Category: 1155847-42-9

Synthetic Route of 1155847-42-9, Adding some certain compound to certain chemical reactions, such as: 1155847-42-9, name is 2-Bromo-4-chloro-3-fluoropyridine,molecular formula is C5H2BrClFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1155847-42-9.

[00409] Intermediate 4 IB. 4-Chloro-3-fluoro-2-hydrazinylpyridine, 2HC1: In microwave vial was added toluene (3 mL) and purged with N2 for 5 min. tert-Butyl carbazate (128 mg, 0.950 mmol), Intermediate 101 A (200 mg, 0.950 mmol), Cs2C03 (310 mg, 0.950 mmol), DPPF (20 mg, 0.036 mmol), and Pd2(dba)3 (25 mg, 0.027 mmol) were added sequentially into the solution. The sealed tube was heated at 100 C for 12 h. The reaction was diluted with brine, and extracted with EtOAc (2x). The combined organic layer was concentrated in vacuo, yielding oily residue, which was purified by silica gel chromatography to provide tert-butyl 2-(4-chloro-3-fluoropyridin-2- yl)hydrazinecarboxylate (41 mg, 16%) as orange solid. MS(ESI) m/z: 262.1 (M+H) . To the solid was added EtOH (1 mL) and 4 N HCl in dioxane (4 mL) and the reaction mixture was stirred for 2 h at rt. The mixture was concentrated to dryness to the desired product. MS(ESI) m/z: 162.1 (M+H)+.

According to the analysis of related databases, 1155847-42-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; PINTO, Donald J.; CORTE, James R.; GILLIGAN, Paul J.; FANG, Tianan; SMITH II, Leon M.; WANG, Yufeng; YANG, Wu; EWING, William R.; WO2013/22818; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1155847-42-9, name is 2-Bromo-4-chloro-3-fluoropyridine, molecular formula is C5H2BrClFN, molecular weight is 210.43, as common compound, the synthetic route is as follows.Recommanded Product: 2-Bromo-4-chloro-3-fluoropyridine

To a degassed solution of 2-bromo-4-chloro-3-fluoropyridine (7.3g, 34.7 mmol) in DMF (50 mL) was added palladium tetrakistriphenylphosphine (4.01g, 3.47 mmol) and zinc cyanide (4.07g, 34.7 mmol) and heated to 1000C for 20 minutes. After this time, more palldium tetrakis triphenylphosphine (4.01g, 3.47mmol) was added and heated to 100C for 90 minutes. The mixture was allowed to cool to room temperature and treated with water (200 mL) and ether (400 mL). The resulting mixture was filtered to remove insoluble solids, the filtrate was partitioned, and the aqueous layer was extracted with ether (400 mL). The combined ether extracts were washed with water (200 mL), dried (MgSO4), filtered, and the solvent removed in vacuo. This residue was purified by chromatography using silica gel column (330 g) eluting with a gradient of 10-100% CH2CI2 in hexanes to provide the title compound. lH NMR (CDCI3) delta=8.45 (d, IH, J=5Hz) and 7.65 (dd, IH, J=5Hz) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1155847-42-9, 2-Bromo-4-chloro-3-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2009/67166; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1155847-42-9, name is 2-Bromo-4-chloro-3-fluoropyridine, molecular formula is C5H2BrClFN, molecular weight is 210.43, as common compound, the synthetic route is as follows.Recommanded Product: 2-Bromo-4-chloro-3-fluoropyridine

To a degassed solution of 2-bromo-4-chloro-3-fluoropyridine (7.3g, 34.7 mmol) in DMF (50 mL) was added palladium tetrakistriphenylphosphine (4.01g, 3.47 mmol) and zinc cyanide (4.07g, 34.7 mmol) and heated to 1000C for 20 minutes. After this time, more palldium tetrakis triphenylphosphine (4.01g, 3.47mmol) was added and heated to 100C for 90 minutes. The mixture was allowed to cool to room temperature and treated with water (200 mL) and ether (400 mL). The resulting mixture was filtered to remove insoluble solids, the filtrate was partitioned, and the aqueous layer was extracted with ether (400 mL). The combined ether extracts were washed with water (200 mL), dried (MgSO4), filtered, and the solvent removed in vacuo. This residue was purified by chromatography using silica gel column (330 g) eluting with a gradient of 10-100% CH2CI2 in hexanes to provide the title compound. lH NMR (CDCI3) delta=8.45 (d, IH, J=5Hz) and 7.65 (dd, IH, J=5Hz) ppm.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1155847-42-9, 2-Bromo-4-chloro-3-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2009/67166; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1155847-42-9, name is 2-Bromo-4-chloro-3-fluoropyridine. A new synthetic method of this compound is introduced below., SDS of cas: 1155847-42-9

Step-1: Preparation of tert-butyl (4-chloro-3-fluoropyridin-2-yl)carbamate To a solution of 2-bromo-4-chloro-3-fluoropyridine (825mg, 3.92mmol) in 1-4 Dioxane in a sealed tube (10ml) tert-butyl carbamate (505mg, 4.32mmol) and caesium carbonate (2.30g, 7.85mmol) and Pd(dba) (3350mg, 0.392mmol) and xanthphos (230mg, 0.392mmol) were added under argon and the reaction mixture was stirred at lOO C for 4h. The compound was extracted with ethyl acetate, dried over Na2S04 and concentrated to get crude compound which was purified by column chromatography using 20% EtOAC in hexane to obtain the title compound (450mg, 46.5%). LCMS: 63.4%, m/z = 247.0 (M+1)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1155847-42-9, 2-Bromo-4-chloro-3-fluoropyridine.

Reference:
Patent; GUMMADI Venkateshwar Rao; SAMAJDAR Susanta; WO2015/193846; A1; (2015);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem