Category: 1104455-41-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1104455-41-5, name is Methyl 4-chloro-5-methylpicolinate. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

To a stirred solution of methyl 4-chloro-5-methylpicolinate (220 mg, 1.2 mmol) in DMSO (10 mL) purged and maintained under an inert atmosphere of N2, was added Cu504.5H20 (15 mg, 0.06 mmol.), KOH (336 mg, 6 mmol) and a solution of 1,2-ethanedithiol (226 mg, 2.4 mmol) in water (1 mL). The resulting solution was heated to 90 oC overnight, cooled to 25 oC and concentrated to afford the crude title compound. MS (ES) m/z 170 (M+H).

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Reference:
Patent; CORVUS PHARMACEUTICALS, INC.; HUDSON, Ryan; BEAUSOLEIL, Anne-Marie; (616 pag.)WO2018/89261; (2018); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1104455-41-5, name is Methyl 4-chloro-5-methylpicolinate. A new synthetic method of this compound is introduced below., Product Details of 1104455-41-5

A mixture of methyl 4-chloro-5-methylpyridine-2-carboxylate (200 mg, 1.08 mmol), 1- cyclopropyl-4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrazole (302.7 mg, 1.29 mmol), Pd(dppf)Cl2-CH2Cl2 (88.0 mg, 0.11 mmol), and K2CO3 (446.8 mg, 3.23 mmol) in dioxane (4 mL) and water (1 mL) was stirred at 80 C for 2 h under nitrogen atmosphere. After cooling to room temperature, the residue was purified by reverse phase flash 33 chromatography with 40-70% MeCN in H2O to afford compound l3-a (60 mg, 21.64%) as a yellow solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1104455-41-5, Methyl 4-chloro-5-methylpicolinate.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; WANG, Guoqiang; SHEN, Ruichao; GRANGER, Brett; HE, Jing; XING, Xuechao; HE, Yong; LONG, Jiang; MA, Jun; WANG, Bin; OR, Yat, Sun; (99 pag.)WO2019/213244; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem