Category: 1122-54-9

The author of 《Structure characterization and antitumor activity of palladium pseudo halide complexes with 4-acetylpyridine》 were El-bendary, Mohamed M.; Arshad, Muhammad N.; Asiri, Abdullah M.. And the article was published in Journal of Coordination Chemistry in 2019. Related Products of 1122-54-9 The author mentioned the following in the article:

The addition of an aqueous solution of palladium chloride to an aqueous acetonitrile solution of 4-acetylpyridine (4-Acpy) and KSCN or NaN3 produces new complexes, [Pd(SCN)2(4-Acpy)2] (1) and [Pd(N3)2(4-Acpy)2] (2), at ambient conditions. Complexes 1 and 2 were characterized by elemental anal., FTIR, and UV-Visible spectra. The structures of 1 and 2 were determined by single crystal x-ray diffraction. The coordination geometry around the palladium center is distorted square planar in 1 and 2 as the palladium is coordinated with two 4-acetylpyridine and two thiocyanates in 1 or two azide groups in 2. The discrete units of 1 and 2 extend along the a-axis creating a 1 D-chain via noncovalent hydrogen bonds. The extensive noncovalent hydrogen bonds extend the structure of 1 and 2 to 3-dimensional-networks. Using MTT assay, the cytotoxic activities of 1 and 2 were screened against two cancer cell lines, HePG-2 (liver cancer) and MCF-7 (breast cancer). The MTT assay revealed that the cytotoxic activity of 1 is stronger than 2 for HePG-2 and MCF-7. Antioxidant and anti-hemolytic activities of 1 and 2 were examined Also, the luminescence spectra in the solid state of 1 and 2 are discussed. In the experiment, the researchers used 4-Acetylpyridine(cas: 1122-54-9Related Products of 1122-54-9)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Related Products of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A Single-Crystal Open-Capsule Metal-Organic Framework》 were Wei, Yong-Sheng; Zhang, Mei; Kitta, Mitsunori; Liu, Zheng; Horike, Satoshi; Xu, Qiang. And the article was published in Journal of the American Chemical Society in 2019. Application In Synthesis of 4-Acetylpyridine The author mentioned the following in the article:

Micro-/nanocapsules have received substantial attention due to various potential applications for storage, catalysis, and drug delivery. However, their conventional enclosed non-/polycrystalline walls pose huge obstacles for rapid loading and mass diffusion. Here, the authors present a new single-crystal capsular-MOF with openings on the wall, which is carefully designed at the mol. level and constructed from a crystal-structure transformation. This rare open-capsule MOF can easily load the largest amounts of S and I among known MOFs. Derived from capsular-MOF and melamine through pyrolysis-phosphidation, the authors fabricated a N-doped capsular C-based framework with Fe-Ni phosphide nanoparticles immobilized on capsular carbons interconnected by plentiful carbon nanotubes. Benefiting from synergistic effects between the C framework and highly surface-exposed phosphide sites, the material exhibits efficient multifunctional electrocatalysis for O evolution, H evolution, and O reduction, achieving well-qualified assemblies of an overall H2O splitting (low potential of 1.59 V at 10 mA cm-2) and a rechargeable Zn-air battery (high peak power d. of 250 mW cm-2 and excellent stability for 500 h), which afford remarkably practical prospects over previously known electrocatalysts. In the experimental materials used by the author, we found 4-Acetylpyridine(cas: 1122-54-9Application In Synthesis of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Formula: C7H7NOIn 2020 ,《Design, Sonosynthesis, Quantum-Chemical Calculations, and Evaluation of New Mono- and Bis-pyridine Dicarbonitriles as Antiproliferative Agents》 appeared in Chinese Journal of Chemistry. The author of the article were Arafa, Wael Abdelgayd Ahmed; Hussein, Modather F.. The article conveys some information:

A highly efficient, simple, and clean single-step sonosynthetic procedure was sophisticated for assembling new series of mono- and bis-pyridine dicarbonitriles from ketones, HCl, and tetracyanoethylene. The presented protocol was applicable for the preparation of a broad range of uniquely substituted pyridine dicarbonitriles and were superior in comparison with other previously reported methods. The antiproliferative impact of the newly synthesized derivatives were screened towards three representative cancer cell lines (MCF-7, A549, and HCT116). Most of the evaluated derivatives showed a moderate to excellent anti-proliferative activity towards the selected cell lines. Of these, compounds I, II, III and IV [R = 2-pyridyl, 4-pyridyl] showed both potent anticancer activity (IC50 < 10μM) and lower cytotoxic effect (IC50 > 58μM) on non-tumorigenic cells (MCF-10A and NCM460), suggesting their promising potential to be lead mols. for future antitumor drug discovery. The structure-activity relationships was discussed. Moreover, quantum chem. studies based on d. functional theory (DFT) of the synthesized compounds were investigated and found to be consistent with the in-vitro inhibitory activities. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Formula: C7H7NO) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Huang, Zhiliang; Guan, Renpeng; Shanmugam, Muralidharan; Bennett, Elliot L.; Robertson, Craig M.; Brookfield, Adam; McInnes, Eric J. L.; Xiao, Jianliang published their research in Journal of the American Chemical Society in 2021. The article was titled 《Oxidative Cleavage of Alkenes by O2 with a Non-Heme Manganese Catalyst》.Synthetic Route of C7H7NO The article contains the following contents:

The oxidative cleavage of C=C double bonds with mol. oxygen to produce carbonyl compounds is an important transformation in chem. and pharmaceutical synthesis. In nature, enzymes containing the first-row transition metals, particularly heme and non-heme iron-dependent enzymes, readily activate O2 and oxidatively cleave C=C bonds with exquisite precision under ambient conditions. The reaction remains challenging for synthetic chemists, however. There are only a small number of known synthetic metal catalysts that allow for the oxidative cleavage of alkenes at an atm. pressure of O2, with very few known to catalyze the cleavage of nonactivated alkenes. In this work, we describe a light-driven, Mn-catalyzed protocol for the selective oxidation of alkenes to carbonyls under 1 atm of O2. For the first time, aromatic as well as various nonactivated aliphatic alkenes could be oxidized to afford ketones and aldehydes under clean, mild conditions with a first row, biorelevant metal catalyst. Moreover, the protocol shows a very good functional group tolerance. Mechanistic investigation suggests that Mn-oxo species, including an asym., mixed-valent bis(μ-oxo)-Mn(III,IV) complex, are involved in the oxidation, and the solvent methanol participates in O2 activation that leads to the formation of the oxo species. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Synthetic Route of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Synthetic Route of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Magri, Giuseppina; Folli, Andrea; Murphy, Damien M. published an article in European Journal of Inorganic Chemistry. The title of the article was 《Monitoring the Substrate-Induced Spin-State Distribution in a Cobalt(II)-Salen Complex by EPR and DFT》.Application of 1122-54-9 The author mentioned the following in the article:

Ground state changes of (R,R’)-N,N’-bis(3,5-di-tert-butylsalicylidene)-1,2-cyclohexane-diamino Co(II),following coordination of various pyridyl substrate has been examined by CW EPR, pulsed relaxation measurements and DFT. The solution-based Co(II) complex possesses a low spin (LS) state yz,2A2〉 (with g-values of 1.96, 1.895, 3.14). Upon coordination of the pyridyl substrate, the resulting bound adduct reveals a distribution of LS ‘base-on’ species, possessing a z2, 2A1〉 electronic ground state (with g-values of 2.008, 2.2145, 2.46) and a high spin (HS) species (with geff = 4.6). DFT indicated that the energy gap between the LS and HS state is dramatically lowered (ΔE < 25 kJmol-1) following substrate coordination. DFT suggests the main geometrical difference between the LS and HS systems is the severe puckering of the N2O2 ligand backbone. The results revealed a tentative dependency on the pKa-H of the substrates for the spin distribution where, in most cases, the higher pKa-H substrate values favored the HS species.4-Acetylpyridine(cas: 1122-54-9Application of 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application of 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Phosphine-NHC Manganese Hydrogenation Catalyst Exhibiting a Non-Classical Metal-Ligand Cooperative H2 Activation Mode》 were Buhaibeh, Ruqaya; Filippov, Oleg A.; Bruneau-Voisine, Antoine; Willot, Jeremy; Duhayon, Carine; Valyaev, Dmitry A.; Lugan, Noel; Canac, Yves; Sortais, Jean-Baptiste. And the article was published in Angewandte Chemie, International Edition in 2019. Name: 4-Acetylpyridine The author mentioned the following in the article:

Deprotonation of the MnI NHC-phosphine complex fac-[MnBr(CO)3(κ2P,C-Ph2PCH2NHC)] (2, II) under a H2 atmosphere readily gives the hydride fac-[MnH(CO)3(κ2P,C-Ph2PCH2NHC)] (3, III) via the intermediacy of the highly reactive 18-e NHC-phosphinomethanide complex fac-[Mn(CO)3(κ3P,C,C-Ph2PCHNHC)] (6a, VI). DFT calculations revealed that the preferred reaction mechanism involves the unsaturated 16-e mangana-substituted phosphonium ylide complex fac-[Mn(CO)3(κ2P,C-Ph2P=CHNHC)] (6 b) as key intermediate able to activate H2 via a non-classical mode of metal-ligand cooperation implying a formal λ5-P-λ3-P phosphorus valence change. Complex 2 is shown to be one of the most efficient pre-catalysts for ketone hydrogenation in the MnI series reported to date (TON up to 6200). In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《A combined computational/experimental study on HSA binding of two water-soluble Schiff base ligands derived from pyridine derivative and ethylendiamine》 were Molaee, Hajar; Sahihi, Mehdi; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Amiri Rudbari, Hadi. And the article was published in Journal of Biomolecular Structure and Dynamics in 2019. Name: 4-Acetylpyridine The author mentioned the following in the article:

In this paper, two water-soluble Schiff bases were synthesized by the reaction of 4-pyridinecarbaldehyde or 4-pyridylmethyl ketone with ethylenediamine. Then, the bidentate Schiff base compounds were characterized by 1H NMR spectroscopy and elemental anal. In addition, the mol. structure of one of these compounds was determined by single crystal X-ray diffraction technique. Then, the binding ability of these two Schiff bases with HSA was investigated using UV-vis and fluorescence spectroscopy, mol. docking, and mol. dynamics simulation methods. The experimental part of the paper was very detailed, including the reaction process of 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Electrochemical Reduction of the Carbonyl Functional Group: The Importance of Adsorption Geometry, Molecular Structure, and Electrode Surface Structure》 were Bondue, Christoph J.; Koper, Marc T. M.. And the article was published in Journal of the American Chemical Society in 2019. HPLC of Formula: 1122-54-9 The author mentioned the following in the article:

This paper studies the electrochem. hydrogenation of the carbonyl functional group of acetophenone and 4-acetylpyridine at platinum single-crystal electrodes. Comparison with results obtained for the hydrogenation of acetone featuring an isolated carbonyl functional group reveals the influence of the Ph ring and the pyridine ring, resp. Lack of acetone adsorption at Pt(111) and Pt(100) due to a weak interaction between surface and carbonyl functional group renders these surfaces inactive for the hydrogenation of acetone. Adsorption through a strong interaction with the Ph ring of acetophenone activates the Pt(111) and Pt(100) surfaces for hydrogenation of the acetyl substituent. In agreement with previous results for acetone reduction, the Pt(100) surface is specifically active for the hydrogenolysis reaction, breaking the C-O bond, whereas the other surfaces only hydrogenate the carbonyl functionality. In contrast to the Ph ring, the pyridine ring has a very different effect: due to the dominant interaction of the N atom of the pyridine ring with the platinum electrode, a vertical adsorption mode is realized. The resulting large phys. distance between the carbonyl functional group and the electrode surface inhibits the hydrogenation at all platinum surfaces. This also holds for the Pt(110) electrode, which is otherwise active for the electrochem. hydrogenation of the isolated carbonyl functional group of aliphatic ketones. Our results show how the combination of mol. structure of the reactant and surface structure of the catalyst determine the selective electroreduction of functionalized ketones.4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9) was used in this study.

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1122-54-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Efficient Transfer Hydrogenation of Ketones Catalyzed by a Phosphine-Free Cobalt-NHC Complex》 was written by Ibrahim, Jessica Juweriah; Reddy, C. Bal; Fang, Xiaolong; Yang, Yong. Computed Properties of C7H7NO And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A simple phosphine-free cobalt-NHC pincer complex was synthesized and used for the transfer hydrogenation of ketones with 2-propanol as hydrogen donor. A broad range of ketones varying from aromatic, aliphatic and heterocyclic were effectively reduced to their corresponding alcs. in moderate to excellent yields with good tolerance of functional groups. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Exploiting the umpolung reactivity of diazo groups: direct access to triazolyl-azaarenes from azaarenes》 was written by Devi, Lalita; Kumar, Prashant; Kant, Ruchir; Rastogi, Namrata. Name: 4-AcetylpyridineThis research focused ontriazolyl isoquinoline pyridine phenanthridine preparation; azaarene diazo iodonium triflate tandem electrophilic substitution dipolar cycloaddition. The article conveys some information:

The present work documents electrophilic substitution of azaarenes, mainly isoquinolines, with hypervalent iodine diazo reagents (HIDR) followed by formal [3+2]-dipolar cycloaddition in a tandem fashion. Other azaarenes viz. pyridines and phenanthridines too could be successfully used in the reaction. The methodol. capitalizes on the umpolung nature of α-aryliodonio diazo compounds for installing a nucleophile, i.e. azaarene, at their α-position. Subsequent ylide formation and intramol. 1,5-cyclization furnished 4,3-fused 1,2,4-triazolyl-azaarenes in good yields. The reaction is notable for its mild conditions, operational simplicity and fairly general scope. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Name: 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Name: 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem