Category: 112193-41-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112193-41-6, name is 5-Bromonicotinohydrazide. A new synthetic method of this compound is introduced below., Safety of 5-Bromonicotinohydrazide

To a solution 5-bromonicotinohydrazide (2 g, 9 mmol) in dioxane (48 mL) was added sodium bicarbonate (0.78 g, 9.2 mmol) and 20 mL of water. The reaction mixture was allowed to stir for 10 min. and then cynogen bromide (1.17g, 10 mmol) was added. The resulting clear solution was allowed to stir overnight at ambient temperature. At the conclusion of this period, a pinkish precipitate was collected by filtration to yield 5-(5-bromopyridin-3-yl)-l,3,4-oxadiazol-2-amine (3.4 g, 72 % yield). LCMS Method Y: retention time 1.43 min; [M+l] = 239.0, 241.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 112193-41-6, 5-Bromonicotinohydrazide.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; LLOYD, John; FINLAY, Heather; JIANG, Ji; NEELS, James; DHONDI, Naveen Kumar; GUNAGA, Prashantha; BANERJEE, Abhisek; ADISECHAN, Ashokkumar; WO2011/28741; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112193-41-6, name is 5-Bromonicotinohydrazide. A new synthetic method of this compound is introduced below., Computed Properties of C6H6BrN3O

Example 251-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-4-chloro-2- (difluoromethyl)-1H-indole-5-carbonitrile A. 5-Bromo-A/’-(chloroacetyl)-3-pyridinecarbohydrazide; To an ice-cold suspension of 5-bromo-3-pyhdinecarbohydrazide (3.0 g, 13.88 mmol) in anhydrous CH2CI2 (60 ml_) was added 4-methyl-morpholine (2.1 g, 20.82 mmol), followed by dropwise addition of chloroacetyl chloride (1.88 g,16.67 mmol). The cold bath was then removed and the mixture stirred at rt for 15 h. Heavy precipitation occurred and the mixture was diluted with additional CH2CI2 (50 ml_) and stirring continued for 24 h. The solids were collected by filtration and washed with CH2CI2 to afford the title compound (3.66 g, 90% yield): MS (ES) m/z 292 and 294 (M+1 Br isotopes).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 112193-41-6, 5-Bromonicotinohydrazide.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/42571; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 112193-41-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112193-41-6, name is 5-Bromonicotinohydrazide, molecular formula is C6H6BrN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 102 4-[1-(3-Aminopropyl)-5-fluoro-indol-3-yl]-5-(5-bromo-pyridin-3-yl)-2,4-dihydro-[1,2,4]triazol-3-one hydrochloride The title compound was prepared by the method described in Example 45 starting from the product of Example 45d) and 5-bromo-nicotinic acid hydrazide. 1H NMR (400 MHz, DMSO-d6): delta12.45 (1H, s); 8.68 (1H, d); 8.48 (1H, d); 8.00 (1H, m); 7.89 (3H, bs); 7.80 (1H, s); 7.70 (1H, m); 7.16 to 7.09 (2H, m); 4.35 (2H, m); 2.75 (2H, m); 2.04 (2H, m). APCI-MS m/z: 431 [MH+].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112193-41-6, 5-Bromonicotinohydrazide.

Reference:
Patent; Astrazeneca AB; US6492406; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 112193-41-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 112193-41-6, name is 5-Bromonicotinohydrazide, molecular formula is C6H6BrN3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 102 4-[1-(3-Aminopropyl)-5-fluoro-indol-3-yl]-5-(5-bromo-pyridin-3-yl)-2,4-dihydro-[1,2,4]triazol-3-one hydrochloride The title compound was prepared by the method described in Example 45 starting from the product of Example 45d) and 5-bromo-nicotinic acid hydrazide. 1H NMR (400 MHz, DMSO-d6): delta12.45 (1H, s); 8.68 (1H, d); 8.48 (1H, d); 8.00 (1H, m); 7.89 (3H, bs); 7.80 (1H, s); 7.70 (1H, m); 7.16 to 7.09 (2H, m); 4.35 (2H, m); 2.75 (2H, m); 2.04 (2H, m). APCI-MS m/z: 431 [MH+].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 112193-41-6, 5-Bromonicotinohydrazide.

Reference:
Patent; Astrazeneca AB; US6492406; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112193-41-6, name is 5-Bromonicotinohydrazide. A new synthetic method of this compound is introduced below., Product Details of 112193-41-6

To a solution 5-bromonicotinohydrazide (2 g, 9 mmol) in dioxane (48 mL) was added sodium bicarbonate (0.78 g, 9.2 mmol) and 20 mL of water. The reaction mixture was allowed to stir for 10 min. and then cynogen bromide (1.17g, 10 mmol) was added. The resulting clear solution was allowed to stir overnight at ambient temperature. At the conclusion of this period, a pinkish precipitate was collected by filtration to yield 5-(5-bromopyridin-3-yl)-l,3,4-oxadiazol-2-amine (3.4 g, 72 % yield). LCMS Method Y: retention time 1.43 min; [M+l] = 239.0, 241.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 112193-41-6, 5-Bromonicotinohydrazide.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; LLOYD, John; FINLAY, Heather; JIANG, Ji; NEELS, James; DHONDI, Naveen Kumar; GUNAGA, Prashantha; BANERJEE, Abhisek; ADISECHAN, Ashokkumar; WO2011/28741; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem