Category: 108-96-3

Adding a certain compound to certain chemical reactions, such as: 108-96-3, Pyridin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 108-96-3, blongs to pyridine-derivatives compound. Product Details of 108-96-3

Example 45; 4-[[2-(4-Pyridinyloxy)ethyl](2,2,2-trifluoroethyl)amino]-2- (trifluoromethyl)benzonitrile; Synthesized as described in Example 1C from 4-[(2-hydroxyethyl)(2,2,2- trifluoroethyl)amino]-2-(trifluoromethyl)benzonitrile and 4-pyridone, using dry DME as reaction solvent: 1H NMR (400 MHz, CDCI3) delta 8.45 (dd, J = 5.0, 1.3 Hz, 2H), 7.68 (d, J = 8.8 Hz, 1 H), 7.18 (d, J = 2.5 Hz, 1 H), 7.01 (dd, J = 8.7, 2.6 Hz, 1 H), 6.77 (dd, J = 4.9, 1.3 Hz, 2H), 4.27 (t, J = 5.2 Hz, 2H), 4.19 (q, J = 8.5 Hz, 2H), 4.04 (t, J = 5.3 Hz, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,108-96-3, Pyridin-4(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2006/44707; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 108-96-3, Adding some certain compound to certain chemical reactions, such as: 108-96-3, name is Pyridin-4(1H)-one,molecular formula is C5H5NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108-96-3.

I Oa. 3,5-Diiodo-pyridin-4-ol Into a 3 L three necked round bottom flask I ,4-dihydropyridin-4-one (50.0 g, 0.50 mol) and N-iodosuccinimide (232 g, 1.00 mmol) were suspended inacetonitrile (1 L). The reaction mixture was refluxed for 3h. The mixture was cooled down with an ice bath and then filtered and washed with acetonitrile (150 mL). The light yellow solid was dried at 60C under reduced pressure for 15 hr to obtain 165 g (95 %) of the title compound as a light yellow solid. LC/MS (Method B): Rt 1.34 mm, (M+H) 348.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 108-96-3, Pyridin-4(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LIMITED; SCHIEMANN, Kai; STIEBER, Frank; CALDERINI, Michel; BLAGG, Julian; MALLINGER, Aurelie; WAALBOER, Dennis; RINK, Christian; CRUMPLER, Simon Ross; (127 pag.)WO2015/144290; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem