Category: 1122-62-9

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 1122-62-9, Name is 1-(Pyridin-2-yl)ethanone. In a document, author is Wang, Qi, introducing its new discovery. Computed Properties of C7H7NO.

A novel potent inhibitor of 2-amino-l-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) formation from Chinese chive: Identification, inhibitory effect and action mechanism

Differential solvent extraction and phytochemical profiling of Chinse chive were employed to identify its principal PhIP-formation inhibitory constituents. Six compounds (mangiferin, isorhamnetin, luteolin, rosmarinic acid, 6-methylcoumarin, and cyanidin-3-glucoside) were further analyzed in a PhIP-producing chemical model to identify the dominant inhibitor. Its inhibitory mechanism was investigated by assessing the contribution of antioxidation and scavenging of key PhIP precursor/intermediate. No significant correlation was observed between PhIP inhibition rates and antioxidant activities. Further evaluation of the novel potent inhibitor mangiferin revealed a highly significant correlation between its dose-dependent inhibition of PhIP formation and phenylacetaldehyde scavenging. Finally, the proposed mechanism was corroborated through organic synthesis and structural elucidation of the mangiferin-phenylacetaldehyde adduct. This study has identified a potent novel inhibitor of the most abundant HA in heat-processed food and characterized its action mechanism. These findings may provide insight for future studies on mitigation of dietary exposure to toxic Maillard products by polyphenolic phytochemicals.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 1122-62-9 help many people in the next few years. Computed Properties of C7H7NO.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 1122-62-9, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 1122-62-9, Name is 1-(Pyridin-2-yl)ethanone, SMILES is C1=C(C(C)=O)N=CC=C1, belongs to pyridine-derivatives compound. In a article, author is Hsieh, Sheng-Ying, introduce new discover of the category.

Catalytic Enantioselective Pyridine N-Oxidation

The catalytic, enantioselective N-oxidation of substituted pyridines is described. The approach is predicated on a biomolecule-inspired catalytic cycle wherein high levels of asymmetric induction are provided by aspartic-acid-containing peptides as the aspartyl side chain shuttles between free acid and peracid forms. Desymmetrizations of bis(pyridine) substrates bearing a remote pro-stereogenic center substituted with a group capable of hydrogen bonding to the catalyst are demonstrated. Our approach presents a new entry into chiral pyridine frameworks in a heterocycle-rich molecular environment. Representative functionalizations of the enantioenriched pyridine N-oxides further document the utility of this approach. Demonstration of the asymmetric N-oxidation in two venerable drug-like scaffolds, Loratadine and Varenicline, show the likely generality of the method for highly variable and distinct chiral environments, while also revealing that the approach is applicable to both pyridines and 1,4-pyrazines.

Electric Literature of 1122-62-9, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1122-62-9.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 1122-62-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1122-62-9 as follows.

General procedure: A mixture of ketone (1 mmol), a known mole percent of the catalystand KOH (0.06 mmol) was dissolved in 2-propanol (5 mL), and the mixture was heated under reflux for the desired period oftime. The catalyst was removed as precipitate from the reactionmixture by the addition of diethyl ether followed by filtrationand subsequent neutralization with 5 mL of 1 M HCl. Then theether layer was passed through a short path of silica gel and the filtratewas subjected to GC analysis for identification andquantification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-62-9, its application will become more common.

Reference:
Article; Chowdhury, Nabanita Saha; Guharoy, Chhandasi; Butcher, Ray J.; Bhattacharya, Samaresh; Inorganica Chimica Acta; vol. 406; (2013); p. 20 – 26;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1122-62-9, 1-(Pyridin-2-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1122-62-9, blongs to pyridine-derivatives compound. 1122-62-9

General procedure: To a 25 mL Schlenk tube containing a solution of 1 in 2 mL of THF was added an aldehyde (1.0 mmol) and (EtO)3 SiH (0.20 g, 1.2 mmol). The reaction mixture was stirred at 50-55 C until there was no aldehyde left (monitored by TLC and GC-MS). The reaction was then quenched byMeOH (2mL) and a 10% aqueous solution of NaOH (5 mL) with vigorous stirring at 60 C for about 24 h.The organic product was extracted with diethyl ether (10 mL ¡Á 3), dried over anhydrous MgSO4, and concentrated under vacuum. The alcohol product was further purified using flash column chromatography (elute with 5-10% ethyl acetate in petroleum ether). The 1H NMR and 13C NMR spectra of the alcohol products are providedin Supporting information.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-62-9, its application will become more common.

Reference:
Article; Xue, Benjing; Sun, Hongjian; Niu, Qingfen; Li, Xiaoyan; Fuhr, Olaf; Fenske, Dieter; Catalysis Communications; vol. 94; (2017); p. 23 – 28;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1122-62-9, name is 1-(Pyridin-2-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. 1122-62-9

1-Pyridin-2-yl-ethanol 2-Acetylpyridine (1.0 g, 8.26 mmol) was dissolved in anhydrous methanol (20 mL) and treated with sodium borohydride (0.62 g, 16.51 mmol) and stirred at ambient temperature 18 hours. A saturated solution of ammonium chloride was added and the mixture was extracted with ethyl acetate. The combined organics were washed with water and brine, dried over anhydrous sodium sulfate, evaporated and chromatographed using a gradient of 50 to 100% ethyl acetate in hexanes to provide 0.57 g (56.1%) of the title compound. MS m/z 124 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1122-62-9, 1-(Pyridin-2-yl)ethanone, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc; US2009/170886; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

1122-62-9 , The common heterocyclic compound, 1122-62-9, name is 1-(Pyridin-2-yl)ethanone, molecular formula is C7H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(2-Bromoacetyl)pyridin-1-ium bromide (A): To a stuffed solution of 1-(pyridin-2- yl)ethan-1-one (2.0 g, 16.6 mmol) in Cd4 (60 ml), bromine (2.7 g, 16.60 mmol) was added dropwise. After complete addition the final reaction mixture was refluxed for 1 h. The precipitate was collected by filtration and washed 2-3 times with diethylether and dried to obtain compound A as a beige solid (2.94 g, 93%).

The synthetic route of 1122-62-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; VYOME BIOSCIENCES PVT. LTD.; SENGUPTA, Shiladitya; GHOSH, Shamik; GHOSH, Sumana; SINHA, Mau; SADHASIVAM, Suresh; BHATTACHARYYA, Anamika; MAVUDURU, Siva Ganesh; TANDON, Nupur; KUMAR, Deepak; (149 pag.)WO2017/17631; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem