Category: 1075-62-3

Microwave-assisted synthesis of furo[3,2-c]-1,8-naphthyridines was written by Gullu, Mustafa;Yigit, Deniz. And the article was included in Synthetic Communications in 2011.Product Details of 1075-62-3 This article mentions the following:

Microwave-assisted ring-conversion reactions of some pyrido[1,2-a]pyrimidine derivatives to 1,8-naphthyridines were investigated. Novel furo[3,2-c]-1,8-naphthyridine compounds were synthesized in good yields under thermal reaction conditions. Both microwave and classical heating methods have been found to be satisfactory for the synthesis of new 1,8-naphthyridines. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Product Details of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2,6-Diaminopyridine and Acrylamide-Based Copolymers with Upper Critical Solution Temperature-type Behavior in Aqueous Solution was written by Asadujjaman, Asad;Ahmadi, Vahid;Michel Claude Franc, Antoine;Bertin, Annabelle. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2019.Application of 1075-62-3 This article mentions the following:

A novel copolymer based on supramol. motif 2,6-diaminopyridine and water-soluble acrylamide, poly[N-(6-acetamidopyridin-2-yl) acrylamide-co-acrylamide], was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization with various monomer compositions The thermoresponsive behavior of the copolymers was studied by turbidimetry and dynamic light scattering. The obtained copolymers showed an upper critical solution temperature (UCST)-type phase transition behavior in water and electrolyte solution The phase transition temperature was found to increase with decreasing amount of acrylamide in the copolymer and increasing concentration of the solution Furthermore, the phase transition temperature varied in aqueous solutions of electrolytes according to the nature and concentration of the electrolyte in accordance with the Hoffmeister series. A dramatic solvent isotope effect on the transition temperature was observed in this study, as the transition temperature was almost 10-12 鎺矯 higher in D₂O than in H₂O at the same concentration and acrylamide composition The size of the aggregates below the transition temperature was larger in D₂O compared to that in H₂O that can be explained by deuterium isotope effect. The thermoresponsive behavior of the copolymers was also investigated in different cell medium and found to be exhibited UCST-type phase transition behavior in different cell medium. Such behavior of the copolymers can be useful in many applications including biomedical, microfluidics, optical materials, and in drug delivery. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Application of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stimuli-responsive supramolecular materials: photo-tunable properties and molecular recognition behavior was written by Huang, Cheng-Wei;Wu, Pei-Wei;Su, Wei-Hung;Zhu, Chao-Yuan;Kuo, Shiao-Wei. And the article was included in Polymer Chemistry in 2016.Related Products of 1075-62-3 This article mentions the following:

A new homopolymer of polystyrene (PS) presenting pendant diaminopyridine (DAP) moieties was prepared using controlled free radical polymerization and a CuAAC click reaction. Through directional complementary multiple H bonding, this PVB-DAP polymer underwent complexation with a thymine-functionalized azobenzene (Azo-T). The resulting supramol. complex exhibited amorphous and chromophoric behavior without microphase separation This strategy allowed the fabrication of homogeneous stimuli-responsive thin films with photocontrollable behavior through photoinduced trans-cis isomerization. The PVB-DAP/Azo-T supramol. complex facilitated the dispersion of an azo-dye through noncovalent interactions; the resulting complex was used to fabricate a surface relief grating displaying an interference pattern. The recordability and rewritability of these supramol. complexes suggest that they are promising materials for optical applications and therefore advance the pathway for supramol. development. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Related Products of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Understanding the Effects of Preorganization, Rigidity, and Steric Interactions in Synthetic Barbiturate Receptors was written by McGrath, Jacqueline M.;Pluth, Michael D.. And the article was included in Journal of Organic Chemistry in 2014.Name: N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:

Synthetic barbiturate receptors have been utilized for many applications due to their high binding affinities for complementary guests. Although interest in this class of receptors spans from supramol. to materials chem., the effects of receptor steric bulk and preorganization on guest binding affinity has not been studied systematically. To investigate the roles that steric bulk and preorganization play in guest binding, we prepared a series of 12 deconstructed Hamilton receptors with varying degrees of steric bulk and preorganization. Both diethylbarbital and 3-methyl-7-propylxanthine were investigated as guests for the synthetic receptors. The stoichiometry of guest binding was investigated using Job plots for each host-guest pair, and ¹H NMR titrations were performed to measure the guest binding affinities. To complement the solution-state studies, DFT calculations at the B3LYP/6-31+G-(d,p) level of theory employing the IEF-PCM CHCl₃ solvation model were also performed. Calculated guest binding energies correlated well with the exptl. findings and provided addnl. insight into the factors influencing guest binding. Taken together, the results presented highlight the interplay between preorganization and steric interactions in establishing favorable interactions for self-assembled hydrogen-bonded systems. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Name: N-(6-Aminopyridin-2-yl)acetamide).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Name: N-(6-Aminopyridin-2-yl)acetamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and characterization of N-hydroxy-7-(3-substituted ureido)-4-(4-((4-(morpholinomethyl)phenyl)ethynyl)phenyl)-1,8-naphthyridine-2-carboxamides: a novel class of potential antibacterial, antifungal and anthelmintic agents was written by Prasad, V. Kamala;Sanjeeva, P.;Manjunath, G.;Rao, B. Subba;Ramana, P. Venkata. And the article was included in Heterocyclic Letters in 2022.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:

N-hydroxy-7-(3-substituted ureido)-4-(4-((4-(morpholinomethyl)phenyl)ethynyl) phenyl)-1,8-naphthyridine-2-carboxamides I [R = Et, i-Pr, Ph, etc.; R¹ = NHOH] were synthesized by treating Me 7-(3-substituted ureido)-4-(4-((4-(morpholinomethyl)phenyl)ethynyl) phenyl)-1,8-naphthyridine-2-carboxylate I [R¹ = OMe] with hydroxylamine in ethanol/THF. These newly synthesized 1,8-naphthyridine derivatives I were screened for their antibacterial, antifungal and anthelmintic activities against the resp. strains. The results showed that introduction of electron donating groups in the ureido moiety results in a significant decrease of antimicrobial activity and an increase in anthelmintic activity. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: N-(6-Aminopyridin-2-yl)acetamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Three-Point Hydrogen Bonding Assembly between a Conjugated PPV and a Functionalized Fullerene was written by Fang, Hongjuan;Wang, Shu;Xiao, Shengqiang;Yang, Junlin;Li, Yuliang;Shi, Zhiqiang;Li, Hongmei;Liu, Huibiao;Xiao, Shengxiong;Zhu, Daoben. And the article was included in Chemistry of Materials in 2003.Product Details of 1075-62-3 This article mentions the following:

A new self-assembly system between a PPV derivative and an organofullerene through a three-point hydrogen-bonding interaction was prepared The formation of hydrogen bonding was confirmed by ¹H NMR studies in CDCl₃. Fluorescence quenching experiments indicated that the fluorescence of uracil-containing polyphenylenevinylene derivative U-PPV was greatly quenched by 2,6-diacylamidopyridine-containing compound DAP-C₆₀ (K_SV = 5.8 鑴?10⁴ M^-1). In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Product Details of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bodipy-C₆₀ triple hydrogen bonding assemblies as heavy atom-free triplet photosensitizers: preparation and study of the singlet/triplet energy transfer was written by Guo, Song;Xu, Liang;Xu, Kejing;Zhao, Jianzhang;Kucukoz, Betul;Karatay, Ahmet;Yaglioglu, Halime Gul;Hayvali, Mustafa;Elmali, Ayhan. And the article was included in Chemical Science in 2015.Application of 1075-62-3 This article mentions the following:

Supramol. triplet photosensitizers based on hydrogen bonding-mediated mol. assemblies were prepared Three thymine-containing visible light-harvesting Bodipy derivatives (B-1, B-2 and B-3, which show absorption at 505 nm, 630 nm and 593 nm, resp.) were used as H-bonding modules, and 1,6-diaminopyridine-appended C₆₀ was used as the complementary hydrogen bonding module (C-1), in which the C₆₀ part acts as a spin converter for triplet formation. Visible light-harvesting antennae with methylated thymine were prepared as references (B-1-Me, B-2-Me and B-3-Me), which are unable to form strong H-bonds with C-1. Triple H-bonds are formed between each Bodipy antenna (B-1, B-2 and B-3) and the C₆₀ module (C-1). Singlet energy transfer from the Bodipy antenna to the C₆₀ module was confirmed by fluorescence quenching studies. The intersystem crossing of the latter produced the triplet excited state. The nanosecond transient absorption spectroscopy showed that the triplet state is either localized on the C₆₀ module (for assembly B-1·C-1), or on the styryl-Bodipy antenna (for assemblies B-2·C-1 and B-3·C-1). Intra-assembly forward-backward (ping-pong) singlet/triplet energy transfer was proposed. In contrast to the H-bonding assemblies, slow triplet energy transfer was observed for the non-hydrogen bonding mixtures As a proof of concept, these supramol. assemblies were used as triplet photosensitizers for triplet-triplet annihilation upconversion. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Application of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Application of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and pharmacological activity of some 3-amino-11H-indolo[3,2-c][1,8]naphthyridines was written by Da Settimo, A.;Primofiore, G.;Biagi, G.;Santerini, V.. And the article was included in Farmaco, Edizione Scientifica in 1976.SDS of cas: 1075-62-3 This article mentions the following:

The pyridines I (R = H, Ac) were cyclized and the naphthyridine II (X = O) treated with 4,2-RR1C6H3NHNH2 (R = H, F, Cl, Br, Me, R1 = H; R = H, R1 = Cl, Me, MeO) to give II (X = 4,2-RR1C6H3NHN), which were cyclized with HCl to give the indolonaphthyridines III. III were also prepared directly by treating II (X = O) with 4,2-RR1C6H3NHNH2 and HCl. 2,6-Diaminopyridine was treated with β-propiolactone to give I (R = HO2CCH2CH2) which was cyclized and the product dehydrogenated to give anthyridinedione IV. At 50 mg/kg III (R = F, R1 = H) reduced delayed hypersensitivity, but was toxic. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3SDS of cas: 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. SDS of cas: 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermoresponsive functional polymers based on 2,6-diaminopyridine motif with tunable UCST behaviour in water/alcohol mixtures was written by Asadujjaman, Asad;Ahmadi, Vahid;Yalcin, Meral;ten Brummelhuis, Niels;Bertin, Annabelle. And the article was included in Polymer Chemistry in 2017.Application of 1075-62-3 This article mentions the following:

2,6-Diaminopyridine based functional polymers poly(N-(6-aminopyridin-2-yl)acrylamide) (PNAPAAm) and poly(N-(6-acetamidopyridin-2-yl)acrylamide) (PNAcAPAAm) were synthesized via free radical polymerization and in addition PNAcAPAAm was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization for comparison. The obtained polymers displayed upper critical solution temperature (UCST)-type reversible thermoresponsiveness in water/alc. mixtures The UCST phase transition behavior of the obtained functional polymers was studied using temperature dependent turbidimetry, dynamic light scattering and ¹H-NMR measurements. The phase transition temperature of the polymers was tunable by varying either the concentration of the polymer solution, the nature of the alc. or the composition of the solvent mixture The cloud point temperature of PNAcAPAAm was found to decrease with increasing alc. content (MeOH, EtOH and iPrOH) in water/alc. mixtures Past a critical amount of EtOH or iso-PrOH in water, the cloud point temperature of PNAcAPAAm increased upon further addition of EtOH or iso-PrOH. Such functional polymers with tunable UCST behavior can be applicable in drug delivery, sensing, personal care and microfluidic applications. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Application of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Functional Supramolecular Polypeptides Involving π-π Stacking and Strong Hydrogen-Bonding Interactions: A Conformation Study toward Carbon Nanotubes (CNTs) Dispersion was written by Huang, Cheng-Wei;Mohamed, Mohamed Gamal;Zhu, Chao-Yuan;Kuo, Shiao-Wei. And the article was included in Macromolecules (Washington, DC, United States) in 2016.Recommanded Product: 1075-62-3 This article mentions the following:

New supramol. polypeptides have been prepared through simple ring-opening polymerization and “click” reactions. Postfunctionalization with diaminopyridine (DAP) moieties, capable of multiple hydrogen bonding, was an efficient approach toward forming α-helical-dominant polypeptides. The phys. crosslinked networks produced upon self-organization of the DAP units increased the glass transition temperature (T_g) of the polymers and sustained the secondary structures of the polypeptides. Addnl. thermal responsivity resulted from dynamic noncovalent bonding on the polymer side chains. Mol. recognition through heterocomplementary DAP···thymine (T) base pairs was revealed spectroscopically and then used to construct poly(γ-propargyl-L-glutamate)-g-N-(6-acetamidopyridin-2-yl)-11-undecanamide/thyminylpyrene (PPLG-DAP/Py-T) supramol. complexes. Transmission electron microscopy images revealed that this complex was an efficient dispersant of carbon nanotubes (CNTs). Indeed, it could disperse CNTs in both polar and nonpolar media, the direct result of combining two modes of secondary noncovalent bonding: multiple hydrogen bonding and π-π interactions. Furthermore, CNT composites fabricated with biocompatible polymers and high value of T_g should enable the development of bio-inspired carbon nanostructures and lead the way toward their biomedical applications. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Recommanded Product: 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem