Category: 110860-92-9

Synthetic Route of 110860-92-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110860-92-9, name is 5,6-Dichloropyridin-3-ol. A new synthetic method of this compound is introduced below.

Sodium acetate (4.Og, 49.38mmoI) was added to a mixture of 5,6-dichloropyridin-3-ol (8g, 49.38mmol), Pd(OAc)2 (1.43g, 6.41 mmol) and Pd(dppf)C12 DCM complex (5.23g, 6.4lmmol) in EtOH (lOOmL) in an autoclave. The autoclave was filled with CO gas (22Opsi) and stirred at 90C for 6 h. The reaction mass was cooled to RT, excess gas evacuated in vacuo and the reaction mass was filtered through a celite bed. It was washed with EtOAc and the clear filtrate was concentrated under reduced pressure. Theresidue was purified by CC (0-40% EtOAc in PE) and the pure fractions were concentrated to get ethyl 3- chloro-5-hydroxypicolinate (9.2g, 93%) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110860-92-9, 5,6-Dichloropyridin-3-ol, and friends who are interested can also refer to it.

Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 110860-92-9 ,Some common heterocyclic compound, 110860-92-9, molecular formula is C5H3Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 1 3-(2-chloro-1,1,2-trifluoroethoxy)-5,6-dichloropyridine Chlorotrifluoroethylene was passed into a mixture of 16.4 g (0.1 mol) of 5,6-dichloro-3-pyridinol I/29 and 20 g (0.145 mol) of anhydrous potassium carbonate in 100 ml of absolute acetonitrile at 35 C. until starting material was no longer present. The solid was filtered off under suction, the solvent was removed by distillation, and the residue was taken up in ether and washed until neutral. After drying over MgSO4 and removal of the ether by distillation, the residue was distilled in a high vacuum. Yield 83% Boiling point 85 C./0.03 mbar

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110860-92-9, its application will become more common.

Reference:
Patent; Hoechst Aktiengesellschaft; US4756739; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem