Category: 115170-40-6

Adding a certain compound to certain chemical reactions, such as: 115170-40-6, 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 115170-40-6, blongs to pyridine-derivatives compound. Recommanded Product: 115170-40-6

Intermediate IV andBromo-2,3-dihydro-1H-pyrrolo (2,3-b) pyridine to give d,React with (S) -3-hydroxytetrahydrofuran,A dark yellow solid VId was obtained.The intermediate d with activated carbon,Ferric chloride and hydrazine hydrate reduction,Obtained as an off-white solid VIId.Then VIId and diethyl phosphoric acid condensation,Compound VIIId is obtained,In the condensation with (dimethylamino) acetaldehyde diethyl acetal,The target compound was obtained. Yield: 48.7%.

The synthetic route of 115170-40-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Ouyang Yiqiang; Tang Qidong; Xu Shan; Tu Yuanbiao; Duan Yongli; Lei Huajun; Wang Caolin; (23 pag.)CN106831725; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine

A mixture of la (0.35 g, 1.76 mmol), 3-methoxybenzenesulfonyl chloride (0.37 mL, 2.64 mmol), and pyridine (3 mL) was refluxed overnight. The reaction was quenched with water and the mixture was extracted with ethyl acetate (30 ml x 3). The organic layer was collected, dried over anhydrous MgS04, and concentrated in vacuo to yield a brown residue, which was purified by a flash column over silica gel (ethyl acetate : n-hexane = 1 : 1 , Rf = 0.73) to afford 2c (0.56g, 86.17%) as a yellow solid. ‘H-NMR (500MHZ, CDCI3): delta 3.04 (t, /= 8.5 Hz, 2H), 3.84 (s, 3H), 4.07 (t, /= 8.5 Hz, 2H), 7.11 (dd, /= 2.5, 9.0 Hz, 1H), 7.38 (t, /= 8.0 Hz, 1H), 7.46 (s, 1H), 7.62 (dd, /= 1.5, 8.0 Hz, 1H), 7.65 (s, 1H), 8.19 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 115170-40-6.

Reference:
Patent; YEN, Yun; TAIPEI MEDICAL UNIVERSITY; NATIONAL HEALTH RESEARCH INSTITUTES; LIOU, Jing-Ping; CHANG, Jang-Yang; WANG, Jia-Yi; WO2015/157504; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 115170-40-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115170-40-6 as follows.

To a solution of 5-bromo-2,3-dihydro-1 H-pyrrolo(2,3-b)pyridine (CAS Number 1 15170-40-6; 0.300 g, 1 .507 mmol) in 1 ,4-dioxane:water (1 : 1 , 8 ml) were added phenylboronic acid (0.294 g, 2.412 mmol) and K2CO3 (0.624 g, 4.52 mmol) at rt. The reaction mixture was degassed for 30min before addition of Pd(PPh3)4 (0.087 g, 0.075 mmol) thenheated at 80C for 1 h. The reaction was cooled to rt, poured into water (100 ml) and extracted with EtOAc (3 x 50 ml). The combined organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure yielding 5-phenyl-2,3-dihydro-1 H-pyrrolo[2,3-b]pyridine (0.440 g, 2.24 mmol). MS: ES+ 197.1 .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115170-40-6, its application will become more common.

Reference:
Patent; MISSION THERAPEUTICS LIMITED; STOCKLEY, Martin Lee; KEMP, Mark Ian; MADIN, Andrew; (167 pag.)WO2018/65768; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 115170-40-6

In a microwave vial are combined l-ieri-butyl-2-(5-methoxy-2-pyrazol-l-yl-phenyl)-5- (4,4,5, 5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-benzimidazole (285 mg, 0.60 mmol), 5-bromo-2,3-dihydro-lH-pyrrolo[2,3-b]pyridine (100 mg, 0.50 mmol), potassium carbonate (140 mg, 1.0 mmol), and bis(di-ieri-butyl(4- dimethylaminophenyl)phosphine)dichloropalladium(II) (53 mg, 0.08 mmol) in toluene (3.0 mL) and water (0.30 mL). The reaction vial is sealed and stirred at 100 C for 4 hours in an oil bath. After this time the reaction is cooled and poured into water. The product is extracted into EtOAc (2x). The combined organics are dried (MgS04), filtered and concentrated. Purification via flash chromatography (12g silica gel, 0-5% MeOH/ CH2C12) affords the title compound (40 mg, 17%). LCMS (ESMS): m/z 465.20 (M++l)

The synthetic route of 115170-40-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; CHEN, Zhidong; HAO, Ming-Hong; LIU, Weimin; LO, Ho-Yin; LOKE, Pui Leng; MAN, Chuk, Chui; MORWICK, Tina, Marie; NEMOTO, Peter, Allen; TAKAHASHI, Hidenori; TYE, Heather; WU, Lifen; WO2011/68821; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 115170-40-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 1 (0.35 g, 1.76 mmol), 4-cyanobenzenesulfonyl chloride (0.39 g, 2.64 mmol), and pyridine (2 ml) was stirred at room temperature overnight. The reaction was quenched with water and the mixture was extracted with ethyl acetate (30ml*3). The organic layer was collected and dried over anhydrous MgS04, and concentrated in vacuo to yield a brown residue, which was purified by a flash column over silica gel (ethyl acetate: n-hexane = 1 : 1, Rf = 0.58) to afford 2n (0.35 g, 54.60%) as a yellow solid. *H-NMR (500MHz, CDC13): delta 3.09 (t, /= 8.5 Hz, 2H), 4.11 (t, /= 8.5 Hz, 2H), 7.50 (s, 1H), 7.79 (d, /= 8.5 Hz, 2H), 8.17 (s, 1H), 8.23 (d, /= 8.5 Hz, 2H).

According to the analysis of related databases, 115170-40-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YEN, Yun; TAIPEI MEDICAL UNIVERSITY; NATIONAL HEALTH RESEARCH INSTITUTES; LIOU, Jing-Ping; CHANG, Jang-Yang; WANG, Jia-Yi; WO2015/157504; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 115170-40-6 ,Some common heterocyclic compound, 115170-40-6, molecular formula is C7H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) 30g (0.151mol) of 5-bromo-7-azaporphyrin, 60g of activated carbon fiber catalyst, 264g of xylene into the reaction flask, stirring evenly, to obtain a reaction mixture G;b) The reaction mixture G at 100 C, oxygen flow 200mL/min, reaction 8h, chromatographic monitoring of the disappearance of raw materials;c) Filtration, filter out activated carbon fiber catalyst, obtain organic layer H, recover solvent, get 5-bromo-7-azaindole crude product, recrystallize from methanol to obtain product 25.37g, yield 85.43%, content ?99% .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 115170-40-6, 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhonggang Group Anshan Heat Energy Institute Co., Ltd.; Wang Haiyang; Wang Shoukai; Xu Zhe; Zhao Wei; Jiang Hui; Jin Dan; Xu Haoran; (7 pag.)CN107987076; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 115170-40-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 125 Step 1: (2,3-dihydro-lH-pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 5-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)-2,3-dihydro-lH-pyrrolo[2,3-b]pyridine To a stirred solution of 5-bromo-2,3-dihydro-lH-pyrrolo[2,3-b]pyridine (100 mg, 0.50 mmol) and 1 ,2-dimethoxyethane (4 mL) in a microwave vial equipped with a stirbar was added bis(pinacolato diborane) (175 mg, 0.65 mmol), potassium acetate (148 mg, 1.5 mmol) and 1,1′- bis(diphenylphosphino)ferrocene-palladium(II)dichloride (20.9 mg, 0.025 mmol). The mixture was purged with nitrogen gas for 5 min and the reaction mixture was stirred at 90 C for 5.5 h. The reaction mixture was filtered through a celite bed and washed with dichlorome thane (10 mL). The filtrate was concentrated to dryness in vacuo affording a crude mixture of (2,3-dihydro-lH- pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2,3- dihydro-lH-pyrrolo[2,3-b]pyridine used for the next step without any further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115170-40-6, 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 115170-40-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To the autoclave was added 100 kg of dihydro-5-bromo-7-azaindole, 100 kg of manganese dioxide and 950 kg of glacial acetic acid,Control the temperature of 80-90 degrees Celsius, reaction 2h, then the reaction solution cooled to 20 degrees Celsius, filtered, washed with water, centrifuged for 0.5 hours, dried product 5 – bromo-7-azaindole 82kg.

According to the analysis of related databases, 115170-40-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NANTONG ABA CHEMICALS CO., LTD.; WU, ZHENGGUANG; NIU, YUEHUI; LYU, JIAN; (5 pag.)CN106188050; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem