Category: 1149-23-1

Synthetic Route of 1149-23-1 , The common heterocyclic compound, 1149-23-1, name is Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate, molecular formula is C13H19NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Equivalent amounts of 1,4-dihydropyridine (1, 3 mmol) and cupricbromide (3 mmol) were taken in a dry round-bottomed flask (25 mL) and ethylacetate-chloroform mixture (10 ml, v/v 1:1) was added to it. The flask wasfitted with a Liebig condenser fitted with a calcium chloride guard tube andwas refluxed for 1 h. The reaction was monitored by TLC after an interval of10 min. After completion, the reaction mixture was filtered through a flutedfilter paper, washed thoroughly with chloroform in order to remove theadhering cuprous bromide from the product and dried over anhydrous Na2SO4.Solvent was removed in vacuo and purified by column filtration to get pureproduct.

The synthetic route of 1149-23-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Saikh, Forid; De, Rimpa; Ghosh, Somnath; Tetrahedron Letters; vol. 55; 45; (2014); p. 6171 – 6174;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1149-23-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1149-23-1, name is Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To the solution of HEH or BNAH (0.1 mmol) in ethanol or acetonitrile (2 mL) wasadded polysulfide 1 (0.2 mmol). The solution was incubated at r.t. or 37 C for 20 h(for HEH) or 5 h (for BNAH) under dark. After removing the solvent under reducedpressure, the yield of product 2 or 3 were determined by 1H-NMR.

According to the analysis of related databases, 1149-23-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Peng, Bo; Liu, Chunrong; Li, Zhen; Day, Jacob J.; Lu, Yun; Lefer, David J.; Xian, Ming; Bioorganic and Medicinal Chemistry Letters; vol. 27; 3; (2017); p. 542 – 545;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem