19), 4645-4648, database is CAplus and MEDLINE.

The highly potent, selective, and brain-penetrant metabotropic glutamate subtype 5 (mGlu5) receptor antagonists 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile and 3-fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile are reported. Compound 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile is active in the rat fear-potentiated startle (FPS) model of anxiety with ED₅₀ = 5.4 mg/kg (po) when dosed acutely. In this model the anxiolytic effects of 3-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitrile rapidly tolerate on repeated dosing.

Journal of Medicinal Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Product Details of C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fujiwara, Tomoya published the artcileUseful procedures for fluorocyclization of tryptamine and tryptophol derivatives to 3a-fluoropyrrolo[2,3-b]indoles and 3a-fluorofuro[2,3-b]indoles, Safety of 1-Fluoropyridiniumtriflate, the publication is Journal of Fluorine Chemistry (2014), 7-13, database is CAplus.

Versatile procedures for fluorocyclization of various tryptamine and tryptophol derivatives to obtain the corresponding 3a-fluoropyrrolo[2.3-b]indoles and 3a-fluorofuro[2.3-b]indoles, resp. were developed employing N-fluoro-2,4,6-trimethylpyridinium triflate (FP-T300) or Selectfluor as the electrophilic fluorinating agent. The use of NaHCO₃ for fluorocyclization was effective in improving the yield of acid-labile fluoropyrrolo(furo)indoles. Our procedures are especially useful for the synthesis of fluoropyrrolo(furo)indoles bearing a free NH indole group.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Safety of 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ito, Satoru published the artcileDiscovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist, Synthetic Route of 107263-95-6, the publication is Bioorganic & Medicinal Chemistry (2008), 16(22), 9817-9829, database is CAplus and MEDLINE.

We describe here the discovery and the structure-activity relationship (SAR) of a series of 4-(1-Aryltriazol-4-yl)-tetrahydropyridines as novel mGluR1 antagonists. Our extensive chem. modification of the lead compound successfully led to fluoropyridine analogs with improved in vivo antagonistic activities. Among the evaluated compounds, a chem. stable urea analog showed oral antagonistic activity at dose ranges of 10-30 mg/kg in an animal model.

Bioorganic & Medicinal Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Synthetic Route of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ali, Hasrat published the artcileSynthesis of A-ring fluorinated derivatives of iodine-125-labeled (17α,20E/Z)-iodovinylestradiols: effect on receptor binding and receptor-mediated target tissue uptake, Synthetic Route of 107263-95-6, the publication is Journal of Medicinal Chemistry (1993), 36(21), 3061-72, database is CAplus and MEDLINE.

Title iodovinylestradiols (IVE₂) I, II, III and IV (X = H, Y = H, Me; X = OMe, Y = H) were prepared and in vitro and in vivo properties were their evaluated. Electrophilic substitution of the estrone derivatives and N-fluoropyridinium salt gave the 2- and 4-fluoro analogs which were subsequently converted to the 17α-ethynyl derivatives The tributylstannyl intermediates were obtained from the corresponding 17α-ethynyl analogs using azobisisobutyronitrile or triethylborane as catalyst. All 12 products were also prepared as their no-carrier-added [¹²⁵I]iodovinyl analogs via destannylation of the tributylstannyl precursors. Binding affinity for the estrogen receptor (ER) was in general higher for the 4-F derivatives as compared to the 2-F derivatives, while 20Z isomers of the same compounds showed somewhat higher ER binding affinity as compared to the 20E isomers. The combination of an A-ring fluoro and 7α- or 11β-substituent decreased ER binding affinity. Substitution of a fluoro atom at C-4 on either the 17α-ethynylestradiol or isomeric 17α-IVE₂ enhanced the affinity of the parent mol. for the ER. A-ring fluorination of all other analogs tested had no effect or depressed ER binding affinity. Varying incubation conditions showed substantial differences in ER binding kinetics between the 20E and 20Z isomers. Tissue distribution in immature female rats showed that the highest uterus uptake and uterus to blood/nontarget ratios in the IVE₂ series were obtained with the 4-F-(17α,20Z)IVE₂ isomer. The combination of A-ring fluoro and 7α- or 11β-substitution decreased uterus uptake but had little or no effect on uterus to blood/nontarget ratios. The highest uterus to blood ratios were observed for the 4-F-(17α,20E)11β-OMe-IVE₂ (75 at 6 h and 125 at 12 h pi) reflecting rapids blood clearance and in vivo stability, as confirmed by the low levels of thyroid radioactivity. The lack of correlation between ER binding affinities and uterus uptake,and/or uptake ratios, suggests that other factors, including nonspecific binding and metabolic processes, also are involved in the tissue localization process. The authors’ data suggest that 4-F substitution onto (17α,20Z)IVE₂ and (17α,20E)11β-OMe-IVE₂ enhances the potential of these compounds to function as SPECT imaging agents of ER-rich tissues.

Journal of Medicinal Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Synthetic Route of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xie, Long-Yong published the artcileSelectfluor-mediated regioselective nucleophilic functionalization of N-heterocycles under metal- and base-free conditions, Recommanded Product: 1-Fluoropyridiniumtriflate, the publication is Green Chemistry (2018), 20(3), 760-764, database is CAplus.

A practical and environmentally attractive methodol. for the direct diversification of N-heterocycles at ambient temperature under open-air conditions was developed. The obvious advantage of the process is that no toxic reagent, transition metal, base or other additive was employed, thus greatly reducing costs, facilitating post-reaction neutralization and purification and minimizing the environmental impact.

Green Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C4H12ClNO, Recommanded Product: 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gilicinski, Andrew G. published the artcileOn the relative power of electrophilic fluorinating reagents of the nitrogen-fluorine (N-F) class, Formula: C6H5F4NO3S, the publication is Journal of Fluorine Chemistry (1992), 59(1), 157-62, database is CAplus.

Electrochem. measurements have been employed as a measure of the relative chem. reactivity of a series of N-F class electrophilic fluorinating reagents. A correlation has been found between the potential for the first one-electron reduction of the reagents and their observed reactivity in synthetic fluorination reactions. Comparative electrochem. data in acetonitrile and DMF are reported.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Formula: C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zupan, Marko published the artcileReactions of the N-F class of fluorinating reagents with solvents, Computed Properties of 107263-95-6, the publication is Journal of Fluorine Chemistry (1996), 78(2), 137-140, database is CAplus.

The transformations of various reagents of the N-F type in water, acetonitrile, alcs. and aqueous solutions of alkali hydroxides were investigated. First-order kinetics for 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA) and 1-hydroxy-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (NFTh) transformations were established: F-TEDA is less stable in water at 60 °C than NFTh, while N-fluorobis(phenylsulfonyl)amine (NFS) is very stable. The addition of acetonitrile to an aqueous solution of F-TEDA enhanced the transformation (k = 1.3×10^-5 s^-1), while a reaction which was three-times faster was observed in water/methanol solution (k = 3.5×10^-5 s^-1 at 60 °C). The energy of activation for the transformation of F-TEDA in water was found to be 21.1 kcal mol^-1, 20.6 kcal mol^-1 in water/methanol solution and 13.8 kcal mol^-1 in a water/acetonitrile mixture

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C7H13BrSi, Computed Properties of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Adachi, Kenji published the artcileElectrophilic fluorination with N,N’-difluoro-2,2′-bipyridinium salt and elemental fluorine, Category: pyridine-derivatives, the publication is Journal of Fluorine Chemistry (2003), 120(2), 173-183, database is CAplus.

N,N’-Difluoro-2,2′-bipyridinium bis(tetrafluoroborate) (MEC-31) was shown to be a highly reactive electrophilic fluorinating agent with the highest effective fluorine content in its class. We have developed the perfect recycled fluorination system with MEC-31 for the lower-cost industrial fluorination and for an environment. MEC-31 can be completely recycled including the counter-anion. We found the fluorination of 2-naphthol in liquid CO₂ with MEC-31 in the presence of catalytic amount of NaOTf proceeded quant. without the generation of byproduct. In the fluorination of 1,3-dicarbonyl compounds with elemental fluorine, we found the introduction method of fluorine gas would be very important in order to make a reaction efficient. As fluorination goes on, the quantity of 1,3-dicarbonyl compounds of the starting material is reduced gradually, and therefore the quantity of fluorine must be reduced by the method to control the flow rate or the concentration of fluorine gas diluted with nitrogen, together the fluorination to proceed efficiently.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem