Category: 110919-71-6

Adding a certain compound to certain chemical reactions, such as: 110919-71-6, 2-Amino-5-fluoro-6-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H7FN2, blongs to pyridine-derivatives compound. COA of Formula: C6H7FN2

Step 1 Ethyl 6-chloro-4-(5-fluoro-6-methylpyridin-2-ylamino) pyridazine-3-carboxylate A pressure tube was charged with ethyl 4,6-dichloropyridazine-3-carboxylate (300 mg, 1.36 mmol), 5-fluoro-6-methylpyridin-2-amine (257 mg, 2.04 mmol), and acetonitrile (8 mL) and then heated at 140 C. for 3 d. After cooling to room temperature the reaction mixture was concentrated in vacuo and the residue purified by chromatography (silica, 50 mum, 80 g, Analogix, 0 to 10% acetone in dichloromethane, 25 min) to afford ethyl 6-chloro-4-(5-fluoro-6-methylpyridin-2-ylamino)pyridazine-3-carboxylate (69 mg, 16%) as a yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 10.72 (br. s., 1H) 9.06 (s, 1H) 7.38 (s, 1H) 6.74-6.85 (m, 1H) 4.58 (q, J=7.07 Hz, 2H) 2.56 (d, J=3.03 Hz, 3H) 1.53 (t, J=7.07 Hz, 3H) 1.27 (s, 1H). LCMS (EI/CI) m/z: 311 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,110919-71-6, 2-Amino-5-fluoro-6-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael; US2013/178478; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 110919-71-6, Adding some certain compound to certain chemical reactions, such as: 110919-71-6, name is 2-Amino-5-fluoro-6-methylpyridine,molecular formula is C6H7FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 110919-71-6.

2-amino-5-fluoro-6-methylpyridine (0.559 mmol) and methyl 3-chloro-l-methyl-4-[[(li?)-2,2,2- trifluoro-l-methyl-ethyl]sulfamoyl]pyrrole-2-carboxylate (150 mg, 0.43 mmol) were dissolved in THF (10 mL). Lithium bis(trimethylsilyl)amide (1 M in THF) (1.29 mL, 1 M, 1.29 mmol) was added and the reaction mixture was stirred overnight. The reaction mixture was quenched with sat.NH4Cl (aq) (5 mL). The aqueous layer was extracted with CH2C12 (2 X 5 mL). The combined organic layers were evaporated to dryness and the residue was purified on silica using a heptane to EtOAc gradient. The obtained product was crystallized from CH2C12, triturated with diisopropylether and dried, resulting in compound 7 (83 mg) as a white powder. Method D; Rt: 1.96 min. m/z : 441.0 (M-H)” Exact mass: 442.0. 1H NMR (400 MHz, DMSO-d6) 5 ppm 1.19 (d, J=7.0 Hz, 3 H), 2.41 (d, J=2.9 Hz, 3 H), 3.77 (s, 3 H), 3.88 – 4.01 (m, 1 H), 7.65 (s, 1 H), 7.70 (t, J=9.0 Hz, 1 H), 7.98 (dd, J=9.0, 3.1 Hz, 1 H), 8.43 (br. s., 1 H), 10.68 (s, 1 H). MP: 173.1 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 110919-71-6, 2-Amino-5-fluoro-6-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; VANDYCK, Koen; HACHE, Geerwin Yvonne Paul; LAST, Stefaan Julien; ROMBOUTS, Geert; VERSCHUEREN, Wim Gaston; RABOISSON, Pierre Jean-Marie Bernard; WO2015/118057; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem