Category: 1121-19-3

Sources of common compounds: 4-Methylpyridin-3-ol

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1121-19-3, 4-Methylpyridin-3-ol.

Electric Literature of 1121-19-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-19-3, name is 4-Methylpyridin-3-ol, molecular formula is C6H7NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-Methylpyridin-3-ol (5.00 g, J. Heterocyclic Chem. , 1985, 22, 1419) was added to cone. H2SO4 (25 mL) under ice- cooling (below 300C). Nitric acid (fuming, 2.2 mL) was added dropwise below 100C, and the mixture was stirred at 10-200C for 2 hr and then poured onto crashed ice. The mixture was adjusted to pH 2 by the addition of 8N NaOH and extracted with ethyl acetate (2 x) . The extracts were combined, dried over MgSO4 and concentrated, and the residue was chromatographed on silica gel using n-hexane/ethyl acetate as an eluent to give the title compound as yellow crystals (4.89 g) . mp. 87-880C.1H-NMR (300 MHz, DMSO-d6) delta: 2.31 (s, 3H), 7.56 (d, J = 4.2 Hz, IH), 7.93 (d, J = 4.2 Hz, IH), 10.55 (br, IH).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1121-19-3, 4-Methylpyridin-3-ol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2007/77961; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem