Category: 108-48-5

Synthetic Route of 108-48-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.108-48-5, name is 2,6-Dimethylpyridine, molecular formula is C7H9N, molecular weight is 107.1531, as common compound, the synthetic route is as follows.

General procedure: A mixture of 2-methyl quinoline (1 mmol), aryl aldehyde (1 mmol), Ca (OTf)2 (5 mol%) andBu4NPF6 (2 mol%) were heated at 130 oC under neat condition for 4-5 h. After completion of the reaction (monitored by TLC), reaction mixture was brought to roomtemperature, diluted with dichloromethane, absorbed on silica gel and purified by column chromatography using petroleum ether/ethyl acetate to give the desired product.

Statistics shows that 108-48-5 is playing an increasingly important role. we look forward to future research findings about 2,6-Dimethylpyridine.

Reference:
Article; Yaragorla, Srinivasarao; Singh, Garima; Dada, Ravikrishna; Tetrahedron Letters; vol. 56; 43; (2015); p. 5924 – 5929;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 108-48-5, name is 2,6-Dimethylpyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H9N

To 20ml reactor followed by addition of a solvent [Bmim] BF4(2 ml), 2,6- lutidine (1 mmol), inter-cyano benzaldehyde (0.5 mol), the catalyst [Hnhm] HSO4(0.5 mmol), sealed reactor, 100 for 48 hours.After the reaction system was cooled with diethyl ether (2 ml) and extracted 6 times, the combined organic phases, the organic phase was dried over anhydrous magnesium sulfate, the organic phase by rotary evaporation to give the crude product.The crude product with petroleum ether: ethyl acetate = 3: 1 (v / v) as eluent and silica gel as the adsorption phase column chromatography, to obtain a solid productC2, Yield 80%. Since the catalyst and a solvent used for the reaction can be recycled after extraction system vacuum dried at 40 degrees Celsius for one hour, then sequentially added 2,6-lutidine (1 mmol), inter-cyano benzaldehyde (0.5 mol ), sealed heating 48 hours, the product was isolatedC2Yield 81%.And so, the catalyst cycle times can still use 8 to 80% yield of the productC2Yield not significantly reduced, indicating that the catalyst for this reaction can be recycled, greatly reducing the cost of the experiment, reducing waste emissions and environmental pollution. NMR data:1the H NMR (400 MHz, CDCl3, TMS) delta 7.60 -7.47 (m, 5H), 7.03 (d,J= 7.6 Hz, 1H), 6.86 (d,J=7.6Hz,1H),5.16(dd,J=3.2,8.8Hz,1H),2.96-3.08(m,2H),2.53(s,3H);13CNMR(400MHz,CDCl3TMS) delta158.8, 157.5, 149.7, 137.5, 132.2, 126.6, 121.7, 120.7, 119.0, 110.9, 72.7, 44.6, 24.3

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 108-48-5, 2,6-Dimethylpyridine.

Reference:
Patent; Qingdao Agricultural University; WANG, ZU-LI; ZHANG, XUE-YAN; DONG, DAO-QING; (8 pag.)CN104072406; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-48-5, name is 2,6-Dimethylpyridine, molecular formula is C7H9N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a 250 mL flask, 2,6-lutidine (5 mL, 43 mmol), NBS (N-bromosuccinimide) (7.65 g, 43 mmol) and CCl4 (75 mL) were sequentially added and the mixture was heated under reflux in an oil bath.To the above reflux solution was added AIBN (azobisisobutyronitrile) (0.125g / time, once every 1h, plus 7 times), the reaction was filtered off to remove the white succinimide precipitation,The filtrate was stripped to remove the solvent to give a tan oil, which was isolated as a pink oil (5.4 g, 68%) by column chromatography using CH2Cl2 as eluent.

The chemical industry reduces the impact on the environment during synthesis 108-48-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Northwest University; Zhang Ronglan; Yang Weixing; Su Yuanyuan; Zhao Jianshe; (16 pag.)CN107312024; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, Adding a certain compound to certain chemical reactions, such as: 108-48-5, 2,6-Dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-48-5, blongs to pyridine-derivatives compound.

General procedure: To a stirred solution of substituted indoline-2,3-diones (1.0 mmol) in dioxane (1 mL) was added lutidines/picolines (2.5 mmol) and Iodine (20 mol %). The resulting mixture was heated at reflux for 8 h. After completion of the reaction, poured EtOAc and then washed with an ice cold saturated aqueous Na2S2O3 solution (10 mL¡Á2). Organic layer washed sequentially with brine, ice water and dried over anhydrous MgSO4. Evaporation of the organic solvent afforded the crude products, which was purified by silica gel column chromatography using n-hexane/ethyl acetate (4:1-1:1) as eluent to give desired products.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-48-5, its application will become more common.

Reference:
Article; Vuppalapati, Srinivasu V.N.; Lee, Yong Rok; Tetrahedron; vol. 68; 39; (2012); p. 8286 – 8292;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-48-5, name is 2,6-Dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A 25 mL Schlenk tube equipped with a magneticstirring bar was charged with2,6-lutidine (0.75 mmol, 3equiv.), p-nitro-benzaldehyde(0.25 mmol), dioxane/water(1:1, 1ml) and [Hmim][H2PO4](1equiv.).The tube was sealed and heated at 100 for 24h. Aftercompletion of the reaction, the resulting solution was extracted with ether (3¡Á10 ml). The organic layer was dried with anhydrous Na2SO4,and concentrated under vacuum. The residue was chromatographed on a silica gelcolumn eluted with a mixture of petroleum ether and ethyl acetate (1:1) to givepure products (92%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 108-48-5, 2,6-Dimethylpyridine.

Reference:
Article; Zhang, Xue-Yan; Dong, Dao-Qing; Yue, Tao; Hao, Shuang-Hong; Wang, Zu-Li; Tetrahedron Letters; vol. 55; 40; (2014); p. 5462 – 5464;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-48-5, name is 2,6-Dimethylpyridine, molecular formula is C7H9N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 108-48-5

2,6-Lutidine (i) (5.1 g, 47.5 mmol, 1 equiv.) was dissolved in 300 mL of carbon tetrachloride, and the solution was degassed with argon. Azobisisobutyronitrile (AIBN, 0.8 g, 4.8 mmol, 0.1 equiv.) and N-bromosuccinimide (NBS, 9.3 g, 52.3 mmol, 1.1 equiv.) were added to the solution of i in small portions over a period of 3 h, while the reaction mixture was heated at 60 C (Scheme S1). The reaction mixture was irradiated with UV light throughout the reaction. After the addition was complete, the reaction mixture was refluxed for another 8 h. The reaction mixture was cooled to room temperature and filtered through Celite. The filtrate was concentrated in vacuo producing a brown residue, which was subject to SiO2 column chromatography using a gradient of ethyl acetate from 10 to 20% in hexanes. Pure fractions were combined, and solvent was removed in vacuo to afford a yellow oil. The product solidified in the freezer producing slightly pinkish white needles. Yield: 4.0 g, 46%. 1H NMR, 400 MHz (CDCl3, ppm): delta = 7.55 t (1H, Ar), 7.22 d (1H, Ar), 7.04 d (1 H, Ar), 4.49 s (2H, CH2), 2.53 s (3 H, CH3). 13C NMR, 75 MHz (CDCl3, ppm): delta = 158.38, 156.04, 137.16, 122.59, 120.39, 34.08, 24.36. ESI-MS (m/z): [M + H]+, calculated: 186.0, found: 186.0.

The chemical industry reduces the impact on the environment during synthesis 108-48-5, I believe this compound will play a more active role in future production and life.

Reference:
Conference Paper; Dorazio, Sarina J.; Tsitovich, Pavel B.; Gardina, Stephanie A.; Morrow, Janet R.; Journal of Inorganic Biochemistry; vol. 117; (2012); p. 212 – 219;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108-48-5, name is 2,6-Dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 2-methyl quinoline (1 mmol), aryl aldehyde (1 mmol), Ca (OTf)2 (5 mol%) andBu4NPF6 (2 mol%) were heated at 130 oC under neat condition for 4-5 h. After completion of the reaction (monitored by TLC), reaction mixture was brought to roomtemperature, diluted with dichloromethane, absorbed on silica gel and purified by column chromatography using petroleum ether/ethyl acetate to give the desired product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-48-5, 2,6-Dimethylpyridine.

Reference:
Article; Yaragorla, Srinivasarao; Singh, Garima; Dada, Ravikrishna; Tetrahedron Letters; vol. 56; 43; (2015); p. 5924 – 5929;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

108-48-5, Adding a certain compound to certain chemical reactions, such as: 108-48-5, 2,6-Dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-48-5, blongs to pyridine-derivatives compound.

In a separate flask, a mixture of 2,6-bis(methyl)pyridine(3.5 mL, 30 mmol) and N-bromosuccinimide (NBS) (10.70 g, 60.12 mmol) in CCl4 (400mL) was refluxed in the presence of azodiisobutyronitrile (AIBN) (0.15 g, 0.9 mmol) for 6 h under theirritation of 200 W lamp. After being cooled to room temperature, the mixture was filtered and the filtrate was concentrated in vacuo. Purification was achieved by flashed column chromatography using ethyl acetate / petroleum ether = 1 / 10 as eluent. The second band solution was collected, combined and evaporated in vacuo to afford the product as a white crystal (4.5 g, 37%). 1H NMR (delta, ppm,400 M, CDCl3): 4.55(s, CH2), 7.38 (d, Py, J= 7.76 Hz), 7.72 (q, Py).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-48-5, its application will become more common.

Reference:
Article; You, Xiuli; Wei, Zhenhong; Inorganica Chimica Acta; vol. 423; PA; (2014); p. 332 – 339;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A common compound: 108-48-5, name is 2,6-Dimethylpyridine,molecular formula is C7H9N, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 108-48-5

Reaction of 2, 6-lutidine and formaldehyde was carried out over Na-ZSM-5 (SiO2/ Al2O3 = 30) at 300C with 0.5 H W. H. S. V. The catalyst was 4 G with 18-30 mesh size and feed rate of 2 ml. H 1. The molar ratio of 2, 6-lutidine to formaldehyde 1: 4. The liquid product selectivities were 30.4 and 69. 6 % for 2, 6-DVP and 2DVP respectively, at 53.3 wt% conversion of 2,6-lutidine.

With the rapid development of chemical substances, we look forward to future research findings about 108-48-5.

Reference:
Patent; COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; WO2004/87664; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem