Sources of common compounds: 5-Chloro-2-methyl-3-pyridinecarboxylic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1092286-30-0, 5-Chloro-2-methyl-3-pyridinecarboxylic acid, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1092286-30-0, 5-Chloro-2-methyl-3-pyridinecarboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1092286-30-0, blongs to pyridine-derivatives compound. Recommanded Product: 1092286-30-0

5-Chloro-2-methylnicotinoyl chloride5-Chloro-2-methyl-nicotinic acid (4.15 g, 24.2 mmol) was placed in a flask with DCM (100 ml) and oxalyl chloride (3.68 g, 29 mmol). DMF (200muIota) was added and the reaction mixture was stirred at RT for 1 hour (gas evolution). The mixture was filtered and the solvent was removed in vacuo to afford the title product which was used without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1092286-30-0, 5-Chloro-2-methyl-3-pyridinecarboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; BEATTIE, David; BRUCE, Ian; COLSON, Anny-Odile; CULSHAW, Andrew James; SHARP, Thomas; WO2011/95450; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Brief introduction of 1092286-30-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1092286-30-0, its application will become more common.

Synthetic Route of 1092286-30-0 ,Some common heterocyclic compound, 1092286-30-0, molecular formula is C7H6ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-Chloro-2-methyl-nicotinic acid (4.15 g, 24.2 mmol) is placed in a flask with DCM (100 mL) and oxalyl chloride (3.68 g, 29 mmol). DMF (200 muL) is added and the reaction mixture is stirred at r.t. for 1 hour (gas evolution). The mixture is filtered and the solvent is removed in vacuo to afford the title product which is used in the next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1092286-30-0, its application will become more common.

Reference:
Patent; Beattie, David; Colson, Anny-Odile; Culshaw, Andrew James; Sharp, Lisa; Stanley, Emily; Sviridenko, Lilya; US2010/35898; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1092286-30-0

Statistics shows that 1092286-30-0 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-2-methyl-3-pyridinecarboxylic acid.

Electric Literature of 1092286-30-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1092286-30-0, name is 5-Chloro-2-methyl-3-pyridinecarboxylic acid, molecular formula is C7H6ClNO2, molecular weight is 171.58, as common compound, the synthetic route is as follows.

Example 3.1 and 3.2Trans-5-Chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-1 -ylmethyl)- cyclohexyl]-2-methyl-nicotinamide and Trans-5-Chloro-N-[4-(5,6-dihydro-4H- cyclopentapyrazol-2-ylmethyl)-cyclohexyl] -2-methyl-nicotlnamideTrans-4-(5,6-dihydro-4H-cyclopentapyrazof-1-ylrriethyl)-cydohexylamine(intermediate H) (118 mg, 0.461 mmol) was suspended in DMF (2 ml) and treated with 5-chloro-2-methyl-nicotinic acid (96 mg, 0.461 mmol) and HATU (210 mg, 0.554 mmol) . DIPEA (0.321 ml, 1.845 mmol) was added and the reaction mixture was stirred at RT for 1 hour. The mixture was partitioned between DC and water and the organic phase was separated and washed with water, brine, dried (MgS04) and the solvent was removed in vacuo. The crude product was purified by chromatography on basic Alumina, eluting with a iso-hexane/EtOAc to afford a -1: 1 mixture of regiosisomers.LCMS Rt = 2.15 min; [M+H 373. Method LowpH_v002. The mixture was separated using by SFC using conditions described in the ‘General Conditions’ section.Ex. 3.1 : Trans-5-Chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-1-ylmethyl)- cyclohexyl]-2-methyl-nicotinamide:1 H N R (500MHz, DMSO) delta 8.52 (1 H, d), 8.40 (1 H, d), 7.78 (1 H, d), 7.06 (1H, s), 3.80 (2H,d) 3.66 (1H, m), 2.66 (2H, m), 2.51 (2H, m), 2.47 (3H, s), 1.91 (2H, m), 1.73 (1H, m), 1.59 (2H, m), 1.21 (2H, m), 1.08 (2H, m).Ex. 3.2: Trans-5-Chloro-N-[4-(5,6-dihydro-4H-cyclopentapyrazol-2-ylmethyl)- cyclohexyl] -2-methyl-nicotinamide:1 H NMR {500MHz, DMSO) delta 8.52 (1 H, d), 8.40 (1 H, d), 7.78 (1 H, d), 7.27 (1 H, s), 3.83 (2H,d) 3.65 (1H, m), 2.53 (2H, m), 2.48 (3H, s), 2.30 (2H, m), 1.89 (2H, m), 1.71 (1H, m), 1.58 (2H, m), 1.20 (2H, m), 1.05 (2H, m).

Statistics shows that 1092286-30-0 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-2-methyl-3-pyridinecarboxylic acid.

Reference:
Patent; NOVARTIS AG; BEATTIE, David; BRUCE, Ian; COLSON, Anny-Odile; CULSHAW, Andrew James; SHARP, Thomas; WO2011/95450; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 5-Chloro-2-methyl-3-pyridinecarboxylic acid

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1092286-30-0, its application will become more common.

Electric Literature of 1092286-30-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1092286-30-0 as follows.

A mixture of 4-(6-(4-amino-4-methylpiperidin-l-yl)pyridin-3-yl)-6-(2-hydroxy-2- methylpropoxy)pyrazolo[l,5-a]pyridine-3-carbonitrile dihydrochloride (Intermediate P48;53 mg, 0.107 mmol), HATU (44.9mg, 0.118 mmol), and 5-Chloro-2-methyl-3- pyridinecarboxylic acid (36.9 mg, 0.107 mmol) in DMSO (1.28 mL, 0.1 M) was treated with DIEA (0.09 mL, 0.54 mmol) and then stirred for 18 h at ambient temperature. The reaction mixture was diluted with EtOAc and washed with water. The organic extracts were washed with brine, then dried over anhydrous Na2S04(S), filtered and concentrated in vacuo. The residue was suspended in 60:40 ACN:water containing 2% TFA. The solution was purified directly by C18 reverse phase chromatography (5-95% ACN in water with 0.1% TFA as the gradient eluent) to afford the title compound as the TFA salt. The TFA salt was treated with saturated NaHCCb(aq) and extracted with DCM. The combined organic extracts were washed with brine, then dried over anhydrous Na2S04(S), filtered and concentrated in vacuo to afford the title compound (26.1 mg, 42% yield). MS (apci) m/z = 574.2 (M+H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1092286-30-0, its application will become more common.

Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some tips on 5-Chloro-2-methyl-3-pyridinecarboxylic acid

According to the analysis of related databases, 1092286-30-0, the application of this compound in the production field has become more and more popular.

Related Products of 1092286-30-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1092286-30-0, name is 5-Chloro-2-methyl-3-pyridinecarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Step 1 : 5-Chloro-2-methylnicotinoyl chloride5-Chloro-2-methyl-nicotinic acid (4.15 g, 24.2 mmol) was placed in a flask with DCM (100 ml) and oxalyl chloride (3.68 g, 29 mmol). DMF (200 muIota) was added and the reaction mixture was stirred at RT for 1 hour (gas evolution). The mixture was filtered and the solvent was removed in vacuo to afford the title product which was used in the next step without further purification.

According to the analysis of related databases, 1092286-30-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ATKINSON Benjamin; BEATTIE David; CULSHAW Andrew James; DEVEREUX Nicholas James; MCKENNA Jeffrey; DALE James; WO2011/92293; A1; (2011);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem