Category: 109613-90-3

Adding a certain compound to certain chemical reactions, such as: 109613-90-3, 2-Chloro-3-fluoro-4-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Chloro-3-fluoro-4-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2-Chloro-3-fluoro-4-nitropyridine

A solution of 2-aminoethanol (0.67 mL; 11 mmol) cooled to 0 C was treated with 2-chloro-3-fluoro-4- nitropyridine (2.00 g; 11 mmol) and stirred for 0.5 h. A solid was formed, which was then purified by column chromatography (silica gel; PE : EA; 1 :1 to 0:1 ; v/v) to afford 2-[(2-chloro-4-nitro-3- pyridyl)amino]ethanol (1.68 g) as an orange solid. ‘H-NMR (400 MHz, CDC13) delta ppm: 7.85 (d, J= 5.6 Hz, 1H), 7.68 (d, J= 5.6 Hz, 1H), 3.89 – 3.85 (m, 2H), 3.56 – 3.52 (m, 2H).

The synthetic route of 109613-90-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASILEA PHARMACEUTICA INTERNATIONAL AG; RICHALET, Florian; WEILER, Sven; EL SHEMERLY, Mahmoud; LANE, Heidi; (131 pag.)WO2019/72978; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 109613-90-3, 2-Chloro-3-fluoro-4-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Chloro-3-fluoro-4-nitropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2-Chloro-3-fluoro-4-nitropyridine

A solution of 2-aminoethanol (0.67 mL; 11 mmol) cooled to 0 C was treated with 2-chloro-3-fluoro-4- nitropyridine (2.00 g; 11 mmol) and stirred for 0.5 h. A solid was formed, which was then purified by column chromatography (silica gel; PE : EA; 1 :1 to 0:1 ; v/v) to afford 2-[(2-chloro-4-nitro-3- pyridyl)amino]ethanol (1.68 g) as an orange solid. ‘H-NMR (400 MHz, CDC13) delta ppm: 7.85 (d, J= 5.6 Hz, 1H), 7.68 (d, J= 5.6 Hz, 1H), 3.89 – 3.85 (m, 2H), 3.56 – 3.52 (m, 2H).

The synthetic route of 109613-90-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASILEA PHARMACEUTICA INTERNATIONAL AG; RICHALET, Florian; WEILER, Sven; EL SHEMERLY, Mahmoud; LANE, Heidi; (131 pag.)WO2019/72978; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem