Category: 1122-54-9

Application of 1122-54-9In 2021 ,《Three-Component Reaction of 3,3-Difluorocyclopropenes, s-Tetrazines, and (benzo) Pyridines》 appeared in Journal of Organic Chemistry. The author of the article were Nechaev, Ilya V.; Cherkaev, Georgij V.; Boev, Nikolay V.; Solyev, Pavel N.. The article conveys some information:

A new three-component reaction leading to 1-α-(pyridyl-2-[1,2,4]triazolyl)-2-alkyl-ethanones has been discovered while studying the reactivity of monosubstituted 3,3-difluorocyclopropenes in an inverse electronic demand Diels-Alder (IEDDA) cycloaddition-cycloreversion sequence with s-tetrazines. The reaction involving the above-mentioned reactants and (benzo)pyridine as a third component results in a complex transformation proceeding in mild conditions in a stoichiometric ratio of reactants and has high functional group tolerance (phenols, amides, ethers, carboxylic acids, ketones, and acrylic esters). As a result, simple pyridines are selectively functionalized at the α-position in good isolated yields. The reaction mechanism includes a rare azaphilic [4 + 2]-cycloaddition step between s-tetrazine and intermediate 1-hydroxyindolizine, suggested after byproduct identification and tracked with a deuterium label. To date, it is only the third known example of skewed azaphilic cycloaddition of tetrazine. The reaction is truly three-component and cannot be effectively performed stepwise. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C7H7NOIn 2022 ,《Unique Pseudo-Cross-Conjugated Mesomeric Betaines via an Iodate-Promoted Reaction of 3,3-Difluorocyclopropenes, Pyridines, and Anilines》 appeared in Journal of Organic Chemistry. The author of the article were Nechaev, Ilya V.; Cherkaev, Georgij V.; Sheremetev, Aleksei B.. The article conveys some information:

A simple method for the synthesis of (E)-3-arylimino-3H-indolizin-4-ium-1-olates by an iodate-promoted multicomponent reaction between 3,3-difluorocyclopropenes, pyridines, and anilines was discovered. The reaction products belong to a limited and underexplored class of pseudo-cross-conjugated heterocyclic mesomeric betaines isoconjugated with odd nonalternant hydrocarbon anions, whose properties were studied. Reversible nucleophilic addition at the C5 position was revealed as their main chem. feature, which had an access to novel fully conjugated 1,5-dioxo-3-arylamino-1,5-dihydroindolizine and tetracyclic 4-oxo-4,6-dihydrocyclopenta[4,5]pyrimido[2,1,6-cd]indolizine ring systems in one step. Both the synthesis of betaines and their transformations demonstrate a high level of functional group compatibility, allowing the ready preparation of a number of structurally attractive compounds for materials or medicinal chem. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《(2-Fluoroallyl)boration of Ketones with (2-Fluoroallyl)boronates》 was published in Journal of Organic Chemistry in 2020. These research results belong to Novikov, Maxim A.; Bobrova, Angelina Yu.; Mezentsev, Igor A.; Medvedev, Michael G.; Tomilov, Yury V.. Category: pyridine-derivatives The article mentions the following:

Efficient routes toward activation of gem-chlorofluorocyclopropane-derived (2-fluoroallyl)boronates for allylboration of various ketones including functionalized and low-reactive ones were developed. Increasing the B electrophilicity by the transformation of a boronate moiety into a borinic ester with BuLi/trifluoroacetic anhydride (TFAA) makes (2-fluoroallyl)boration of acetyl arenes/hetarenes and aliphatic ketones possible with high diastereoselectivity. For low-reactive or sterically hindered ketones (e.g., benzophenone, adamantanone), CuF-based catalysts were developed: (NHC)CuF·HF and (NHC)CuOTf in the presence of an excess of KHF2 (NHC = IPr, SIPr, IPrCl). The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-AcetylpyridineIn 2021 ,《Manganese-catalyzed homogeneous hydrogenation of ketones and conjugate reduction of α,β-unsaturated carboxylic acid derivatives: A chemoselective, robust, and phosphine-free in situ-protocol》 was published in Applied Catalysis, A: General. The article was written by Vielhaber, Thomas; Topf, Christoph. The article contains the following contents:

A user-friendly and glove-box-free catalytic protocol for the manganese-catalyzed hydrogenation of ketones RC(O)R1 (R = Ph, 2-chlorophenyl, pyridin-3-yl, etc.; R1 = Me, Et, Ph, etc.; RR1 = -(CH2)5-, -(CH2)4-), 3-methylcyclohexan-1-one, isophorone and 1-indanone and conjugated C=C-bonds of esters and nitriles R2C(R3)=C(R4)R5 (R2 = Ph, 4-bromophenyl, 3-cyanophenyl, etc.; R3 = H, Ph; R4 = methoxycarbonyl, (prop-2-en-1-yloxy)carbonyl, Ph, etc.; R5 = H, ethoxycarbonyl, CN) was communicated. The resp. catalyst is readily assembled in situ from the privileged [Mn(CO)5Br] precursor and cheap 2-picolylamine. The catalytic transformations were performed in the presence of t-BuOK whereby the corresponding hydrogenation products were obtained in good to excellent yields. The described system offers a brisk and atom-efficient access to both secondary alcs. (RCH(OH)R1, cyclohexanol, 3,5,5-trimethylcyclohex-2-en-1-ol and 1-indanol) and saturated esters R2(R3)CHCH(R4)R5 avoiding the use of oxygen-sensitive and expensive phosphine-based ligands. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Schiltz, Pauline; Casaretto, Nicolas; Auffrant, Audrey; Gosmini, Corinne published an article in Chemistry – A European Journal. The title of the article was 《Cobalt Complexes Supported by Phosphinoquinoline Ligands for the Catalyzed Hydrosilylation of Carbonyl Compounds》.Related Products of 1122-54-9 The author mentioned the following in the article:

Alkoxysilanes ArCHMeOSiHPh2 were prepared by hydrosilylation of acetophenones ArCOMe with SiH2Ph2 catalyzed by cobalt(II) 8-phosphinoquinoline (8-R2Pquin, L; R = iPr, Ph) complexes [(8-R2Pquin)CoBr2] and [(8-R2Pquin)2CoBr][PF6]. P,N phosphinoquinoline based ligands differing by the nature of the phosphorus substituent (iPr, Ph) were employed to synthesize a series of cobalt(II) complexes ([LCoBr2], [L2CoBr](PF6) and [L’2CoBr](PF6)). The complex [(8-Ph2Pquin)2CoBr][PF6] was obtained in high yield and characterized among others by X-ray anal. and elemental anal. Complex [(8-iPr2Pquin)2CoBr][PF6] showed a very good catalytic activity for the hydrosilylation of various ketones. The catalysis proceeds at a low catalytic loading (1 mol %) with only 1 equiv of Ph2SiH2 in mild conditions and was efficient with aliphatic or aromatic ketones giving moderate to excellent yields of the corresponding silylated ether. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Patel, Paresh N.; Desai, Dipen H.; Patel, Nilam C.; Deshmukh, Amar G. published an article in Journal of Molecular Structure. The title of the article was 《Efficient multicomponent processes for synthesis of novel poly-nuclear hetero aryl substituted terpyridine scaffolds: Single crystal XRD study》.Synthetic Route of C7H7NO The author mentioned the following in the article:

Authors studied the synthesis of novel terpyridine scaffolds from poly-nuclear and hetero-aryl aldehydes by the multicomponent condensation reactions with various acetyl pyridine derivatives in the presence of ammonium hydroxide. Comparative studies of two different processes catalyzed by potassium hydroxide and pyrrolidine have been performed and presented in this report. The structures of all the newly prepared terpyridine mols. have been well established by preforming various spectral anal. and single crystal XRD studies for selected mols. This approach addressed some structural miscellany concerns currently facing in photo-luminescent chem., and the derived hybrid pyridines could be used as suitable precursors for the synthesis of related photo-luminescent systems. The prepared scaffolds as such and their d-block or f-block metal complexes and coordination polymers may provide an efficient candidate for photo-luminescent chem. The results came from multiple reactions, including the reaction of 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Mahato, Shreya; Rawal, Parveen; Devadkar, Ajitrao Kisan; Joshi, Mayank; Roy Choudhury, Angshuman; Biswas, Bhaskar; Gupta, Puneet; Panda, Tarun K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Hydroboration and reductive amination of ketones and aldehydes with HBpin by a bench stable Pd(II)-catalyst》.Formula: C7H7NO The author mentioned the following in the article:

A palladium(II) complex [(κ4-{1,2-C6H4(N:CHC6H4O2)2})Pd] (1) supported by a dianionic salen ligand [1,2-C6H4(NCH-C6H4O)2]2- (L) was synthesized and used as a mol. pre-catalyst in the hydroboration of aldehydes and ketones. The mol. structure of Pd(II) complex 1 was established by single-crystal x-ray diffraction anal. Complex 1 was tested as a competent pre-catalyst in the hydroboration of aldehydes and ketones with pinacolborane (HBpin) to produce corresponding boronate esters in excellent yields at ambient temperature under solvent-free conditions. Further, the complex 1 proved to be a competent catalyst in the reductive amination of aldehydes with HBpin and primary amines under mild and solvent-free conditions to afford a high yield (up to 97%) of corresponding secondary amines. Both protocols provided high conversion, superior selectivity and broad substrate scope, from electron-withdrawing to electron-donating and heterocyclic substitutions. A computational study based on d. functional theory (DFT) revealed a reaction mechanism for Pd-catalyzed hydroboration of carbonyl species in the presence of HBpin. The protocols also uncovered the dual role of HBpin in achieving the hydroboration reaction. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C7H7NOIn 2020 ,《Copper-catalyzed formal [1 + 2 + 2]-annulation of alkyne-tethered diazoacetates and pyridines: access to polycyclic indolizines》 appeared in Organic & Biomolecular Chemistry. The author of the article were Dong, Shanliang; Huang, Jingjing; Sha, Hongkai; Qiu, Lihua; Hu, Wenhao; Xu, Xinfang. The article conveys some information:

A copper-catalyzed formal [1 + 2 + 2] annulation of alkyne-tethered diazo compounds with pyridines afforded polycyclic fused indolizines in good yields under mild reaction conditions was reported. This method features the use of an inexpensive copper catalyst and readily available starting materials, broad substrate generality and operational simplicity. Notably, a variety of natural product derivatives were compatible under the current conditions, which showed significant potential of this method for the selective decoration and modification of analogous biomols. or pharmaceuticals. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9COA of Formula: C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.COA of Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Patel, P. N.; Desai, D. H.; Patel, N. C. published an article in Russian Journal of Organic Chemistry. The title of the article was 《Novel Terpyridine Derivatives of Benzothiazole and Copper(II) Complex: Synthesis and Spectral Studies》.Synthetic Route of C7H7NO The author mentioned the following in the article:

Novel terpyridine derivatives of benzothiazole were synthesized by simple multicomponent 1-pot reaction of benzothiazole-2-carbaldehyde, ammonium hydroxide, and isomeric acetyl pyridines with isolated yields of 92-98%. All the prepared derivatives were characterized by NMR, IR, and high-resolution mass spectra. A Cu(II) complex was prepared selectively from the terpyridine derivative obtained from 2-acetylpyridine and was characterized by single-crystal x-ray anal. UV-visible spectra were recorded for all the synthesized compounds In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis and anticancer properties of isocombretapyridines as potent colchicine binding site inhibitors》 was written by Shuai, Wen; Li, Xinnan; Li, Wenlong; Xu, Feijie; Lu, Lixue; Yao, Hong; Yang, Limei; Zhu, Huajian; Xu, Shengtao; Zhu, Zheying; Xu, Jinyi. HPLC of Formula: 1122-54-9 And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

A series of novel isocombretapyridines were designed and synthesized based on a lead compound isocombretastatin A-4 (isoCA-4) by replacing 3,4,5-trimethoxylphenyl with substituent pyridine nucleus. The MTT assay results showed that compound I possessed the most potent activities against all tested cell lines with IC50 values at nanomolar concentration ranges. Moreover, I inhibited tubulin polymerization at a micromolar level and also displayed potent anti-vascular activity in vitro. Further mechanistic studies were conducted to demonstrate that compound I could bind to the colchicine site of tubulin,and disrupte the cell microtubule networks, induce G2/M phase arrest, promote apoptosis and depolarize mitochondria of K562 cells in a dose-dependent manner. Notably, I exhibited more potent tumor growth inhibition activity with 68.7% tumor growth inhibition than that of isoCA-4 in H22 allograft mouse model without apparent toxicity. The present results suggested that compound I may serve as a promising potent microtubule-destabilizing agent candidate for the development of therapeutics to treat cancer. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem