Category: 1134327-98-2

Related Products of 1134327-98-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1134327-98-2, name is Ethyl 7-bromoimidazo[1,2-a]pyridine-3-carboxylate. A new synthetic method of this compound is introduced below.

Ethyl 7-hromoimidazo[i,2-ajpvridine-3-carhoxylate (0.100g. 0372 mmoi),aHyipaliadium chloride dimer (2.0 mg, 5.6 imo1), ROCKPHOS (5.2 mg, 0011 mmoi)and cesium carbonate (0.182 g, 0.557 mmol) were placed in a pressure vial. The reaction mixture was degassed (3x vacuumi?Ar), then toluene (2 rnL) was added, followed by the addition of 2-(pyrrolidin-i-yi)ethanol (0064 g, 0.56 mmol), The reaction mixture was degassed again, and stirred at 120 C for 5 Ii The reaction was cooled to rLTo thereaction was added water (1 mL) and LiOl-{ (50 mg). The reaction was heated at 6() Covernight. The solvents were removed. The crude product was purified by preparativeHPLC to afford Intermediate 34 (55 mg, 54 % yield), as a white solid. MS (ESI) in/z:276.0 (M±H). ?H NMR (400MHz. DMSO-d6) d 9.17 (d, J7.5 Hz, 1H), 7.33 (d, J2.4Hz, IH), 7.07 (d, J::::i.8 Hz, IFI), 7.02 (dd, J7.6, 2.5 Hz, IFI), 4.54-4.36 (m, 21-1), 3.86-2.93 (in, 6H), 2.06 (d, J:::90 Hz, 2H), 1.95 – 1.75 (iii. 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1134327-98-2, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SMITH II, Leon M.; LADZIATA, Vladimir; DELUCCA, Indawati; PINTO, Donald, J., P.; ORWAT, Michael J.; DILGER, Andrew K.; PABBISETTY, Kumar Balashanmuga; YANG, Wu; SHAW, Scott A.; GLUNZ, Peter W.; PANDA, Manoranjan; (612 pag.)WO2017/123860; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1134327-98-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1134327-98-2, name is Ethyl 7-bromoimidazo[1,2-a]pyridine-3-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Step 3: 7-Bromoimidazo[1 ,2-a]pyridine-3-carboxylicEthyl 7-bromoimidazo[1 ,2-a]pyridine-3-carboxylate (step 2)(30.81 g, 1 14 mmol) in MeOH (172 ml) was treated with 2M NaOH (172 ml, 343 mmol) and the mixture was heated to 60C for 40 minutes. The volatile solvent was removed in vacuo and the crude material was treated with 2M sodium bisulfate solution to adjust the pH to 6-7. The resulting solid was collected by filtrationand added to water (400 ml). The mixture was stirred and heated to 90C for 1 h. After cooling to RT, the suspension was filtered and dried in a vacuum over at 40C to afford the title product;LC-MS: Rt 0.59 mins; MS m/z 243.1 {M+H}+; Method 2minl_C_v003

According to the analysis of related databases, 1134327-98-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; IRM LLC; BRUCE, Ian; CHAMOIN, Sylvie; COLLINGWOOD, Stephen Paul; FURET, Pascal; FURMINGER, Vikki; LEWIS, Sarah; LOREN, Jon Christopher; MOLTENI, Valentina; SAUNDERS, Alex Michael; SHAW, Duncan; SVIRIDENKO, Lilya; THOMSON, Christopher; YEH, Vince; JANUS, Diana; WEST, Ryan; WO2013/30802; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem