Category: 1121-60-4

1121-60-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of aldehyde (1mmol) and o-phenylenediamine 1a (1mmol, 108.1 mg) in water (1 mL) were added to dispersed solution of GO (100 wt%, 108.7 mg) in water (2 mL) and the reaction mixture was stirred at 60 C forappropriate time (Table 2). After completion of the reaction(monitored by TLC using n-hexane/EtOAc 9:1 as eluent), theGO was separated by filtration and the solution was extractedwith ethyl acetate (2 5 mL). The GO was washed with warmethanol (about 75 C, 5 10 mL) and then organic layers(EtOAc and ethanol) were combined and dried over anhydroussodium sulfate. The solvents were removed under reducedpressure and the residue left out was purified by chromatographyon a short column of silica gel eluted with n-hexane/ethyl acetate (9:1) to give the corresponding benzimidazoles 2in 78-95%yield (Table 2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1121-60-4, Picolinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Khalili, Dariush; Banazadeh, Ali Reza; Bulletin of the Chemical Society of Japan; vol. 88; 12; (2015); p. 1693 – 1706;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1121-60-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1121-60-4, name is Picolinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An ice-cold solution of the appropriate aldehyde(2-pyridinecarboxyaldehyde (4.668 mmol) or 2-quinolinecarboxyaldehyde(3.181 mmol) in 5 mL ethanol was added to an ice cold solution of 40% aqueous glyoxal (0.2 mL) in 5 mL ethanol,and then ice-cold concentrated aqueous NH4OH solution(0.15 mL) was added immediately. This solution was stirred at 0 C for 1 h, warmed to room temperature, and stirred for an additional 5 h. The solvent was removed under reduced pressure, andthe resulting solution was extracted several times with diethyl ether. The combined organic extracts were evaporated under reduced pressure and crystalline solids were obtained upon recrystallization with diethyl ether.

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Reference:
Article; Sinha, Soumalya; Berdichevsky, Ellan K.; Warren, Jeffrey J.; Inorganica Chimica Acta; vol. 460; (2017); p. 63 – 68;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem