Category: 113975-31-8

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 113975-31-8, name is N-(3-Iodopyridin-2-yl)pivalamide, molecular formula is C10H13IN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of N-(3-Iodopyridin-2-yl)pivalamide

3-Iodopyridin-2-amine N-(3-iodopyridin-2-yl)pivalamide (13.80 g, 45.36 mmole) was taken up in H2SO4 (24 wt. %, 394 ml) and the mixture was stirred for 60 minutes under reflux. After cooling to RT the mixture was neutralised with 4 N NaOH and solid NaHCO3, the aqueous phase was extracted with DCM (3*200 ml), and the combined organic phases were dried over MgSO4. After filtration, the solvent was removed on a rotary evaporator. 3-iodpyridin-2-amine (9.70 g, 97%) was obtained as a cream-coloured solid.

With the rapid development of chemical substances, we look forward to future research findings about 113975-31-8.

Reference:
Patent; GRUNENTHAL GMBH; US2009/156593; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 113975-31-8 ,Some common heterocyclic compound, 113975-31-8, molecular formula is C10H13IN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Manufacturing Example 1-2-3: 3-lodo-pyridin-2-ylamine N-(3-lodo-pyridin-2-yl)-2,2-dimethyl-propionamide (66.2 g, 218 mmol) described in Manufacturing Example 1-2-2, a 5 N aqueous solution (200 mL) of sodium hydroxide, and methanol (200 mL) were stirred under reflux for 1 hour and 20 minutes. The reaction solution was returned to room temperature, and then water was added thereto, which was extracted with ethyl acetate three times. The ethyl acetate layers were combined, which was washed once with saturated brine, and then dried over sodium sulfate. The sodium sulfate was removed by filtration, and the solvent was evaporated under a reduced pressure to obtain the titled compound (41 g). 1H-NMR spectrum (DMSO-d6) delta (ppm): 6.00 (2H, brs), 6.32 (1 H, dd, J = 4.8 Hz, 7.2 Hz), 7.87 (1 H, d, J = 7.2 Hz), 7.92 (1 H, d, J = 4.8 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113975-31-8, its application will become more common.

Reference:
Patent; Eisai R&D Management Co., Ltd.; EP2065377; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem