Category: 1121-60-4

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Picolinaldehyde

2-Pyridylbenzaldehyde (10.7 g, 0.1 mol), malonic acid (25.5 g, 0.25 mol) was added to a 100 ml round bottom flask.30 ml of pyridine was added as a solvent, magnetically stirred, and after all of it was dissolved, 1.6 g of piperidine was injected into the system.The oil bath was heated to 65 C and reacted for 3 h.The reaction was followed by thin layer chromatography, and after the reaction was completed, the reaction solution was cooled to 0-5 C.Pour into a mixture of ice and water containing concentrated hydrochloric acid (12 mol / l, 50 ml), a large amount of white solids precipitated, suction filtration,The desired 2-pyridine acrylic acid was obtained in a molar yield of 78%.

With the rapid development of chemical substances, we look forward to future research findings about 1121-60-4.

Reference:
Patent; Danyang Ning David Fang To Detect Co., Ltd.; Wei Qian; (4 pag.)CN109748851; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1121-60-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1121-60-4, name is Picolinaldehyde. A new synthetic method of this compound is introduced below.

General procedure: To a mixture of 1,2-phenylenediamines (1.0 mmol) andaldehydes (1.1 mmol) in ethanol, 25 mol % of Ag2CO3/Celite (3 mL) was added. The resulting mixture was stirredat 70 C for 3 h. After this time, the reaction mixture wasdiluted with ethanol (50 mL) and the catalyst was separatedby filtration. Water was then added to the organic layer, andthe products were filtered and washed with water. All of theproducts are known compounds and characterized easily bycomparison with melting point, IR, [1-6] H NMR spectraldata reported in literature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1121-60-4, Picolinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Soleimani, Ebrahim; Khodaei, Mohammad Mehdi; Yazdani, Hossein; Saei, Parisa; Zavar Reza, Javad; Journal of the Iranian Chemical Society; vol. 12; 7; (2015); p. 1281 – 1285;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1121-60-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, molecular weight is 107.11, as common compound, the synthetic route is as follows.

General procedure: Equimolar mixture of pyridine carboxaldehyde deriva-tives (1 mmol) and sodium metabisulphite (1 mmol) in DMF (10 mL) was stirred for 10 to 15 min, followed by the addi-tion of o-phenylene diamine/2-aminothiophenol (1 mmol) into it and refluxed for 3 h. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was poured into crushed ice, precipitates were formed which were collected by filtration to afford compounds 1-27 in good yields. Recrystallization from methanol yielded pure crystals.

The chemical industry reduces the impact on the environment during synthesis 1121-60-4, I believe this compound will play a more active role in future production and life.

Reference:
Article; Khan, Momin; Ahmad, Riaz; Rehman, Gauhar; Gul, Naeem; Shah, Sana; Salar, Uzma; Perveen, Shahnaz; Khan, Khalid Mohammed; Letters in drug design and discovery; vol. 16; 9; (2019); p. 984 – 993;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1121-60-4 ,Some common heterocyclic compound, 1121-60-4, molecular formula is C6H5NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a typical experiment,a mixture of aromatic aldehyde 2 (1mmol) and o-phenylenediamine (1) (1 mmol) was taken in a test tube.The reaction mixture was stirred on magnetic stirrer in concentrated solar radiation (CSR) for 20-30 minutes and monitored by TLC. On completion of the reaction, the reaction mixture was cooled to room temperature.The 2-aryl-1H-benzimidazoles 3 were isolated by using column chromatography over Silica gel using hexane-EtOAc as eluent as and when required.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1121-60-4, its application will become more common.

Reference:
Article; Harsh, Simran; Yusuf, Mohamad; Sharma, Rohit; Kumar, Yogesh; Kumar, Rupesh; Arkivoc; vol. 2018; 7; (2018); p. 119 – 130;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1121-60-4, Picolinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1121-60-4, blongs to pyridine-derivatives compound. Product Details of 1121-60-4

General procedure: To a solution of 4-methoxybenzaldehyde (1mmol, 0.136 g) in dry DMF (5mL), hydroxylamine hydrochloride (3 mmol, 0.208 g) was added with stirring for 15 min at 120 C. HAP(at)AEPH2-SO3H nanocatalyst (8 mol-%, 0.08 g) was then added to the resultant solution. After completion of the reaction (which was monitored byTLC), cooling, and separation of the nanocatalyst by centrifugation, the reaction mixture was poured into water (10mL). The resulting mixture was extracted with ethyl acetate (310mL) and dried over sodium sulfate. After evaporation of the solvent, the crude product was purified by thin-layer chromatography using n-hexane/ethyl acetate (4 : 1) as eluent to afford 4-methoxybenzonitrile (0.130 g, 98%).

The synthetic route of 1121-60-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Masjed, Samane Memar; Akhlaghinia, Batool; Zarghani, Monireh; Razavi, Nasrin; Australian Journal of Chemistry; vol. 70; 1; (2017); p. 33 – 43;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1121-60-4, name is Picolinaldehyde. A new synthetic method of this compound is introduced below., 1121-60-4

General procedure: Ce(NO3)3¡¤6H2O (0.15 mmol) was added to a mixture of the diamine 1 (0.5 mmol) and the appropriate aldehyde 2 (0.6 mmol) in DMF (3 mL). The reaction mixture was stirred at 80C. The reaction progress was monitored by TLC. After complete consumption of the starting materials, the reaction mixture was cooled to rt, water (15 mL) was added and the resulting mixture was extracted with EtOAc (3 10 mL). The combined organic phases were successively washed with water and brine, and dried over anhydrous MgSO4. After filtration, the solvent was removed under reduced pressure. The product was purified chromatographically (hexane- EtOAc, 70:30).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1121-60-4, Picolinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Martins, Guilherme M.; Puccinelli, Thiago; Gariani, Rogerio A.; Xavier, Fernando R.; Silveira, Claudio C.; Mendes, Samuel R.; Tetrahedron Letters; vol. 58; 20; (2017); p. 1969 – 1972;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1121-60-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: to a solution of 2-pyridinecarbaldehyde 1 (54 mg, 0.5 mmol) and ammonium acetate (385mg, 5.0 mmol) in MeCN )6ml), was added trimethylphenylammonium tribromide (376 mg, 1.0 mmol) at room temperature. after stirring for 21 h at rt, the reaction mixture was treated with 0.5 M aq Na2S2O3(10 ml), 1.0 M NaHCO3 )15 ml) and extracted with EtOAc (60 mL). The organic layer was washed with 0.5 M Na2S2O3 and successively washed with saturated aq.NaCl, and dried over MgSO4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1121-60-4, Picolinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sayama, Shinsei; Heterocycles; vol. 92; 10; (2016); p. 1796 – 1802;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1121-60-4, name is Picolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. 1121-60-4

The 2-pyridine benzaldehyde (10.7g, 0.1mol),Malonic acid (25.5g, 0.25mol) was added to a 100ml round bottom flask,Add 30ml of pyridine as a solvent and stir it magnetically. After all of it is dissolved,Inject 1.6g piperidine into the system, warm the oil bath to 65 C, and react for 3h.Follow the reaction by thin layer chromatography. After the reaction is complete, cool the reaction solution to 0-5 C .Poured into a mixture of ice and water containing concentrated hydrochloric acid (12mol / l, 50ml), a large amount of white solid was precipitated and filtered with suction to obtain the desired 2-pyridineacrylic acid in a molar yield of 78%.

Statistics shows that 1121-60-4 is playing an increasingly important role. we look forward to future research findings about Picolinaldehyde.

Reference:
Patent; Changzhou Chuanyou Environmental Protection Technology Co., Ltd.; Ni Jun; (4 pag.)CN110746346; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1121-60-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-(1H-Imidazol-2-yl)-pyridine A round bottom flask was charged with 2-pyridinecarboxaldehyde (5.0 g), glyoxal (10.7 mL, 40% in water), and methanol (100 mL). This mixture was stirred at room temp as 26 mL of concentrated aqueous ammonia was added portion-wise. After 1 h, the solvents were removed, and the remaining brown residue was recrystallized in acetonitrile (ca. 40 mL). The product 2-(1H-Imidazol-2-yl)-pyridine was collected as brown crystals.

The chemical industry reduces the impact on the environment during synthesis 1121-60-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Leivers, Martin Robert; Lauchli, Ryan; US2010/29655; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1121-60-4, Adding a certain compound to certain chemical reactions, such as: 1121-60-4, Picolinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1121-60-4, blongs to pyridine-derivatives compound.

General procedure: In a typical experiment,a mixture of aromatic aldehyde 2 (1mmol) and o-phenylenediamine (1) (1 mmol) was taken in a test tube.The reaction mixture was stirred on magnetic stirrer in concentrated solar radiation (CSR) for 20-30 minutes and monitored by TLC. On completion of the reaction, the reaction mixture was cooled to room temperature.The 2-aryl-1H-benzimidazoles 3 were isolated by using column chromatography over Silica gel using hexane-EtOAc as eluent as and when required.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1121-60-4, its application will become more common.

Reference:
Article; Harsh, Simran; Yusuf, Mohamad; Sharma, Rohit; Kumar, Yogesh; Kumar, Rupesh; Arkivoc; vol. 2018; 7; (2018); p. 119 – 130;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem