Category: 1122-54-9

Sheng, Min; Fujita, Shu; Yamaguchi, Sho; Yamasaki, Jun; Nakajima, Kiyotaka; Yamazoe, Seiji; Mizugaki, Tomoo; Mitsudome, Takato published their research in JACS Au in 2021. The article was titled 《Single-Crystal Cobalt Phosphide Nanorods as a High-Performance Catalyst for Reductive Amination of Carbonyl Compounds》.Related Products of 1122-54-9 The article contains the following contents:

Herein, the successful synthesis of single-crystal cobalt phosphide nanorods (Co2P NRs) containing coordinatively unsaturated Co-Co active sites, which serve as a new class of air-stable, highly active, and reusable heterogeneous catalysts for the reductive amination of carbonyl compounds was reported. The Co2P NR catalyst showed high activity for the transformation of a broad range of carbonyl compounds to their corresponding primary amines using an aqueous ammonia solution or ammonium acetate as a green amination reagent at 1 bar of H2 pressure; these conditions were far milder than previously reported. The air stability and high activity of the Co2P NRs was noteworthy, as conventional Co catalysts were air-sensitive (pyrophorous) and show no activity for this transformation under mild conditions. P-alloying was therefore of considerable importance for nanoengineering air-stable and highly active non-noble-metal catalysts for organic synthesis. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Fan, Weibin; Zhang, Yuan; Li, Yinghua; Zhang, Wei; Huang, Deguang published an article in ChemSusChem. The title of the article was 《Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy》.Computed Properties of C7H7NO The author mentioned the following in the article:

A solvent-free method for the synthesis of quaternary ammonium salts (QAS) such as 1-(2-Iodo-1-phenylethyl)-4-pyridinium triiodide I [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = H, 4-OMe, 4-C(O)OMe, etc.; X = H, N; Y = H, N] by iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages lied in energy-saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Generated QAS converted to pyrroles such as II [R1 = Ph, 4-MeC6H4, 2-ClC6H4, etc.; R2 = 5-SMe, C(O)Ome, C(O)Ph, etc.]. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chems., such as biol. protease inhibitors, anti-cancer agents, and organic fluorescent materials. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Xue; Bai, Fang; Liu, Chaogan; Ma, Xiaowei; Gu, Chengzhi; Dai, Bin published their research in Organic Letters in 2021. The article was titled 《Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls》.Safety of 4-Acetylpyridine The article contains the following contents:

An efficient electrochem. method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, e.g., p-chlorotoluene, methylheteroarenes, e.g., 6-methylquinoline and benzylic (hetero)methylenes, e.g., p-ethyltoluene could be converted into the desired aryl aldehydes, e.g., 4-chlorobenzaldehyde/e.g., quinoline-6-carbaldehyde and aryl ketones, e.g., 1-(p-tolyl)ethan-1-one in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis, structure and physical properties of (trans-TTF-py2)1.5(PF6)·EtOH: a molecular conductor with weak CH···N hydrogen bondings》 was published in Crystals in 2020. These research results belong to Koyama, Shohei; Kawai, Morio; Takaishi, Shinya; Yamashita, Masahiro; Hoshino, Norihisa; Akutagawa, Tomoyuki; Kanno, Manabu; Iguchi, Hiroaki. Related Products of 1122-54-9 The article mentions the following:

The studies of crystal structures with hydrogen bonds have been actively pursued because of their moderate stabilization energy for constructing unique structures. In this study, we synthesized a mol. conductor based on 2,6-bis(4-pyridyl)-1,4,5,8-tetrathiafulvalene (trans-TTF-py2). Two pyridyl groups were introduced into the TTF skeleton toward the structural exploration in TTF-based mol. conductors involved by hydrogen bonds. In the obtained mol. conductor, (trans-TTF-py2)1.5(PF6)·EtOH, short contacts between the pyridyl group and the hydrogen atom of the TTF skeleton were observed, indicating that hydrogen bonding interactions were introduced in the crystal structure. Spectroscopic measurements and conductivity measurement revealed semiconducting behavior derived from p-stacked trans-TTF-py2 radical in the crystal structure. Finally, these results are discussed with the quantified hydrogen bonding stabilization energy, and the band calculation of the crystal obtained from d. functional theory calculation4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Safety of 4-AcetylpyridineIn 2021 ,《Chiral Iron(II)-Catalysts within Valinol-Grafted Metal-Organic Frameworks for Enantioselective Reduction of Ketones》 appeared in ACS Catalysis. The author of the article were Antil, Neha; Akhtar, Naved; Newar, Rajashree; Begum, Wahida; Kumar, Ajay; Chauhan, Manav; Manna, Kuntal. The article conveys some information:

The development of highly efficient and enantioselective heterogeneous catalysts based on earth-abundant elements and inexpensive chiral ligands is essential for environment-friendly and economical production of optically active compounds The authors report a strategy of synthesizing chiral amino alc.-functionalized metal-organic frameworks (MOFs) to afford highly enantioselective single-site base-metal catalysts for asym. organic transformations. The chiral MOFs (vol-UiO) were prepared by grafting of chiral amino alc. such as L-valinol within the pores of aldehyde-functionalized UiO-MOFs via formation of imine linkages. The metalation of vol-UiO with FeCl2 in THF gives amino alc. coordinated octahedral FeII species of vol-FeCl(THF)3 within the MOFs as determined by x-ray absorption spectroscopy. Upon activation with LiCH2SiMe3, vol-UiO-Fe catalyzed hydrosilylation and hydroboration of a range of aliphatic and aromatic carbonyls to afford the corresponding chiral alcs. with enantiomeric excesses up to 99%. Vol-UiO-Fe catalysts have high turnover numbers of up to 15,000 and could be reused at least 10 times without any loss of activity and enantioselectivity. The spectroscopic, kinetic, and computational studies suggest iron-hydride as the catalytic species, which undergoes enantioselective 1,2-insertion of carbonyl to give an iron-alkoxide intermediate. The subsequent σ-bond metathesis between Fe-O bond and Si-H bond of silane produces chiral silyl ether. This work highlights the importance of MOFs as the tunable mol. material for designing chiral solid catalysts based on inexpensive natural feedstocks such as chiral amino acids and base-metals for asym. organic transformations. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《C1-Symmetric PNP Ligands for Manganese-Catalyzed Enantioselective Hydrogenation of Ketones: Reaction Scope and Enantioinduction Model》 was written by Zeng, Liyao; Yang, Huaxin; Zhao, Menglong; Wen, Jialin; Tucker, James H. R.; Zhang, Xumu. Application of 1122-54-9 And the article was included in ACS Catalysis in 2020. The article conveys some information:

A family of ferrocene-based chiral PNP ligands I (R = t-Bu, cyclohexyl, Ph, R’ = Ph; R = Ph, R’ = H, i-Pr, PhCH2) has been reported. These tridentate ligands were successfully applied in Mn-catalyzed asym. hydrogenation of ketones with high enantioselectivities (92-99% ee for aryl alkyl ketones) as well as high efficiencies (TON up to 2000). In addition, dialkyl ketones could also be hydrogenated smoothly. Manganese intermediates that might be involved in the catalytic cycle were analyzed. DFT calculation was carried out to help understand the chiral induction model. The Mn/PNP catalyst could discriminate two groups with different steric properties by deformation of the phosphine moiety in the flexible 5-membered ring. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《General synthesis of primary amines via reductive amination employing a reusable nickel catalyst》 were Hahn, G.; Kunnas, P.; de Jonge, N.; Kempe, R.. And the article was published in Nature Catalysis in 2019. Application of 1122-54-9 The author mentioned the following in the article:

A nanostructured nickel catalyst was reported for the general and selective synthesis of primary amines via reductive amination, employing ammonia dissolved in water. The catalyst, which operated at low temperature and pressure, was highly active, reusable and easy to handle. The synthesis from a specific nickel complex and γ-Al2O3 was straightforward, with the ligand-metal combination of this complex being crucial. Aldehydes (including purely aliphatic ones), aryl-alkyl, dialkyl and diaryl ketones could all be converted smoothly into primary amines. In addition, the amination of pharmaceuticals, bioactive compounds and natural products was demonstrated. Many functional groups-including hydrogenation-sensitive examples-were tolerated. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chromism, positional, conformational and structural isomerism in a series of Zn(II) and Cd(II) coordination polymers based on methylated azine N,N’-donor linkers》 was written by Lozovan, Vasile; Kravtsov, Victor Ch.; Gorincioi, Elena; Rotaru, Andrei; Coropceanu, Eduard B.; Siminel, Nikita; Fonari, Marina S.. Reference of 4-AcetylpyridineThis research focused onzinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer preparation luminescence; thermal stability zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer; crystal structure zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer. The article conveys some information:

Seven new coordination polymers [Zn(I)2(4-bpmhz)]n (1), [Cd(I)2(4-bpmhz)]n (2), [Zn(I)2(3-bpmhz)]n (3), [Cd(I)2(3-bpmhz)2]n (4), [Zn(NO3)2(H2O)2(4-bpmhz)]n·0.5n(EtOH) (5), [Cd(NO3)2(4-bpmhz)3/2(MeOH)]n·0.5nH2O (6) and [Zn(NO3)2(3-bpmhz)2]n (7) were prepared following the reactions of the zinc and cadmium iodide or nitrate salts with the methylated azine ligands of the bis-monodentate N,N’-donor type, 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (4-bpmhz) and 1,2-bis(1-(pyridin-3-yl)ethylidene)hydrazine (3-bpmhz). The single-crystal X-ray diffraction studies show that compounds 1-5, and 7 display 1D chain structures, while compound 6 shows a 2D coordination network, and both 4-bpmhz and 3-bpmhz act as bidentate bridging ligands. The crystals 1 and 2 are isomorphous, and differ by the metal cation only. The single coordination chains in 1-3 have zigzag structures; they are linear in 5, while 4 and 7 display similar double-chain structures. The crystal packing in 5 and 6 provides cavities occupied by solvent mols., ethanol and water. The compounds were characterized in the solid state and in solution by spectroscopic (FTIR, UV-Vis, NMR) methods; the solid state emissive properties were studied for all compounds, while their thermal stability and behavior were investigated by thermogravimetry under inert atm., while the thermochromism for several compounds was registered and discussed. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Reference of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Zhang, Lin; Zhang, Ling; Chen, Qian; Li, Linlin; Jiang, Jian; Sun, Hao; Zhao, Chong; Yang, Yuanyong; Li, Chun published an article in Organic Letters. The title of the article was 《Cinchona-Alkaloid-Derived NNP Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones》.HPLC of Formula: 1122-54-9 The author mentioned the following in the article:

Herein, a series of novel and easily accessed cinchona-alkaloid-based NNP ligands I [R = cyclohexyl, Ph, 2-MeOC6H4, etc.; R1 = H, MeO] was developed in two steps. By combining [Ir(COD)Cl]2, 39 ketones including aromatic, heteroaryl, and alkyl ketones were hydrogenated, all affording valuable chiral secondary alcs. with 96.0-99.9% ee. A plausible reaction mechanism was discussed by NMR, HRMS, DFT and an activating model involving trihydride was verified. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Zhuang; Cheng, Xian-Yan; Yang, Ning-Yuan; Chen, Ji-Jun; Tang, Wen-Yue; Bian, Jun-Qian; Cheng, Yong-Feng; Li, Zhong-Liang; Gu, Qiang-Shuai; Liu, Xin-Yuan published their research in Organometallics in 2021. The article was titled 《A Cobalt-Catalyzed Enantioconvergent Radical Negishi C(sp3)-C(sp2) Cross-Coupling with Chiral Multidentate N,N,P-Ligand》.Quality Control of 4-Acetylpyridine The article contains the following contents:

A cobalt-catalyzed enantioconvergent radical Negishi C(sp3)-C(sp2) cross-coupling of racemic benzyl chlorides with arylzinc reagents has been developed in good yield with moderate enantioselectivities. This strategy provides an expedient access toward a range of enantioenriched 1,1-diarylmethanes. Key to this discovery is the utilization of a chiral multidentate anionic N,N,P-ligand to strongly coordinate with the cobalt catalyst and tune its chiral environment, thus achieving the enantiocontrol over the highly reactive prochiral alkyl radical species. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Quality Control of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Quality Control of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem