Category: 1122-54-9

Synthetic Route of 1122-54-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1122-54-9, Name is 4-Acetylpyridine, SMILES is C1=C(C(=O)C)C=CN=C1, belongs to pyridine-derivatives compound. In a article, author is Deng, Peipei, introduce new discover of the category.

A rapid on-off-on mitochondria-targeted phosphorescent probe for selective and consecutive detection of Cu2+ and cysteine in live cells and zebrafish

The detection of mitochondrial Cu2+ and cysteine is very important for investigating cellular functions or dysfunctions. In this study, we designed a novel cyclometalated iridium(iii) luminescence chemosensor Ir bearing a bidentate chelating pyrazolyl-pyridine ligand as a copper-specific receptor. The biocompatible and photostable Ir complex exhibited not only mitochondria-targeting properties but also an on-off-on type phosphorescence change for the reversible dual detection of Cu2+ and cysteine. Ir had a highly sensitive (detection limit = 20 nM) and selective sensor performance for Cu2+ in aqueous solution due to the formation of a non-phosphorescent Ir-Cu(ii) ensemble through 1 : 1 binding. According to the displacement approach, Ir was released from the Ir-Cu(ii) ensemble accompanied with turn-on phosphorescence in the presence of 0-10 mu M cysteine, with a low detection limit of 54 nM. This on-off-on process could be accomplished within 30 s and repeated at least five times without significant loss of signal strength. Moreover, benefiting from its good permeability, low cytotoxicity, high efficiency, and anti-interference properties, Ir was found to be suitable for imaging and detecting mitochondrial Cu2+ and cysteine in living cells and zebrafish.

Synthetic Route of 1122-54-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 1122-54-9 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Tripathi, Suparna, once mentioned the application of 1122-54-9, Name is 4-Acetylpyridine, molecular formula is C7H7NO, molecular weight is 121.14, MDL number is MFCD00006433, category is pyridine-derivatives. Now introduce a scientific discovery about this category, Product Details of 1122-54-9.

Supramolecular association and quantification of intermolecular interactions of 4 ‘-functionalized 2,2 ‘:6 ‘,2 ”-terpyridines: Experimental observation and theoretical studies

Three versatile 4′-substituted 2,2′:6′,2 ”-terpyridine compounds (1-3) having different substitutions (4-ethoxyphenyl, 4-methoxyphenyl and pyridyl) at 4’-position of the central pyridine ring have been synthesized and structurally characterized. Three representative crystal structures have been determined through single crystal X-ray diffraction analysis. X-ray crystallography revels that the structures are stabilized through C-H center dot center dot center dot pi at and pi-pi stacking interactions. In the solid-state, the supramolecular assemblies of the title compounds have been explored in detail. Compounds (1) and (3) exhibits both C-H center dot center dot center dot pi and pi-pi interactions in building supramolecular assemblies whereas compound (2) exhibit pi-pi interaction only. All the intermolecular interactions that are involved within the structures are quantified through Hirshfeld surface analyses. The weak noncovalent interactions that played significant role in building supramolecular assemblies are further characterized by Bader’s theory of ‘atoms-in-molecules’ (AIM). Finally, the supramolecular networks are characterized by theoretical ‘Noncovalent Interaction’ (NCI) plot index. The supramolecular solid-state frameworks of three 4′-functionalized 2,2′:6′,2 ”-terpyridine derivatives have been quantified which are further characterized theoretically by the Bader’s theory of ‘atoms-inmolecules'(AIM) and ‘noncovalent interaction’ (NCI) plot index. (C) 2020 Published by Elsevier B.V.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 1122-54-9, Product Details of 1122-54-9.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Related Products of 1122-54-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1122-54-9, name is 4-Acetylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a 9 sodium hydride (60% in 10 paraffin oil) (1.98g, 0.049mol), 10mL of 11 Dimethyl formamide was added dropwise at 5C under nitrogen atmosphere. To this mixture, 12 4-acetylpyridine (3.0g, 0.024mmol) was added dropwise and stirred for 30min at ambient temperature. Then 13 diethyl oxalate (4.03mL, 0.029mol) was added slowly and the reaction mixture was again stirred for 3h at room temperature. The completion of the reaction was monitored by TLC and quenched with crushed ice. Then the reaction mixture was extracted with ethyl acetate (1x100mL), washed with water (100mL) and brine solution (100mL). The organic layer was separated, dried over anhydrous sodium sulfate and evaporation of solvent affords the expected intermediate 14 1. (White solid, Yield 78%). 1H NMR (300MHz, CDCl3) delta 8.78 (d, J=5.5Hz, 2H), 7.85 (d, J=5.5Hz, 2H), 4.42 (q, J=14.0, 7.1Hz, 2H), 1.42 (t, J=7.0Hz, 3H). 13C NMR (75MHz, CDCl3) delta 192.89, 173.26, 165.10, 150.57, 137.70, 122.79, 61.75, 29.62, 14.15.

According to the analysis of related databases, 1122-54-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Madhu; Sivakumar; Journal of Photochemistry and Photobiology A: Chemistry; vol. 371; (2019); p. 341 – 348;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1122-54-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1122-54-9, name is 4-Acetylpyridine, molecular formula is C7H7NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-acetylpyridine (1.00 mL, 9.04 mmol) was added to a solution of HBr (47 % in 0, 4.56 mL, 27.12 mmol) in AcOH (20 mL) at 25 C. Bromine (1.59 g, 0.51 mL, 9.94 mmol) was added dropwise to the solution, then a white precipitate appeared slowly. The mixture was stirred for 20 h. Diethyl ether (20 mL) was added, the solid was filtered and washed with diethyl ether (2 x 5 mL). After drying under vacuum, 4-(2-bromoacetyl)pyridin-l-ium bromide was obtained as an off-white solid (2.529 g) which was used without further purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1122-54-9, 4-Acetylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MASARYKOVA UNIVERZITA; PARUCH, Kamil; CARBAIN, Benoit; HAVEL, Stepan; DAMBORSKY, Jiri; BREZOVSKY, Jan; DANIEL, Lukas; SISAKOVA, Alexandra; NIKULENKOV, Fedor; KREJCI, Lumir; (190 pag.)WO2019/201865; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1122-54-9, name is 4-Acetylpyridine. This compound has unique chemical properties. The synthetic route is as follows. 1122-54-9

[00234] To a solution of l-(pyridin-4-yl)ethanone (1.0 g, 8.25 mmol) in HOAc (60 mL) under ice bath was added aqueous HBr (1 mL, 48%) and Br2 (1.45 g, 9.1 mmol) in HOAc (20 mL). The mixture was stirred at rt for 4 h during which time a precipitate formed. Filtration of the solid provided 2-bromo-l-(pyridin-4-yl)ethanone hydrobromide (0.72 g, 3.6 mmol) as a yellow solid. LC/MS [M+H]+ = 200.1.

Statistics shows that 1122-54-9 is playing an increasingly important role. we look forward to future research findings about 4-Acetylpyridine.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; NEWCOM, Jason, S.; SPEAR, Kerry, L.; WO2015/88564; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1122-54-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1122-54-9 as follows.

4-Bromoacetyl-pyridine, HBr salt; Dibromine (17.2g, 108 mmol) was added dropwise to a cold (0C) solution of 4-acetyl- pyridine (12 g, 99 mmol) in acetic acid containing 33% of HBr (165 mL) under vigourous stirring. The vigorously stirred mixture was warmed to 40C for 2h and then to 75C. After 2h at 75C, the mixture was cooled and diluted with ether (400 mL) to precipitate the product. which was recovered by filtration and washed with ether and acetone to give white crystals (100%). This material may be recrystallised from methanol and ether.

The chemical industry reduces the impact on the environment during synthesis 1122-54-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; AB SCIENCE; WO2005/73225; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1122-54-9, A common compound: 1122-54-9, name is 4-Acetylpyridine,molecular formula is C7H7NO, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Preparation of 4-Bromoacetylpyridine, HBr saltHBrBromine (24 g, 150 mmol) in 4 mL of 45% HBr was added drop wise under vigorous stirring to a solution at 70C of 4-acetyl-pyridine (18 g, 148 mmol) in acetic acid containing 45% of HBr (165 mL). The vigorously stirred mixture was kept at 700C for 3h. The mixture was cooled and the precipitate collected by filtration and washed with petroleum ether(40-65C)/methanol (1/1, 100 mL) to give 35.8 g of a white crystals of (85%).

With the rapid development of chemical substances, we look forward to future research findings about 1122-54-9.

Reference:
Patent; AB SCIENCE; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE(CNRS); INSTITUT CURIE; WO2006/106437; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem