Category: 115473-15-9

115473-15-9 , The common heterocyclic compound, 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, molecular formula is C7H10ClNOS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To 4 mL of DMF was added compound 2 (0.20 g, 1.02 mmol), 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2 (4H)-one hydrochloride(5,6,7,7a-tetrahydrothieno[3,2-c] pyridin-2 (4H)-one hydrochloride, 0.29 ml, 1.53 mmol)1-ethyl-3-(3-dimethylaminopropyl)carbodiimide(1-ethyl-3-(3-dimethylaminopropyl)carbodiimide, 0.39 g, 2.04 mmol), N,N-diisopropylethylamine(N, N-diisopropylethylamine, a mixture of 0.36 mL, 2.04 mmol) in 40C was stirred for 4 hours. The mixture was concentrated under reduced pressure and purified by MPLC to give Oxo-DPide (1) in 10% yield.

According to the analysis of related databases, 115473-15-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Keimyung University; Seo Yeong-ho; (10 pag.)KR101937054; (2019); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. 115473-15-9

Example 16Purification of 5,6,7,7a-tetrahydro-4H-thieno [3,2-c]-pyridin-2-one hydrochloride Compound of Formula-12b50 gms of crude 5,6,7,7a-tetrahydro-4H-thieno [3,2-c]-pyridin-2-one hydrochloride compound of formula-12b obtained in example-15 is taken in methylene chloride (50 ml) and methanol (50 ml). Heated the reaction mixture to 40-45 C. and stirred for 30 min at same temperature. Cooled the reaction mixture to 25-30 C. and stirred for 1 hour. Filtered the solid and washed with methylene chloride. Dried the compound to get the pure title compoundYield: 45 gms.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride.

Reference:
Patent; Satyanarayana Reddy, Manne; Thirumalai Rajan, Srinivasan; Eswaraiah, Sajja; Rama Subba Reddy, Karamala; Kondal Reddy, Bairy; Venkat Reddy, Ghojala; US2012/202066; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

115473-15-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 115473-15-9, name is 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

The temperature was controlled at 10 to 15 C, 3000 ml of acetonitrile was added to the reaction flask, and 428 g (2.23 mol) of5,6,7,7a-tetrahydrothiophene [3,2-c] 2-pyridone hydrochloride, 1180 g of potassium hydrogencarbonate was slowly added, and then 488 g (2.05 mol) of intermediate 1 was mixed with 400 ml of acetonitrile The reaction mixture was stirred for 18-20 hours. The reaction was monitored by TLC. The solid was filtered off and the solid was removed. The filtrate was concentrated under reduced pressure to distill off the solvent. To the residue was added 1500 ml of ethyl acetate and 1500 ml of n-hexane And the mixture was stirred at 50-60 C for 2 hours. The mixture was filtered through hot filtration and the solid was discarded. The solvent was distilled off from the filtrate under reduced pressure. The residue was dissolved in 1500 ml of acetone, cooled to 5-10 C, and 40% hydrobromic acid 337 ml, The reaction mixture was stirred at 20-25 C for 3 h, cooled to 0-5 C, filtered and rinsed with 200 ml of acetone and dried in vacuo at 40 C for 2 h to give intermediate 2 (5- (alpha-cyclopropylcarbonyl -benzyl) -2-oxo-2,4,5,6,7,7a-hexahydrothieno (3,2-c) pyridine) in about 423 g, 45-60%

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride.

Reference:
Patent; Beijing Pharmaceutical Technology Development Co., Ltd.; li, jiao; zhao, bo; zhang, lei; (9 pag.)CN105503900; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

115473-15-9, Adding a certain compound to certain chemical reactions, such as: 115473-15-9, 5,6,7,7a-Tetrahydrothieno[3,2-c]pyridin-2(4H)-one hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 115473-15-9, blongs to pyridine-derivatives compound.

To a reaction flask equipped with a stirrer, a condenser and a thermometer was added 19.2 g of 5,6,7,7a-tetrahydrothieno[3,2-c]pyridin-2(4H)-one, which was then dispersed in 80 mL dichloromethane and cooled to 0 C. under stirring. 30.4 g of triethylamine were added to the mixture. After addition of 15.2 g of 3-cyanobenzyl bromide to the reaction system in batches, the reaction mixture was heated to reflux and continued to react for 5 h (completion of the reaction was monitored by TLC). The reaction liquid was washed with water (3¡Á80 mL). Then the dichloromethane layer was separated, fully dried over anhydrous sodium sulfate, and filtered. The dichloromethane was evaporated off under reduced pressure to obtain 20.8 g light yellow solid product (HPLC: 96.4%). Rf=0.45 [single point, developing solvent: v (petroleum ether): v (ethyl acetate)=1:2]. MS, m/Z: 270.0 (M).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115473-15-9, its application will become more common.

Reference:
Patent; TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH; LIU, Dengke; LIU, Ying; YUE, Nan; CHEN, Furong; TAN, Chubing; ZHOU, Yunsong; LIU, Peng; ZHAO, Yigui; ZHI, Deguang; LIU, Mo; LIU, Bingni; HUANG, Changjiang; TANG, Lida; US2013/72521; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem