Category: 1086381-28-3

Adding a certain compound to certain chemical reactions, such as: 1086381-28-3, 4-Bromo-2-cyclopropylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1086381-28-3, blongs to pyridine-derivatives compound. Quality Control of 4-Bromo-2-cyclopropylpyridine

Example 53i 1-(2-Bromopyridin-4-yl)-1-(2-cyclopropylpyridin-4-yl)-4-fluoro-1H-isoindol-3-amine Under an atmosphere of argon, tert-butyllithium (1.7 M in pentane) (0.576 mL, 0.98 mmol) was added dropwise to anhydrous tetrahydrofuran (4.00 mL) at -100 C. 4-Bromo-2-cyclopropylpyridine (0.097 g, 0.49 mmol) in anhydrous THF (2.00 mL) was added dropwise to the mixture. The solution was stirred for 2 minutes before dropwise addition of a solution of N-((2-bromopyridin-4-yl)(2-cyano-3-fluorophenyl)methylene)-2-methylpropane-2-sulfinamide (0.200 g, 0.49 mmol) in anhydrous THF (2.00 mL). The reaction was stirred at -100 C. for 20 minutes, then the temperature was raised to -78 C. over a period of 10 minutes. The reaction was stirred at -78 C. for another 60 minutes. MeOH (2.0 mL) was added dropwise at -78 C. followed by hydrogen chloride (1.25 M in methanol) (1.176 mL, 1.47 mmol). The cooling bath was removed and the reaction was left to stir at ambient temperature for 60 minutes. The solvents were evaporated and the residue was partitioned between EtOAc and saturated aqueous NaHCO3. The aqueous layer was extracted with EtOAc (*2), the organics were combined, dried (Na2SO4), filtered and evaporated. Purification by silica chromatography using 0 to 5% (3.5 M ammonia in methanol) in dichloromethane gave the title compound (0.094 g, 45%). 1H NMR (500 MHz, DMSO-d6) delta ppm 8.30 (dd, 2H) 7.72 (d, 1H) 7.58 (td, 1H) 7.42-7.47 (m, 1H) 7.37 (dd, 1H) 7.32 (dd, 1H) 7.18-7.22 (m, 1H) 7.00 (dd, 1H) 6.80 (br. s., 2H) 1.99-2.07 (m, 1H) 0.81-0.95 (m, 4H); MS (ES+) m/z 423, 425 [M+1]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1086381-28-3, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; US2010/125082; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1086381-28-3, 4-Bromo-2-cyclopropylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

To a stirred solution of aryl bromide (4.42 mmol) in anhydrous DMF (16 mL) was added ethyl acrylate (5.75 mmol), Pd(OAc)2 (0.44 mmol), DABCO (8.84 mmol) and potassium carbonate (8.84 mmol). The solution was degassed under nitrogen for 15 min before heating to 125C for 17 h. The mixture was cooled, diluted with H2O (30 mL) and extracted into DCM (2 x 30 mL). The organic layers were washed with H2O (3 x 50 mL) and brine (2 x 50 mL), passed through a phase separator and concentrated. Following method D from 4-bromo-2-(cyclopropyl)pyridine (1 .00 g, 5.05 mmol). Purification by flash silica column chromatography (gradient elution /’-hex to 10% EtOAc in /-hex) gave the title compound as a white solid (530 mg, 48%). LCMS (ES+) 218 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1086381-28-3, 4-Bromo-2-cyclopropylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; CHDI FOUNDATION, INC.; LUCKHURST, Christopher A.; HAUGHAN, Alan F.; BRECCIA, Perla; STOTT, Andrew J.; BURLI, Roland W.; HUGHES, Samantha J.; MUNOZ-SANJUAN, Ignacio; DOMINGUEZ, Celia; MANGETTE, John E.; WO2012/103008; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1086381-28-3, 4-Bromo-2-cyclopropylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1086381-28-3, blongs to pyridine-derivatives compound. Formula: C8H8BrN

[0609] Step 1: 3-chloro-4-(2′-[3,4′-bipyridin]-5-yl)aniline. A stirred solution of 4-bromo-2-cyclopropylpyridine (350 mg, 1.76 mmol), (5-(4-amino-2-chlorophenyl)pyridin-3-yl)boronic acid (526 mg,2.12 mmol) and potassium carbonate (730 mg, 5.30 mmol) in 1,4-dioxane (5.6 mL) and water (1.4 mL) was purged with nitrogen gas for 15 minutes. After adding palladium Pd(PPli3)4 (2′-chloro-4-(2′-cyclopropyl-[3,4′-bipyridin]-5-yl)aniline (0.500 g, 88%) as a gum.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1086381-28-3, its application will become more common.

Reference:
Patent; CAPULUS THERAPEUTICS, LLC; GREEN, Michael John; HART, Barry Patrick; (341 pag.)WO2019/148125; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem