Category: 1122-54-9

Mihajlovic-Lalic, Ljiljana E.’s team published research in Journal of Coordination Chemistry in 2022 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Synthetic Route of C7H7NO

Synthetic Route of C7H7NOIn 2022 ,《(Electro)chemical and antimicrobial characterization of novel Ru(II) bipyridine complexes with acetylpyridine analogs》 was published in Journal of Coordination Chemistry. The article was written by Mihajlovic-Lalic, Ljiljana E.; Stankovic, Dalibor; Novakovic, Irena; Grguric-Sipka, Sanja. The article contains the following contents:

Three ruthenium-bipyridine complexes (1-3) carrying acetylpyridine ligand unit were synthesized in methanol via the reaction of [RuCl2(bpy)2] with corresponding acetylpyridine (2-, 3-, and 4-acpy). Obtained complexes were characterized by (1H and 13C) NMR and IR spectroscopy, MS spectrometry, UV-visible spectrophotometry, and cyclic voltammetry. Their structural characterization revealed bidentate coordination mode for 2-acpy while 3- and 4-acpy acted as monodentate ligands. The electrochem. profile of newly synthesized compounds was studied by cyclic voltammetry which confirmed their electrochem. activity. Voltammetric responses within the -1.20 < Ep < 1.50 v range of potentials were summarized in two major events: Ru(II)→Ru(III) oxidation spotted at apparatus ΔEp = 0.65 v and successive reductions of bpy units located from -0.79 v to 0.47 v (vs. Ag/AgCl (3 M) electrode). The DNA-binding activity of the complexes was evaluated by both UV-visible spectrophotometry and cyclic voltammetry indicating DNA-intercalation with a slight contribution of electrostatic interactions. Furthermore, antimicrobial activity was tested against bacterial and fungal strains, for which moderate activity was observed Assessment of in vitro toxicity against freshly hatched nauplii of Artemia salina as well as radical scavenging capacity was evaluated. The test compounds showed neither toxicity nor antioxidant activity. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Gregson, Charlotte H. U.’s team published research in Angewandte Chemie, International Edition in 2021 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C7H7NO

Electric Literature of C7H7NOIn 2021 ,《Divergent, Strain-Release Reactions of Azabicyclo[1.1.0]butyl Carbinols: Semipinacol or Spiroepoxy Azetidine Formation》 was published in Angewandte Chemie, International Edition. The article was written by Gregson, Charlotte H. U.; Noble, Adam; Aggarwal, Varinder K.. The article contains the following contents:

The azetidine moiety is a privileged motif in medicinal chem. and new methods that access them efficiently are highly sought after. Towards this goal, we have found that azabicyclo[1.1.0]butyl carbinols, readily obtained from the highly strained azabicyclo[1.1.0]butane (ABB), can undergo divergent strain-release reactions upon N-activation. Treatment with trifluoroacetic anhydride or triflic anhydride triggered a semipinacol rearrangement to give keto 1,3,3-substituted azetidines. More than 20 examples were explored, enabling us to evaluate selectivity and the migratory aptitude of different groups. Alternatively, treatment of the same alcs. with benzyl chloroformate in the presence of NaI led to iodohydrin intermediates which gave spiroepoxy azetidines upon treatment with base. The electronic nature of the activating agent dictates which pathway operates. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Electric Literature of C7H7NO) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Electric Literature of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cao, Bing-Jun’s team published research in Acta Crystallographica, Section C: Structural Chemistry in 2021 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 1122-54-9

Cao, Bing-Jun; Li, Ran; Huang, Xi-He published their research in Acta Crystallographica, Section C: Structural Chemistry in 2021. The article was titled 《Synthesis, structure and photophysical properties of two tetranuclear copper(I) iodide complexes based on acetylpyridine and diphosphine mixed ligands》.Product Details of 1122-54-9 The article contains the following contents:

Two copper(I) iodide tetramers, namely, [μ2-1,3-bis(diphenylphosphanyl)propane-κ2P:P′]di-μ3-iodido-di-μ2-iodido-[1-(pyridin-3-yl)ethan-1-one-κN]tetracopper(I) dichloromethane disolvate, [Cu4I4(C6H7NO)2(C27H26P2)2]·2CH2Cl2 (CuL3), and [μ2-1,3-bis(diphenylphosphanyl)propane-κ2P:P′]di-μ3-iodido-di-μ2-iodido-[1-(pyridin-4-yl)ethan-1-one-κN]tetracopper(I), [Cu4I4(C6H7NO)2(C27H26P2)2] (CuL4), have been synthesized from reactions of CuI, 1,3-bis(diphenylphosphanyl)propane (dppp) and 3- or 4-acetylpyridine (3/4-acepy). The complexes were characterized by elemental anal., IR spectroscopy, single-crystal X-ray diffraction (XRD), powder XRD and photoluminescence spectroscopy. Both complexes possess a stair-step [Cu4I4] cluster structure with a crystallog. inversion center located in the middle of a Cu2I2 ring (Z′ = 1/2). The dppp ligands each adopt a bidentate coordination mode that bridges two CuI centers on one side of the [Cu4I4] cluster and the acepy ligands act as terminal ligands. The solid-state samples of similar complexes show highly efficiency thermally activated delayed fluorescence (TADF) at room temperature At ambient temperature, both CuL3 and CuL4 exhibit photoluminescence, with a maximum emission in the region 560-580 nm and with short emissive decay times, but only phosphorescence was observed at 77 K. The narrow gaps between the higher lying singlet state and the triplet state, ΔE(S1 – T1), also confirm the presence of TADF. Structure anal. and consideration of photoluminescence indicates that the position of the acetyl group on the heterocyclic ligand has an obvious influence on the structural arrangement, on intermol. interactions and on the observed photophys. properties. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liang, Chunjing’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2020 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Computed Properties of C7H7NO

《An activity-based two-photon fluorescent probe for real-time and reversible imaging of oxidative stress in the rat brain》 was written by Liang, Chunjing; Chen, Xianghan; Tang, Qiao; Ji, Wenliang; Jiang, Ying; Mao, Lanqun; Wang, Ming. Computed Properties of C7H7NOThis research focused ontwo photon fluorescent probe imaging oxidative stress brain. The article conveys some information:

The real-time and reversible detection of cellular glutathione and oxidative stress challenges the study of the redox homeostasis of biol. systems. The authors report herein a modular approach to design the Michael addition between glutathione and coumarin derivatives for fluorescence imaging of the reversible and dynamic change of oxidative stress in living cells and the rat brain. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Looga, A. M.’s team published research in Austin Journal of Analytical and Pharmaceutical Chemistry in 2019 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C7H7NO

In 2019,Austin Journal of Analytical and Pharmaceutical Chemistry included an article by Looga, A. M.; Ambassa, P.; Kamga, J.; Hortense, GK.; Ngadjui, B. T.; Ngameni, B.. COA of Formula: C7H7NO. The article was titled 《Synthesis and evaluation of antimicrobial properties of some novel indole pyridine based chalcones》. The information in the text is summarized as follows:

A series of novel substituted indolylchalcone derivatives (E)-I (R = H, Me, Ar = pyridin-3-yl, pyridin-4-yl) were synthesized via Claisen-Schmidt condensation between indole-3-carbaldehyde and N-methylindole-3-carbaldehyde and 3- and 4-pyridinylacetophenones. All the compounds were screened for their antibacterial and antifungal activity against six different bacterial strains – Escherichia coli ATCC 25922, Klebsiella pneumonia ATCC 700603, Staphylococcus aureus ATCC 25923, Proteus mirabilis, Salmonella typhi, Pseudomonas aeruginosa – and against one fungal strain, Candida albicans. The results reveal that all the compounds exhibited moderate to good antibacterial and antifungal activities. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Granifo, Juan’s team published research in Acta Crystallographica, Section C: Structural Chemistry in 2019 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 1122-54-9

《Structural characterization of a hybrid terpyridine-pyrazine ligand and its one-dimensional ZnII coordination polymer: a computational approach to conventional and nonconventional intermolecular interactions》 was written by Granifo, Juan; Gavino, Ruben; Suarez, Sebastian; Baggio, Ricardo. Product Details of 1122-54-9This research focused onzinc terpyridine pyrazine coordination polymer crystal structure intermol interaction; Hirshfeld surface; computational chemistry; crystal structure; energy framework; enrichment ratio; interaction strength hierarchy; one-dimensional coordination polymer; terpyridine-pyrazine. The article conveys some information:

The structures of a new hybrid terpyridine-pyrazine ligand, namely 4′-[4-(pyrazin-2-yl)phenyl]-4,2′:6′,4′′-terpyridine (L2), C25H17N5, and its one-dimensional coordination polymer catena-poly[[bis(acetylacetonato-κ2O,O′)zinc]-μ-4′-[4-(pyrazin-2-yl-κN4)phenyl]-4,2′:6′,4′′-terpyridine-κN1], [Zn(C5H7O2)2(C25H17N5)]n or [Zn(acac)2(L2)]n (Hacac is acetylacetone), are reported. Packing interactions in both crystal structures are analyzed using Hirshfeld surface and enrichment ratio techniques. For the simpler structure of the monomeric ligand, further studies on the interaction hierarchy using the energy framework approach were made. The result was a complete picture of the intermol. interaction landscape, which revealed some subtle details, for example, that some weak (at first sight negligible) C-H···N interactions in the structure of free L2 play a relevant role in the crystal stabilization. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhu, Hongmei’s team published research in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019 | CAS: 1122-54-9

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 1122-54-9

The author of 《An effective surface modification strategy with high reproducibility for simultaneously improving efficiency and stability of inverted MA-free perovskite solar cells》 were Zhu, Hongmei; Wu, Shaohang; Yao, Jiaxu; Chen, Rui; Pan, Ming; Chen, Weitao; Zhou, Jing; Zhang, Wenjun; Wang, Tao; Chen, Wei. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2019. Application of 1122-54-9 The author mentioned the following in the article:

Perovskite solar cells (PSCs) have become the front-running photovoltaic technol. and have triggered enormous research interest worldwide owing to their ultra-high solar-to-elec. power conversion efficiency and low fabrication costs, but their poor intrinsic stability issues still constitute the main obstacles that hinder their rapid commercialization. Herein, we demonstrate that, by carefully designing the modifier’s mol. structure, a facile, highly reproducible and scalable surface modification strategy can effectively enhance both the stability and efficiency of inverted PSCs. The most efficient modifier (2-acetylpyridine) can not only passivate the surface traps of the perovskite film but also enhance its stability against moisture by forming a hydrophobic capping layer on top. Accordingly, the efficiency of the inverted PSC has been improved from 16.75% to 20.05% for the best-performing one, which is, to our knowledge, among the highest values for inverted MA-free PSCs. More encouragingly, the stability of the modified devices can also be largely enhanced: the devices retained 95%, 90%, and 91% of their initial efficiencies after storage in the dark in ambient air for 2000 h, 85°C thermal aging for 500 h in the dark, and light soaking at 45°C for 500 h, resp. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Some scientific research about 1122-54-9

The chemical industry reduces the impact on the environment during synthesis 1122-54-9, I believe this compound will play a more active role in future production and life.

Application of 1122-54-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1122-54-9, name is 4-Acetylpyridine, molecular formula is C7H7NO, molecular weight is 121.14, as common compound, the synthetic route is as follows.

To a mixture of NaH (6.6 g, 165.2 mmol, 60%in mineral oil) in toluene (120 mL) was added dimethyl carbonate (11.2 g, 123.9 mmol) in toluene (40 mL) . Then 1- (pyridin-4-yl) ethanone (5.0 g, 41.3 mmol, 5) in toluene (40 mL) was added dropwise under N 2. The reaction mixture was stirred at 105 for 12 hours. After cooled to RT, the reaction was quenched with 200 mL (water) and HOAc (20 mL) and the mixture was stirred at RT for 20 minutes. Then the mixture was extracted with EtOAc (300 mL*3) . The combined organic layer was dried over Na 2SO 4, filtered and concentrated. The residue was purified by Prep-HPLC (water/acetonitrile = 10%to 90%) to give the title product (3.89 g, 53%, 6) as a brown solid. LC-MS: Rt = 1.20 min, [M+H] + = 180.

The chemical industry reduces the impact on the environment during synthesis 1122-54-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SHANGHAI CHANGCHENGYIYAOKEJI COMPANY LIMITED; XU, Mingyan; (0 pag.)WO2020/1475; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 4-Acetylpyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1122-54-9, 4-Acetylpyridine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 1122-54-9, Adding some certain compound to certain chemical reactions, such as: 1122-54-9, name is 4-Acetylpyridine,molecular formula is C7H7NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1122-54-9.

Preparation of 4-Bromoacetylpyridine, HBr saltHBrBromine (24 g, 150 mmol) in 4 mL of 45% HBr was added drop wise under vigorous stirring to a solution at 70C of 4-acetyl-pyridine (18 g, 148 mmol) in acetic acid containing 45% of HBr (165 mL). The vigorously stirred mixture was kept at 700C for 3h. The mixture was cooled and the precipitate collected by filtration and washed with petroleum ether(40-65C)/methanol (1/1, 100 mL) to give 35.8 g of a white crystals of (85%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1122-54-9, 4-Acetylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AB SCIENCE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); INSTITUT CURIE; WO2006/106437; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extracurricular laboratory: Synthetic route of 4-Acetylpyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1122-54-9, 4-Acetylpyridine, other downstream synthetic routes, hurry up and to see.

Application of 1122-54-9, Adding some certain compound to certain chemical reactions, such as: 1122-54-9, name is 4-Acetylpyridine,molecular formula is C7H7NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1122-54-9.

4-Bromoacetyl-pyridine, HBr salt; Dibromine (17.2g, 108 mmol) was added dropwise to a cold (0C) solution of 4-acetyl- pyridine (12 g, 99 mmol) in acetic acid containing 33% of HBr (165 mL) under vigourous stirring. The vigorously stirred mixture was warmed to 40C for 2h and then to 75C. After 2h at 75C, the mixture was cooled and diluted with ether (400 mL) to precipitate the product. which was recovered by filtration and washed with ether and acetone to give white crystals (100%). This material may be recrystallised from methanol and ether.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1122-54-9, 4-Acetylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AB SCIENCE; WO2005/73225; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem