Category: 1134-35-6

In 2019,Drug and Chemical Toxicology (1977) included an article by Varol, Mehmet; Benkli, Kadriye; Koparal, Ayse T.; Bostancioglu, Rakibe B.. Name: 4,4′-Dimethyl-2,2′-bipyridine. The article was titled 《Design and synthesis of novel organometallic complexes using boronated phenylalanine derivatives as potential anticancer agents》. The information in the text is summarized as follows:

Drug design and discovery studies are important because of the prevalence of diseases without available medical cures. New anticancer agents are particularly urgent because of the high mortality rate associated with cancer. A series of mononuclear gold (III) and platinum (II) complexes based on boronated phenylalanine (BPA) were designed and synthesized using 4,4′-dimethyl-2,2′-dipyridyl (L1) or 1,10-phenanthroline-5,6-dion (L2) ligands to obtain promising anticancer drug candidates. Proton NMR, IR, mass spectrometry, and elemental analyses were utilized for chem. characterizations. Cell viability, cancer cell colony formation, endothelial tube formation, and cytoskeleton staining assays were performed using A549 lung adenocarcinoma and human umbilical vein endothelial cells (HUVECs) to investigate preliminary pharmacol. activities. L1-based platinum (II) complex (BPA-L1-Pt) was the most promising complex, and has similar activity with the approved chemotherapy drug cis-platinum. Half maximal inhibitory concentration values for BPA-L1-Pt were 9.15 μM on A549s and 16.61 μM on HUVECs; the values for cis-platinum were 5.24 μM on A549s and 23.14 μM on HUVECs. Consequently, further synthesis studies should be performed to boost the cancer cell selectivity feature of BPA by varying metal and ligand types. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Xiao, Fengping; Wang, Hongkang; Yao, Tianhao; Zhao, Xin; Yang, Xuming; Yu, Denis Y. W.; Rogach, Andrey L. published their research in ACS Applied Materials & Interfaces in 2021. The article was titled 《MOF-Derived CoS2/N-Doped Carbon Composite to Induce Short-Chain Sulfur Molecule Generation for Enhanced Sodium-Sulfur Battery Performance》.Electric Literature of C12H12N2 The article contains the following contents:

Dissolution of intermediate sodium polysulfides (Na2Sx; 4≤x≤8) is a crucial obstacle for the development of room-temperature sodium-sulfur (Na-S) batteries. One promising strategy to avoid this issue is to load short-chain sulfur (S2-4), which could prohibit the generation of soluble polysulfides during the sodiation process. Herein, unlike in the previous reported cases where short-chain sulfur was stored by confinement within a small-pore-size (≤0.5 nm) carbon host, we report a new strategy to generate short-chain sulfur in larger pores (>0.5 nm) by the synergistic catalytic effect of CoS2 and appropriate pore size. Based on d. functional theory calculations, we predict that CoS2 can serve as a catalyst to weaken the S-S bond in the S8 ring structure, facilitating the formation of short-chain sulfur mols. By exptl. tuning the pore size of the CoS2-based hosts and comparing their performances as cathodes in Na-S and Li-S batteries, we conclude that such a catalytic effect depends on the proximity of sulfur to CoS2. This avoids the generation of soluble polysulfides and results in superior electrochem. properties of the composite materials introduced here for Na-S batteries. As a result, the optimized CoS2/N-doped carbon/S electrode showed excellent electrochem. performance with high reversible specific capacities of 488 mA h g-1 (962 mA h g(s)-1) after 100 cycles (0.1 A g-1) and 403 mA h g-1 after 1000 cycles (1 A g-1) with a superior rate performance (262 mA h g-1 at 5.0 A g-1). The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Electric Literature of C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Electric Literature of C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C12H12N2In 2019 ,《A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers》 was published in Bioorganic & Medicinal Chemistry. The article was written by Karges, Johannes; Heinemann, Franz; Maschietto, Federica; Patra, Malay; Blacque, Olivier; Ciofini, Ilaria; Spingler, Bernhard; Gasser, Gilles. The article contains the following contents:

The use of Photodynamic Therapy (PDT) for the treatment of several kinds of cancer as well as bacterial, fungal or viral infections has received increasing attention during the last decade. However, the currently clin. approved photosensitizers (PSs) have several drawbacks, including photobleaching, slow clearance from the organism and poor water solubility To overcome these shortcomings, many efforts have been made in the development of new types of PSs, such as Ru(II) polypyridyl complexes. Nevertheless, most studied Ru(II) polypyridyl complexes have a low absorbance in the spectral therapeutic window. In this work, we show that, by carefully selecting substituents on the polypyridyl complex, it is possible to prepare a complex absorbing at a much higher wavelength. Specifically, we report on the synthesis as well as in-depth exptl. and theor. characterization of a Ru(II) polypyridyl complex (complex 3) combining a shift in absorbance towards the spectral therapeutic window with a high 1O2 production To overcome the absence or poor selectivity of most approved PSs into targeted cells/bacteria, they can be linked to targeting moieties. In this line, compound 3 was designed with reactive aldehyde groups, which can be used as a highly versatile synthetic precursor for further conjugation. As a proof of concept, 3 was reacted with benzylamine and the stability of the resulting conjugate 4 was investigated in DMSO, PBS and cell media. 4 showed an impressive ability to act as a PDT PS with no measurable dark cytotoxicity and photocytotoxicity in the low micromolar range against cancerous HeLa cells from 450 nm up to 540 nm. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6COA of Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.COA of Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Name: 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Hierarchical CoS2/N-Doped Carbon@MoS2 Nanosheets with Enhanced Sodium Storage Performance》 was published in ACS Applied Materials & Interfaces. The article was written by Xiao, Fengping; Yang, Xuming; Wang, Hongkang; Yu, Denis Y. W.; Rogach, Andrey L.. The article contains the following contents:

We introduce a hierarchical nanostructure of CoS2/N-doped carbon@MoS2 comprising two transition-metal sulfides CoS2 and MoS2, with enhanced sodium storage performance in sodium-ion batteries. A micron-sized Co metal-organic framework (MOF) is transformed into a CoS2/N-doped carbon composite, followed by a solvothermal growth of MoS2 nanosheets on the surface. The resulting composite material offers several specific advantages for sodium storage: (i) accelerated sodium-ion diffusion kinetics due to its heterogeneous interface; (ii) shortened ion diffusion path and exposed active sites for sodium storage due to its hierarchical nanosheet architecture; and (iii) homogeneous nitrogen doping of the MOF-derived carbon, which is beneficial for electronic conductivity Due to these merits, this composite exhibits excellent electrochem. performance with a specific capacity of 596 mAh g-1 after 100 cycles at 0.1 A g-1 and 395 mAh g-1 at 5.0 A g-1.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《High in vitro and in vivo antitumor activities of Ln(III) complexes with mixed 5,7-dichloro-2-methyl-8-quinolinol and 4,4′-dimethyl-2,2′-bipyridyl chelating ligands》 were Meng, Ting; Qin, Qi-Pin; Chen, Zi-Lu; Zou, Hua-Hong; Wang, Kai; Liang, Fu-Pei. And the article was published in European Journal of Medicinal Chemistry in 2019. Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

Three novel Ln(III) complexes, namely, [Pm(dmbpy)(ClQ)2NO3] (1), [Yb(dmbpy)(ClQ)2NO3] (2), and [Lu(dmbpy)(ClQ)2NO3] (3), with mixed 5,7-dichloro-2-methyl-8-quinolinol (H-ClQ) and 4,4′-dimethyl-2,2′-bipyridyl (dmbpy) chelating ligands were 1st synthesized. The cytotoxic activity of Ln(III) complexes 1-3, H-ClQ, and dmbpy against a panel of human normal and cancer cell lines, namely, human nonsmall cell lung cancer cells (NCI-H460), human cervical adenocarcinoma cancer cells, human ovarian cancer cells, and human normal hepatocyte cells, were evaluated by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. The three novel Ln(III) complexes showed a high in vitro antitumor activity toward the NCI-H460 with IC50 of 1.00 ± 0.25 nM for 1, 5.13 ± 0.44 μM for 2, and 11.87 ± 0.79 μM for 3, resp. Ln(III) complexes 1 and 2 exerted their in vitro antitumor activity/mechanism mainly via the mitochondrial death pathway and caused a G2/M phase arrest in the following order: 1 > 2. An NCI-H460 tumor xenograft mouse model was used to evaluate the Pm(III) complex 1 in vivo antitumor activity. Pm(III) complex 1 showed a high in vivo antitumor activity, and the tumor growth inhibition rate (IR) was 56.0% (p < 0.05). In summary, the authors' study on Pm(III) complex 1 revealed promising results in vitro and in vivo antitumor activity assays. In the experiment, the researchers used 4,4'-Dimethyl-2,2'-bipyridine(cas: 1134-35-6Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Recommanded Product: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The author of 《Photoelectrochemical CO2 Reduction Using a Ru(II)-Re(I) Supramolecular Photocatalyst Connected to a Vinyl Polymer on a NiO Electrode》 were Kamata, Ryutaro; Kumagai, Hiromu; Yamazaki, Yasuomi; Sahara, Go; Ishitani, Osamu. And the article was published in ACS Applied Materials & Interfaces in 2019. SDS of cas: 1134-35-6 The author mentioned the following in the article:

A Ru(II)-Re(I) supramol. photocatalyst and a Ru(II) redox photosensitizer were both deposited successfully on a NiO electrode by using Me phosphonic acid anchoring groups and the electrochem. polymerization of the ligand vinyl groups of the complexes. This new mol. photocathode, poly-RuRe/NiO, adsorbed a larger amount of the metal complexes compared to one using only Me phosphonic acid anchor groups, and the stability of the complexes on the NiO electrode were much improved. The poly-RuRe/NiO acted as a photocathode for the photocatalytic reduction of CO2 at E = -0.7 V vs. Ag/AgCl under visible-light irradiation in an aqueous solution The poly-RuRe/NiO produced ∼2.5 times more CO, and its total faradaic efficiency of the reduction products improved from 57 to 85%. In the experiment, the researchers used many compounds, for example, 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6SDS of cas: 1134-35-6)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.SDS of cas: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Yang, Dongxu; Chen, Xiangyi; He, Dongsheng; Frommhold, Andreas; Shi, Xiaoqing; Boden, Stuart A.; Lebedeva, Maria A.; Ershova, Olga V.; Palmer, Richard E.; Li, Ziyou; Shi, Haofei; Gao, Jianzhi; Pan, Minghu; Khlobystov, Andrei N.; Chamberlain, Thomas W.; Robinson, Alex P. G. published an article in Journal of Physical Chemistry Letters. The title of the article was 《A Fullerene-Platinum Complex for Direct Functional Patterning of Single Metal Atom-Embedded Carbon Nanostructures》.Name: 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

The development of patterning materials (“”resists””) at the nanoscale involves two distinct trends-one is toward high sensitivity and resolution for miniaturization, the other aims at functionalization of the resists to realize bottom-up construction of distinct nanoarchitectures. Patterning of carbon nanostructures, a seemingly ideal application for organic functional resists, has been highly reliant on complicated pattern transfer processes due to a lack of patternable precursors. Here we present a fullerene-metal coordination complex as a fabrication material for direct functional patterning of sub-10 nm metal-containing carbon structures. The attachment of one platinum atom per fullerene mol. not only leads to significant improvement of sensitivity and resolution, but also enables stable at. dispersion of the platinum ions within the carbon matrix, which may gain fundamentally new interest in functional patterning of hierarchical carbon nanostructures. In the part of experimental materials, we found many familiar compounds, such as 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Name: 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Name: 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In 2022,Das, Sanjit; Nugegoda, Dinesh; Yao, Wenzhi; Qu, Fengrui; Figgins, Matthew T.; Lamb, Robert W.; Webster, Charles Edwin; Delcamp, Jared H.; Papish, Elizabeth T. published an article in European Journal of Inorganic Chemistry. The title of the article was 《Sensitized and Self-Sensitized Photocatalytic Carbon Dioxide Reduction Under Visible Light with Ruthenium Catalysts Shows Enhancements with More Conjugated Pincer Ligands》.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine The author mentioned the following in the article:

A new method to synthesize complexes of the type [(CNC)RuII(NN)L]n+ has been introduced, where CNC is a tridentate pincer composed of two (benz)imidazole derived NHC rings and a pyridyl ring, NN is a bidentate aromatic diimine ligand, L=bromide or acetonitrile, and n=1 or 2. Following this new method a series of six new complexes has been synthesized and characterized by spectroscopic, analytic, crystallog., and computational methods. Their electrochem. properties have been studied via cyclic voltammetry under both N2 and CO2 atmospheres. Photocatalytic reduction of CO2 to CO was performed using these complexes both in the presence (sensitized) and absence (self-sensitized) of an external photosensitizer. This study evaluates the effect of different CNC, NN, and L ligands in sensitized and self-sensitized photocatalysis. Catalysts bearing the benzimidazole derived CNC pincer show much better activity for both sensitized and self-sensitized photocatalysis as compared to catalysts bearing the imidazole derived CNC pincer. Furthermore, self-sensitized photocatalysis requires a diimine ligand for CO2 reduction with catalyst 2ACN being the most active catalyst in this series with TON=85 and TOF=22 h-1 with an electron donating 4,4′-dimethyl-2,2′-bipyridyl (dmb) ligand and a benzimidazole derived CNC pincer. In addition to this study using 4,4′-Dimethyl-2,2′-bipyridine, there are many other studies that have used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine) was used in this study.

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridineIn 2020 ,《Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted One- and Two-Photon Photodynamic Therapy》 appeared in ACS Applied Materials & Interfaces. The author of the article were Karges, Johannes; Li, Jia; Zeng, Leli; Chao, Hui; Gasser, Gilles. The article conveys some information:

Photodynamic therapy is a medical technique, which is gaining increasing attention to treat various types of cancer. Among the investigated classes of photosensitizers (PSs), the use of Ru(II) polypyridine complexes is gaining momentum. However, the currently investigated compounds generally show poor cancer cell selectivity. As a consequence, high drug doses are needed, which can cause side effects. To overcome this limitation, there is a need for the development of a suitable drug delivery system to increase the amount of PS delivered to the tumor. Herein, we report the encapsulation of a promising Ru(II) polypyridyl complex into polymeric nanoparticles with terminal biotin groups. Thanks to this design, the particles showed much higher selectivity for cancer cells in comparison to noncancerous cells in a 2D monolayer and 3D multicellular tumor spheroid model. As a highlight, upon i.v. injection of an identical amount of the Ru(II) polypyridine complex of the nanoparticle formulation, an improved accumulation inside an adenocarcinomic human alveolar basal epithelial tumor of a mouse up to a factor of 8.7 compared to the Ru complex itself was determined The nanoparticles were found to have a high phototoxic effect upon one-photon (500 nm) or two-photon (800 nm) excitation with eradication of adenocarcinomic human alveolar basal epithelial tumor inside a mouse model. Overall, this work describes, to the best of our knowledge, the first in vivo study demonstrating the cancer cell selectivity of a very promising Ru(II)-based PDT photosensitizer encapsulated into polymeric nanoparticles with terminal biotin groups. The experimental process involved the reaction of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridineIn 2022 ,《Syntheses, characterizations and structures of ruthenium carbene and allenylidene complexes supported by 1,4,7-trimethyl-1,4,7-triazacyclononane (Me3tacn) ligands》 was published in Journal of Organometallic Chemistry. The article was written by Qian, Bing-Feng; Gao, Yang; Xu, Qian-Ya; Jia, Ai-Quan; Shi, Hua-Tian; Zhang, Qian-Feng. The article contains the following contents:

Treatment of ruthenium(II) precursor [(Me3tacn)Ru(dmso)Cl2] (Me3tacn = 1,4,7-trimethyl-1,4,7-triazacyclononane, dmso = dimethylsulfoxide) (1) with concentrated HCl in the presence of air afforded the ruthenium(III) complex [(Me3tacn)RuCl3·H2O] (2), from which a series of bipyridine-ruthenium(II) complexes [(Me3tacn)Ru(R-bpy)(H2O)](PF6)2 (bpy = 2,2′-bipyridine) was obtained according to our previous work. Reactions of [(Me3tacn)Ru(R-bpy)(H2O)](PF6)2 and 1,1-diphenylpropargyl alc. afforded ruthenium(II) methoxycarbene complexes [(Me3tacn)(R-bpy)Ru:C(OMe)CH:CPh2](PF6)2 (3, 5, 7, 9; R = H, 4,4′-Me2, 5,5′-Me2, 4,4′-tBu2) and ruthenium(II) allenylidene complexes [(Me3tacn)(R-bpy)Ru:C:C:CPh2](PF6)2 (4, 6, 8, 10; R = H, 4,4′-Me2, 5,5′-Me2, 4,4′-tBu2) under different solvent conditions. Complexes 3-10 were well characterized by IR, UV/Vis, mass spectrometry, and NMR spectroscopies. The mol. structures of complexes 5, 7, and 8 have been also established by single-crystal X-ray diffraction. In the experimental materials used by the author, we found 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.Application In Synthesis of 4,4′-Dimethyl-2,2′-bipyridine Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem