Related Products of 1120-90-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1120-90-7, name is 3-Iodopyridine, molecular formula is C5H4IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of 3-iodopyridine (4.00 g, 19.50 mmol), 4-methoxy benzeneboronic acid (3.26 g, 21.50 mmol) in toluene (100 mL) and EtOH (25 mL) under nitrogen, was added 2 M aqueous sodium carbonate (29 mL, 58.50 mmol). The solution was degassed, tetrakis(triphenylphosphine) palladium (0) (750 mg, 0.65 mmol) was added and the reaction was heated at 100C for 3 hours. The mixture was allowed to cool to room temperature, diluted with EtOAc (50 mL), washed with water (2 x 50 mL), saturated brine (1 x 50 mL), dried (Na2S04) and concentrated in vacuo. The crude product was purified by column chromatography on silica eluting with DCM to afford 3-(4- methoxyphenyl)pyridine (2.43 g, 67 %) as an oil. 1H NMR (400 MHz, CHCI3- ) delta ppm 3.84 (s, 3 H) 6.98 – 7.02 (m, 2 H) 7.32-7.35 (m, 1 H) 7.49 – 7.53 (m, 2 H) 7.81 – 7.84 (m, 1 H) 8.54 (d, 7=4.09, 1 H) 8.81 (s, 1 H) MS ES+: 186
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1120-90-7, 3-Iodopyridine.
Reference:
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BOUSBA, Sarah; GOLDBY, Anne; JENKINS, Kerry; KINSELLA, Natasha; TEALL, Martin; WO2015/19103; (2015); A1;,
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