Category: 109-09-1

Application of 109-09-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-09-1, name is 2-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, as common compound, the synthetic route is as follows.

Synthesis of pyridin-2-yl-hydrazine (2): To a stirredsolution of 1 (20 g, 0.176 mol, 1 equiv) in hydrazine hydrate (200 mL, 10 vol) was stirred at 100 C for 48 h. When TLC (8:2 EtOAc and methanol) showed complete consumption of the starting material, the reaction mixture was diluted with water (200 mL) and extracted with ethyl acetate (5 × 500 mL), dried over Na2SO4 evaporated to dryness under reduced pressure to afford 2 (15.0 g, 78 %) as a red oil; 1H NMR (300 MHz,CDCl3): delta 8.14 (1H, d, J = 3 Hz, Ar-H), 7.51-7.45 (1H, m, Ar-H), 6.71-6.66 (2H, m, Ar-H), 5.78 (1H, brs, -NH), 3.81 (2H,brs, -NH2); LCMS calculated for C5H7N3: 109.13; Found 110.1,[M+H]+

The chemical industry reduces the impact on the environment during synthesis 109-09-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Gandikota, N. Murthy; Bolla, R. Sekhar; Viswanath, I. V. Kasi; Bethi, Sridharreddy; Asian Journal of Chemistry; vol. 29; 9; (2017); p. 1920 – 1924;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 109-09-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-09-1, name is 2-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, as common compound, the synthetic route is as follows.

General procedure: 20 mL scintillation vial was charged with a solution of MnCl2THF1.6 (3 mol%, 3 mg, 0.012mmol) in 3 mL THF in a glove box. The corresponding electrophile (0.41 mmol, 1 equiv.) andinternal standard, mesitylene (0.41 mmol, 1equiv.), were added. After five minutes of stirring atroom temperature, the Grignard solution (1.2- 2.6 equiv.) was added dropwise and the reactionwas stirred at room temperature. The reaction mixture was removed from the glovebox andquenched with a saturated K2CO3 solution (3 mL) and EtOAc (3 mL). The organic layer wasextracted with EtOAc (3 x 3mL), and dried over MgSO4. The solution was then filtered andconcentrated. The crude product was purified via a silica plug.

The chemical industry reduces the impact on the environment during synthesis 109-09-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Petel, Brittney E.; Purak, Merjema; Matson, Ellen M.; Synlett; vol. 29; 13; (2018); p. 1700 – 1706;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109-09-1, name is 2-Chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C5H4ClN

General procedure: To a stirred suspension of appropriate aryl halide(2.0 mmol) and phenol (2.0 mmol) in 6 ml water, Ni-alumina (0.125g, 6 mol % ofnickel metal) was added followed by K2CO3 (0.28 g, 2mmol) and SDS (0.04 g, 8 mol%). The reaction mixture was stirred for therequired period of time at 80C till the reaction was complete (monitored withTLC). Then the reaction mixture was cooled to room temperature, ethyl acetate(20 mL) was added to dissolve the product and the catalyst was separated simplyby filtration. The residue (recovered catalyst) was thoroughly washed withEtOAc (4×5 mL) followed by water (2×10 mL). The aqueous reaction mixture was repeatedly extracted with ethyl acetate (3×5 mL). The combined organic extractswere washed with water (3× 10 mL) and dried over anhydrous Na2SO4.The crude product was obtained by removal of the solvent under reduced pressure which was furtherpurified by filtration chromatography on a short column of silica gel using1-4% ethyl acetate-hexane as eluent.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-09-1, 2-Chloropyridine.

Reference:
Article; Ghatak, Avishek; Khan, Sagar; Roy, Rimi; Bhar, Sanjay; Tetrahedron Letters; vol. 55; 51; (2014); p. 7082 – 7088;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 109-09-1, name is 2-Chloropyridine. A new synthetic method of this compound is introduced below., name: 2-Chloropyridine

General procedure: 2-Chloropyridines were dissolved in EtOH and hydrazine hydrate added. The solution was heated in a thick walled sealed vial for 72h at 55 C, concentrated under a stream of nitrogen and purified by silica gel chromatography, (hexanes/ethylacetate).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 109-09-1, 2-Chloropyridine.

Reference:
Article; Finlay, Heather J.; Jiang, Ji; Caringal, Yolanda; Kover, Alexander; Conder, Mary Lee; Xing, Dezhi; Levesque, Paul; Harper, Timothy; Hsueh, Mei Mann; Atwal, Karnail; Blanar, Michael; Wexler, Ruth; Lloyd, John; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1743 – 1747;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 109-09-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-09-1, name is 2-Chloropyridine, molecular formula is C5H4ClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Asolution of 2-chloropyridine ( XI) (9.39 mL, 0.1 mol) in, anhydrous THF (50 mL) was added slowly to a solution of LDA (2.0 M solution in THF/ hexane/ethylbenzene, 50 mL, 0.1 mol) in THF (200 mL) stirred at -78 C. under nitrogen. The stirring was continued at -78 C. for an additional 3 h before adding acetaldehyde (6.17 mL, 0.110 mol). The solution was stirred at -78 C. for another 2 h before allowing the temperature to rise to -40 C. A solution of water (4 mL) in THF (40 mL) was added slowly to the solution. When the temperature reached -10 C., additional water (200 mL) was added to the solution. The solution was extracted with ethyl ether (3×100 mL). The combined organic phase was dried over MgSO4, filtered and evaporated under reduced pressure to get a brown viscous residue. The crude product was purified on a flash silica gel column (1:1 DCM:hexane?100% DCM) to produce 1-(2-chloropyridin-3-yl)ethanol (XII) as a brown viscous oil (6 g, 38.1 mmol, 38% yield). 1H NMR (CDCl3) delta ppm 1.52 (d, J=6.41 Hz, 3H), 2.51 (brs, 1H), 5.24 (m, 1H), 7.28 (m, 1H), 7.97 (dd, J=7.72 Hz, J=1.70 Hz, 1H), 8.27 (dd, J=7.72 Hz, J=1.79 Hz, 1H).

According to the analysis of related databases, 109-09-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Samumed, LLC; Hood, John; Kumar KC, Sunil; Wallace, David Mark; US2013/296302; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 109-09-1 ,Some common heterocyclic compound, 109-09-1, molecular formula is C5H4ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 2-chloro-5-methyl-benzimidazole (10.2 g, 61.2 mmol) and hydrazine monohydrate (59 mL, 1.22 mol) was stirred at 100 C overnight. After being cooled to ambient temperature, to the reaction mixture was added to water (60 mL). After stirring under ice cooling, the resulting precipitates were collected by filtration. The precipitates were washed with water 3 times, and then dried in vacuo to give 2-hydrazino-5-methyl-benzimidazole (8.4 g, 84.6%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,109-09-1, its application will become more common.

Reference:
Article; Nakao, Syuhei; Mabuchi, Miyuki; Shimizu, Tadashi; Itoh, Yoshihiro; Takeuchi, Yuko; Ueda, Masahiro; Mizuno, Hiroaki; Shigi, Naoko; Ohshio, Ikumi; Jinguji, Kentaro; Ueda, Yuko; Yamamoto, Masatatsu; Furukawa, Tatsuhiko; Aoki, Shunji; Tsujikawa, Kazutake; Tanaka, Akito; Bioorganic and Medicinal Chemistry Letters; vol. 24; 4; (2014); p. 1071 – 1074;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 109-09-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-09-1, name is 2-Chloropyridine, molecular formula is C5H4ClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 21 was repeated in the absence of zinc chloride. A yield in moles of 4-(2′-pyridyl)benzaldehyde of 26% was obtained relative to the 2-chloropyridine added, palladium turnover of 520.

According to the analysis of related databases, 109-09-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Euticals Prime European Therapeutical SpA; US6765097; (2004); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 109-09-1, name is 2-Chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 109-09-1

General procedure: In an oven dried glass tube containing a mixture of pyridine 1a (100 mg, 1.26 mmol), and potassium persulphate (683 mg, 2.53 mmol), formamide 2a (2 ml) was added and the reaction mixture was heated at 70 C. Upon the completion of the reaction (monitored by TLC), saturated sodium bicarbonate solution (5 mL) was added and the crude product was extracted in ethyl acetate (3 X 5 mL). The crude product was purified by column chromatography to furnish compound 3aa as a white crystalline solid (122 mg, 79% yield)

With the rapid development of chemical substances, we look forward to future research findings about 109-09-1.

Reference:
Article; Mete, Trimbak B.; Singh, Ankit; Bhat, Ramakrishna G.; Tetrahedron Letters; vol. 58; 50; (2017); p. 4709 – 4712;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem