Category: 1122-54-9

HPLC of Formula: 1122-54-9In 2022 ,《Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands》 appeared in Journal of Molecular Structure. The author of the article were Ould Lamara, Kamilia; Makhloufi-Chebli, Malika; Benazzouz-Touami, Amina; Terrachet-Bouaziz, Souhila; Robert, Anthony; Machado-Rodrigues, Carine; Behr, Jean-Bernard. The article conveys some information:

Heterocyclic chalcones I [X = O; R = C6H5, 4-MeOC6H4, 2-thienyl, etc.] were synthesized by reaction of 4-acetylpyridine with the corresponding aromatic aldehydes under Claisen Schmidt conditions. These chalcones I were used as starting material for the synthesis of oximes I [X = HON; R = 4-MeOC6H4, 4-ClC6H4, 2-thienyl, etc.] and II in the presence of hydroxylamine hydrochloride. The structures of the synthesized compounds I and II were confirmed by IR, 1H NMR, 13C NMR and ESI-MS, HRMS spectral analyses. All the synthesized compounds I and II were evaluated for their antioxidant activity by DPPH• method and their in-vitro antimicrobial activity by disk diffusion method against two Gram-neg. bacteria, one Gram-pos. bacteria and two fungal strains (C. albicans and A. niger). The results showed that the synthesized compounds I and II did not display significant antioxidant activity. However, I [X = O; R = 3-thienyl, C6H5, 4-O2NC6H4, 4-ClC6H4, 2,6-di-ClC6H3] showed excellent antibacterial activity better than the standard drug against the bacterial strain S. aureus (ATCC 25923). The two compounds I [X = O; R = (E)-styryl, C6H5] proved very active against the fungal strain A. niger (MIC= 7.81μg/ mL, 15.62μg/mL resp.) while the antifungal drug used as reference (Fluconazole) was inactive. Mol. docking and mol. dynamics results revealed that the synthesized compounds, I [X = HON; R = 4-MeOC6H4, (E)-styryl] and II were involved in a large number of favorable interactions with the active site residues of the acetylcholinesterase protein, which can stabilize the ligands in the active site and increase their affinities. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1122-54-9In 2022 ,《Alkyl/Glycosyl Sulfoxides as Radical Precursors and Their Use in the Synthesis of Pyridine Derivatives》 appeared in Angewandte Chemie, International Edition. The author of the article were Xie, Demeng; Wang, Yingwei; Zhang, Xia; Fu, Zhengyan; Niu, Dawen. The article conveys some information:

Here the use of simple and readily available alkyl sulfoxides as precursors to radicals and their application in the preparation of pyridine derivatives are reported. It was shown that alkyl sulfoxides, N-methoxy pyridinium salts and fluoride anions form electron donor-acceptor (EDA) complexes in solution, which, upon visible light irradiation, undergo a radical chain process to afford various pyridine derivatives smoothly. This reaction displays broad scope with respect to both sulfoxides and N-methoxy pyridinium salts. The synthetic versatility of sulfoxides as a handle in chem. adds to their power as radical precursors. Glycosyl sulfoxides are converted to the corresponding pyridyl C-glycosides with high stereoselectivities. Computational and exptl. studies provide insights into the reaction mechanism. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Recommanded Product: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Akishina, E. A.; Dikusar, E. A.; Stepin, S. G.; Alekseyev, R. S.; Bumagin, N. A.; Potkin, V. I. published an article in 2022. The article was titled 《Synthesis of 4-Acetyl- and 4-Benzoylpyridine Derivatives with 1,2-Azole Fragments》, and you may find the article in Russian Journal of General Chemistry.Safety of 4-Acetylpyridine The information in the text is summarized as follows:

A method for the synthesis of 5-arylisoxazole- and 4,5-dichloroisothiazole-3-carboxylic acids derivatives I (R1 = H, Me, Ph; R2 = H, Cl; R3 = Cl, Ph, 4-methylphenyl, 4-nitrophenyl; X = S, O) based on 4-acetyl- and 4-benzoylpyridine has been developed. Esters I and amides II were prepared by acylation of (pyridin-4-yl)methanols III (R4 = OH) and (pyridin-4-yl)methanamines III (R4 = NH2) with acid chlorides of substituted 1,2-azole-3-carboxylic acids IV in ether or methylene chloride in the presence of triethylamine. Quaternary ammonium salts V of synthesized pyridine derivatives were also obtained. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Safety of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Safety of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《2D and 3D Zn(II) coordination polymers based on 4′-(Thiophen-2-yl)-4,2′:6′,4”-terpyridine: Structures and features of sorption behavior》 was written by Zaguzin, Alexander S.; Mahmoudi, Ghodrat; Sukhikh, Taisia S.; Sakhapov, Ilyas F.; Zherebtsov, Dmitry A.; Zubkov, Fedor I.; Valchuk, Karina S.; Sokolov, Maxim N.; Fedin, Vladimir P.; Adonin, Sergey A.. Application of 1122-54-9This research focused onzinc terephthalate iodoterephthalate thiophenylterpyridine coordination polymer preparation gas adsorption; crystal structure zinc terephthalate iodoterephthalate thiophenylterpyridine coordination polymer. The article conveys some information:

Reactions of Zn(II) nitrate, 4′-(thiophen-2-yl)-4,2′:6′,4”-terpyridine (ThioTerPy) and terephthalic (bdc) or 2-iodoterephthalic (2-I-bdc) acids result in 2D coordination polymer [Zn2bdc(ThioTerPy)2(OH)2] (1) or 3D metal-organic framework [Zn(2-I-bdc)(ThioTerPy)] (2), resp. Both compounds were characterized by X-ray diffractometry. For 2, I2 absorption, as well as selectivity of sorption of different organic substrates from mixtures was studied. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Visible-Light-Induced ortho-Selective Migration on Pyridyl Ring: Trifluoromethylative Pyridylation of Unactivated Alkenes》 was written by Jeon, Jinwon; He, Yu-Tao; Shin, Sanghoon; Hong, Sungwoo. Category: pyridine-derivatives And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

The photocatalyzed ortho-selective migration on a pyridyl ring has been achieved for the site-selective trifluoromethylative pyridylation of unactivated alkenes. The overall process was initiated by the selective addition of a CF3 radical to the alkene moiety of N-(alkenyloxy)pyridinium salts I [X = O, Z = (CH2)3, R1 = H, 2-Me, 3-MeO2C, 4-Ph, etc., R2 = H, Me; X = O, Z = CH2, CH2CH2, (CH2)4, R1 = 4-MeO2C, R2 = H; X = NTs, Z = CH2, CH2CH2, R1 = H, 4-MeO2C, R2 = H; etc.] to provide a nucleophilic alkyl radical intermediate, which enabled an intramol. endo addition exclusively to the ortho-position of the pyridinium salt to afford the corresponding functionalized pyridines II. Both secondary and tertiary alkyl radicals were well-suited for addition to the C2-position of pyridinium salts to ultimately provide synthetically valuable C2-fluoroalkyl functionalized pyridines. Moreover, the method was successfully applied to the reaction with P-centered radicals. The utility of this transformation was further demonstrated by the late-stage functionalization of complex bioactive mols. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine derivatives lend themselves to many roles in the spirited field of supramolecular chemistry – whether as the ligand backbone of metal-organic polymers or presiding over the key electronic stations of nanodevices. In biochemistry, pyridine-containing cofactors are necessary nutrients on which our lives depend. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4-AcetylpyridineIn 2019 ,《Energy-efficient sonochemical approach for the preparation of nanohybrid composites from graphene oxide and metal-organic framework》 was published in Inorganic Chemistry Communications. The article was written by Tanhaei, Mahboobeh; Mahjoub, Ali Reza; Safarifard, Vahid. The article contains the following contents:

Two-fold interpenetration zinc-based metal-organic framework/graphene oxide (TMU-16-NH2/GO) nanohybrid materials were synthesized under a green, simple and large-scale sonochem. preparation method at room temperature and atm. pressure. The role of concentrations of graphene oxide on size and morphol. of nanostructures TMU-16-NH2/GO hybrid have been studied. The materials were characterized by SEM, powder x-ray diffraction (PXRD), FTIR spectroscopy and nitrogen adsorption. Both of the pure MOF and the nanohybrid MOF/GO composites exhibit microporous structure with a small number of mesopores. TMU-16-NH2 shows type IV isotherm with a H4 hysteresis loop, while the isotherm of TMU-16-NH2/GO appears to show normal Type II adsorption with a Type H3 hysteresis loop. The results obtained demonstrate this method to be applicable to the synthesis of other MOFs/GO nanohybrids and may possibly find various forthcoming industrial and technol. applications. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Reference of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Reference of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kurose, Ayako; Ishida, Yuto; Hirata, Goki; Nishikata, Takashi published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Direct α-Tertiary Alkylations of Ketones in a Combined Copper-Organocatalyst System》.Product Details of 1122-54-9 The article contains the following contents:

Herein, we report an efficient method for the tertiary alkylation of a ketone by using an α-bromocarbonyl compound as the tertiary alkyl source in a combined Cu-organocatalyst system. This dual catalyst system enables the addition of a tertiary alkyl radical to an enamine. Mechanistic studies revealed that the catalytically generated enamine is a key intermediate in the catalytic cycle. The developed method can be used to synthesize substituted 1,4-dicarbonyl compounds containing quaternary carbons bearing various alkyl chains. The experimental process involved the reaction of 4-Acetylpyridine(cas: 1122-54-9Product Details of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Product Details of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Design, synthesis, and evaluation of anticancer potential of some new benzopyran Schiff base derivatives》 was published in Indian Journal of Heterocyclic Chemistry in 2020. These research results belong to Kumar, Piyush; Rahman, Azizur Md.; Wal, Pranay; Singh, Kuldeep. Name: 4-Acetylpyridine The article mentions the following:

The present study was carried out to design, synthesize, and evaluate the anticancer activity of newly synthesized benzopyran Schiff bases I [R1 = Me, R2 = Ph, 4-ClC6H4, 2-pyridyl, etc.; R1 = R2 = Ph; R1R2C = adamantan-2-ylidene] on MCF-7 and MDA-MB-231 cell lines. Docking studies, in silico absorption, distribution, metabolism, elimination (ADME), and predicted toxicity studies have also been performed. Designed compounds I were synthesized by condensation of the substituted Trolox hydrazide with various ketones. All synthesized compounds I were tested on MCF-7 and MDA-MB-231 cell lines for anticancer activity. All compounds I, except for I (R1 = Me; R2 = 2-naphthyl) showed better docking scores than standard The majority of the compounds displayed good to potent anticancer activity on MCF-7 and MDA-MB-231 cell lines. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 4-AcetylpyridineIn 2019 ,《Synthesis, molecular structure and multiple biological activities of N-(3-methoxyphenyl)-3-(pyridin-4-yl)-1H-pyrazole-5-carboxamide》 appeared in Journal of Molecular Structure. The author of the article were Nithyabalaji, Rajendran; Krishnan, Hariharasubramanian; Sribalan, Rajendran. The article conveys some information:

A new mol. of pyridylpyrazole amide (PPA) was successfully synthesized. The UV-Vis spectral absorption and IR frequencies were theor. calculated and compared with observed results. The in vitro biol. applications like anti-inflammatory, antioxidant and antidiabetic activities were performed. The synthesized compound exhibited admirable anti-inflammatory activity and antidiabetic, worthy antioxidant activities than standards The interactions between enzyme-ligand were identified with α-amylase (1HNY.pdb) using the autodock tool. Further potential energy scan, fukui function and mol. electrostatic potential (MEP) were performed using DFT methods. Finally, in silico pharmacol. studies like ADME were implemented for PPA. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Recommanded Product: 4-Acetylpyridine) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivativesIn 2020 ,《Design, Drug-Likeness, Synthesis, Characterization, Antimicrobial Activity, Molecular Docking, and MTT Assessment of 1,3-Thiazolidin-4-one Bearing Piperonal and Pyrimidine Moieties》 was published in Russian Journal of Bioorganic Chemistry. The article was written by Mohammad Arshad. The article contains the following contents:

The recent study reported the designing of substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives and assessed computationally to calculate the bioactivity and physicochem. properties. The substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives represented the bioactivity score in the zone for an active drug mol. and were in compliance with the Lipinski Rule of five. Then the synthesis, characterization, and biol. screening as antimicrobial potential and percent viability of cells were carried out for the substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives The zone of inhibition and min. inhibitory concentration (MIC) findings portrayed that the compounds-(IV) and compound-(V) possessed better antimicrobial activity than the reference drug ciprofloxacin, while the significant antimicrobial potential was observed by other members of the series. The mol. docking studies were performed to assist the in vitro antimicrobial results and the findings exhibited that significant H-bonding in between the substituted 3-[4-(1,3-benzodioxol-5-yl)-6-(pyridin-2-yl)pyrimidin-2-yl]-2-(pyridin-2-yl)-1,3-thiazolidin-4-one derivatives and the residues of GlcN-6-P-synthase, like ASP 474 (I-IX), SER 316 (I-VI), ASN 522 (I-IX), TRP 313 (V) with good binding affinity ranging -7.7 to -6.8 kcal/mol. The compounds represented the less toxic effects to the HepG2 cells and the percent viability of the cells ranging from 93-98%, 73-78% and 70-76% up to 3.125, 50, 100 mmol/L resp. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem