Category: 1122-54-9

In 2022,Ju, Zhao-Yang; Song, Li-Na; Chong, Ming-Ben; Cheng, Dang-Guo; Hou, Yang; Zhang, Xi-Ming; Zhang, Qing-Hua; Ren, Lan-Hui published an article in Journal of Organic Chemistry. The title of the article was 《Selective Aerobic Oxidation of Csp3-H Bonds Catalyzed by Yeast-Derived Nitrogen, Phosphorus, and Oxygen Codoped Carbon Materials》.COA of Formula: C7H7NO The author mentioned the following in the article:

Nitrogen, phosphorus and oxygen codoped carbon catalysts were successfully synthesized using dried yeast powder as pyrolysis precursor. The yeast-derived heteroatom-doped carbon (yeast@C) catalysts exhibited outstanding performance in the oxidation of Csp3-H bonds to ketones and esters giving excellent products yields (up to 98% yield) without organic solvents at low O2 pressure (0.1 MPa). The catalytic oxidation protocol exhibited broad range of substrates (38 examples) with good functional group tolerance, excellent regioselectivity and synthetic utility. The yeast-derived heteroatom-doped carbon catalysts showed good reusability and stability after recycle six times without any significant loss of activity. Exptl. results and DFT calculations proved the important role of N-oxide (N+-O-) on the surface of yeast@C and a reasonable carbon radical mechanism. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fujita, Shu; Yamaguchi, Sho; Yamasaki, Jun; Nakajima, Kiyotaka; Yamazoe, Seiji; Mizugaki, Tomoo; Mitsudome, Takato published an article in 2021. The article was titled 《Ni2P Nanoalloy as an Air-Stable and Versatile Hydrogenation Catalyst in Water: P-Alloying Strategy for Designing Smart Catalysts》, and you may find the article in Chemistry – A European Journal.Safety of 4-Acetylpyridine The information in the text is summarized as follows:

Non-noble metal-based hydrogenation catalysts have limited practical applications because they exhibit low activity, require harsh reaction conditions, and are unstable in air. To overcome these limitations, herein the alloying of non-noble metal nanoparticles with phosphorus as a promising strategy for developing smart catalysts that exhibit both excellent activity and air stability was proposed. A novel nickel phosphide nanoalloy (nano-Ni2P) with coordinatively unsaturated Ni active sites was synthesized. Unlike conventional air-unstable non-noble metal catalysts, nano-Ni2P retained its metallic nature in air, and exhibited a high activity for the hydrogenation of various substrates with polar functional groups, such as aldehydes, ketones, nitriles, and nitroarenes to the desired products in excellent yields in water. Furthermore, the used nano-Ni2P catalyst was easy to handle in air and could be reused without pretreatment, providing a simple and clean catalyst system for general hydrogenation reactions. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Heterocycles 45.Synthesis, characterization and biological evaluation of 3-indolyl-1-pyridyl-2-propenones as anticancer agents》 was published in Farmacia (Bucharest, Romania) in 2020. These research results belong to Kamga, Justin; Leonte, Denisa; Ambassa, Pantaleon; Mbaveng, Armelle T.; Fotso, Ghislain W.; Coman, Fana-Maria; Ngadjui, Bonaventure T.; Kuete, Victor; Zaharia, Valentin; Ngameni, Bathelemy. Category: pyridine-derivatives The article mentions the following:

A series of seven indolyl pyridyl propenones I [R = H, Me, Et, etc.; Ar = 3-pyridyl, 4-pyridyl] were synthesized via Claisen-Schmidt condensation with 68.8-91.8% yields. All the synthesized compounds I were purified and characterized by m.ps., IR, 1H NMR, 13C NMR and HRMS. The cytotoxicity of the synthesized indolyl pyridyl propenones I and doxorubicin, used as pos. control, was determined in a panel of nine human cancer cell lines including both sensitive and drug-resistant phenotypes, as well as in normal AML12 hepatocytes. Compounds I [R = Et, allyl; Ar = 4-pyridyl] and [R = Me; Ar = 3-pyridyl] displayed half maximal inhibitory concentration (IC50) values below 100μM in all tested cancer cell lines meanwhile, other compounds displayed selective activities. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Zn(II) and Cd(II) monomer, dimer and polymer compounds coordinated by benzoic acid and 4-acetylpyridine: Synthesis and crystal structures》 was written by Moreno-Gomez, Laura; Sanchez-Ferez, Francisco; Calvet, Teresa; Font-Bardia, Merce; Pons, Josefina. SDS of cas: 1122-54-9This research focused onzinc cadmium benzoate acetylpyridine complex preparation fluorescence; crystal structure zinc cadmium benzoate acetylpyridine. The article conveys some information:

Reaction of MO (MO = Metal oxide, M = Zn(II) or Cd(II)) with benzoic acid (HBz) in H2O/MeOH mixture as solvent yields two benzoate compounds: [Zn(μ-Bz)2]n (1) and [Cd(Bz)2(H2O)3] (2). In addition, the reaction between M(MeCO2)2 (M = Zn(II) or Cd(II)) with HBz and 4-acetylpyridine (4-Acpy) in a 1:2:4 M ratio and in MeOH solution, leads to the formation of [Zn(μ-Bz)2(4-Acpy)]2 (3) and [Cd(μ-Bz)2(4-Acpy)2]2 (4). These four compounds have been fully characterized by anal. and spectroscopic techniques. Besides, their crystal structures have been elucidated revealing a 1D coordination polymer (1), a monomer (2), a paddle-wheel (3) and a dimer (4). In 1, the Zn(II) ion is four-coordinated in a tetrahedral geometry while in 3 is penta-coordinated in a square-pyramidal geometry. By contrast, compounds 2 and 4 exhibit seven-coordinated Cd(II) ions in a pentagonal-bipyramidal geometry. In these set of compounds, the benzoate ligand presents different coordination modes such as bidentate bridged (μ2-η1:η1) (1 and 3), chelate (μ1-η2) (2) and both bridged and chelate (μ2-η2:η1) (4). Besides, their extended structures have been analyzed. Finally, the UV-Vis and fluorescence spectra of all the compounds have been recorded as well as their quantum yields calculated4-Acetylpyridine(cas: 1122-54-9SDS of cas: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.SDS of cas: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 1122-54-9In 2020 ,《Synthesis of selective bioactive pyridylpyridones: in silico studies and biological evaluations》 appeared in Asian Journal of Chemistry. The author of the article were Ramasamy, Suresh; Ponnuchamy, Singanan; Ponnusamy, Sivakumar. The article conveys some information:

Twenty three substituted pyridylpyridones I (X = CH, N; Y = N, CH; R = H, 2,5-F2, 4-Cl, 4-OMe, etc.) were designed and performed for mol. docking studies against α-amylase enzyme. Exptl. biol. applications were studied for the top three hit compounds (X = N, Y = CH, R = 2-Cl; X = CH, Y = N, R = H; X = CH, Y = N, R = 2,5-F2). The DFT calculations were executed for the hit compounds In addition, mol. electrostatic potential mapping was also executed for addnl. support. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 1122-54-9In 2021 ,《3H-Pyrazolo[4,3-f]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo》 appeared in Journal of Medicinal Chemistry. The author of the article were Dayal, Neetu; Reznickova, Eva; Hernandez, Delmis E.; Perina, Miroslav; Torregrosa-Allen, Sandra; Elzey, Bennett D.; Skerlova, Jana; Ajani, Haresh; Djukic, Stefan; Vojackova, Veronika; Lepsik, Martin; Rezacova, Pavlina; Krystof, Vladimir; Jorda, Radek; Sintim, Herman O.. The article conveys some information:

Herein, various 3H-pyrazolo[4,3-f]quinoline-containing compounds e.g., I were rapidly assembled via the Doebner-Povarov multicomponent reaction from the readily available 5-aminoindazoles, ketones and aldehydes in good yields. The most active compounds potently inhibit the recombinant FLT3 kinase and its mutant forms with nanomolar IC50 values. Docking studies with the FLT3 kinase showed a type I binding mode, where the 3H-pyrazolo group interacts with Cys694 in the hinge region. The compounds blocked the proliferation of AML cell lines harboring oncogenic FLT3-ITD mutations with remarkable IC50 values, which were comparable to the approved FLT3 inhibitor quizartinib. The compounds also inhibited the growth of leukemia in a mouse-disseminated AML model, and hence, the novel 3H-pyrazolo[4,3-f]quinoline-containing kinase inhibitors are potential lead compounds to develop into anticancer agents, especially for kinase-driven cancers. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Youssef, Heba; Sedykh, Alexander E.; Becker, Jonathan; Schafer, Thomas; Taydakov, Ilya V.; Li, Huanrong R.; Mueller-Buschbaum, Klaus published an article in 2021. The article was titled 《Variable Luminescence and Chromaticity of Homoleptic Frameworks of the Lanthanides together with Pyridylpyrazolates》, and you may find the article in Chemistry – A European Journal.Related Products of 1122-54-9 The information in the text is summarized as follows:

Homoleptic, 3D coordination polymers of the formula 33∞[Ln(3-PyPz)3] and 3∞[Ln(4-PyPz)3], (3-PyPz)- = 3-(3-pyridyl)pyrazolate anion, (4-PyPz)- = 3-(4-pyridyl)pyrazolate anion, both C8H6N3-, Ln = Sm, Eu, Gd, Tb, Dy, were obtained as highly luminescent frameworks by reaction of the lanthanide metals (Ln) with the aromatic heterocyclic amine ligands 3-PyPzH and 4-PyPzH. The compounds form 2 isotypic series of 3D coordination polymers and exhibit fair thermal stability up to 360°. The luminescence properties of all 10 compounds were determined in the solid state, with an antenna effect through ligand-metal energy transfer leading to high efficiency of the luminescence displayed by good quantum yields of up to 74%. The emission is mainly based on ion-specific lanthanide-dependent intra 4f-4f transitions for Tb3+: green, Dy3+: yellow, Sm3+: orange-red, Eu3+: red. For the Gd3+-containing compounds, the yellow emission of ligand triplet-based phosphorescence is observed at room temperature and 77 K. Codoping of the Gd-containing frameworks with Eu3+ and Tb3+ allow further shifting of the chromaticity towards white light emission. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis and biological evaluation of 4-aryl-5-aminoalkyl-thiazole-2-amines derivatives as ROCK II inhibitors》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Ma, Shuchao; Wang, Linan; Ouyang, Ben; Fan, Meixia; Qi, Junhui; Yao, Lei. Synthetic Route of C7H7NO The article mentions the following:

A series of 4-aryl-5-aminoalkyl-thiazole-2-amines I (n = 0, 1, 2; X = N, CH; Y = N, CH; R = N,N-dimethylcarbamoyl, morpholin-4-yl, 4-methylpiperazin-1-yl, etc.; R1 = pyridin-4-yl, pyridin-3-yl, 2,3-dihydro-1,4-benzodioxin-2-yl) was designed and synthesized, and their inhibitory activity on ROCK II was screened by ELISA (ELISA). The results showed that 4-aryl-5-aminomethyl-thiazole-2-amines derivatives I had certain ROCK II inhibitory activities. Compound I (n = 1; X = N; Y = CH; R = morpholin-4-yl; R1 = 2,3-dihydro-1,4-benzodioxin-2-yl) showed ROCK II inhibitory activity with IC50 value of 20 nM.4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand》 were Tanaka, Kouichi; Miki, Takashi; Murata, Kunihiko; Yamaguchi, Ayumi; Kayaki, Yoshihito; Kuwata, Shigeki; Ikariya, Takao; Watanabe, Masahito. And the article was published in Journal of Organic Chemistry in 2019. HPLC of Formula: 1122-54-9 The author mentioned the following in the article:

Cp*Ir complexes bearing a 2-picolinamide moiety serve as effective catalysts for the direct reductive amination of ketonic compounds to give primary amines under transfer hydrogenation conditions using ammonium formate as both the nitrogen and hydrogen source. The clean and operationally simple transformation proceeds with a substrate to catalyst molar ratio (S/C) of up to 20,000 at relatively low temperature and exhibits excellent chemoselectivity toward primary amines. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dai, Zengjin; Pan, Ying-Min; Wang, Shou-Guo; Zhang, Xumu; Yin, Qin published an article in 2021. The article was titled 《Direct reductive amination of ketones with ammonium salt catalysed by Cp*Ir(III) complexes bearing an amidato ligand》, and you may find the article in Organic & Biomolecular Chemistry.SDS of cas: 1122-54-9 The information in the text is summarized as follows:

A series of half-sandwich Ir(III) complexes bearing an amidato bidentate ligand were conveniently synthesized and applied to the catalytic Leuckart-Wallach reaction to produce racemic α-chiral primary amines. With 0.1 mol% of complex I, a broad range of ketones, including aryl ketones, dialkyl ketones, cyclic ketones, α-keto acids, α-keto esters and diketones, could be transformed to their corresponding primary amines with moderate to excellent yields (40%-95%). Asym. transformation was also attempted with chiral Ir complexes, and 16% ee of the desired primary amine was obtained. Despite the unsatisfactory enantio-control achieved so far, the current exploration might stimulate more efforts towards the discovery of better chiral catalysts for this challenging but important transformation. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9SDS of cas: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. SDS of cas: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem