Category: 1160791-13-8

Application of 1160791-13-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1160791-13-8, name is 2-Amino-6-bromothiazolo[5,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To 6-bromothiazoio[5,4-b]pyridin-2-amine (1 .1 g, 4.8 mmol) in acetonitriie (92 mL) was added copper(ll)chloride (964 mg, 7.2 mmol) and the mixture was cooled to OX. Tert- butyl nitrite (739 mg, 7.2 mmol) in acetonitriie (46 mL) was added slowly and the mixture was stirred for 30 minutes at Omicron’ and addit ional 4 hours at room temperature. The mixture was diluted with ethyl acetate, washed with saturated NH4CI-solution, with saturated sodium bicarbonate solution, brine and water. Evaporation yielded 580 mg (47 %) 6-bromo-2-chlorothiazolo[5,4-b]pyridine NMR (300 MHz, DMSO-cfe) delta = 7.87 (d, 1 H), 8.36 (d, 1 H) ppm.

According to the analysis of related databases, 1160791-13-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROeHN, Ulrike; SCHMITT-WILLICH, Heribert; HEINRICH, Tobias; BERGER, Markus; FITZNER, Ansgar; KRAUSE, Sabine; BROCKSCHNIEDER, Damian; DYRKS, Thomas; THIELE, Andrea; MOeNNING, Ursula; BOeMER, Ulf; WO2012/7510; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1160791-13-8, 2-Amino-6-bromothiazolo[5,4-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

General procedure: The mixture of 6-bromobenzo[d]thiazol-2-amine (2.0 g, 8.73 mmol), carbonyldimidazole (4.24 g, 26.2 mmol) and dried DMF (20 ml) was stirred at room temperature for 8 h, added cyclopropanamine (0.76 g, 13.2 mmol), then stirred at room temperature for another 8 h. The volatile was removed under reduced pressure. Water (30 ml) was added to the residue. The resulting suspension was stirred. After standing, the solid was collected by filtration, dried to produce 8a (1.77 g, 65%) as white solid. 4.1.1.9 1-(6-Bromothiazolo[5,4-b]pyridin-2-yl)-3-(2-(morpholinoethyl)urea (8i) White solid; Yield 86%; mp: 152-154 C; 1H NMR (DMSO-d6) delta 11.13 (s, 1H, NH), 8.01 (d, J = 8.3 Hz, 1H, Ar-H), 7.48 (d, J = 8.4 Hz, 1H, Ar-H), 6.81 (s, 1H, NH), 3.60 (s, 4H, OCH2*2), 3.29 (d, J = 5.2 Hz, 2H, CH2), 2.41 (s, 6H, NCH2*3). MS (ESI, m/z): Calcd for [M+H]+ C13H17BrN5O2S: 386, 388, found 386, 388.

The synthetic route of 1160791-13-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xie, Xiao-Xiao; Li, Huan; Wang, Juan; Mao, Shuai; Xin, Min-Hang; Lu, She-Min; Mei, Qi-Bing; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6477 – 6485;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1160791-13-8, Adding some certain compound to certain chemical reactions, such as: 1160791-13-8, name is 2-Amino-6-bromothiazolo[5,4-b]pyridine,molecular formula is C6H4BrN3S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1160791-13-8.

To a solution of 6-bromothiazolo[5,4-b]pyridin-2-amine IV (1.30 g, 5.55 mmol) in 1 ,4- dioxane (20.0 mL) was added ethylisocyanate (2.19 mL, 27.07 mmol) and the resulting reaction mixture was heated to 8O0C for 8 h. After the completion of the reaction (TLC monitoring), 1 ,4.-dioxane was distilled off followed by co-distillation with n-hexane (2 times). The residue was then stirred with water at 9O0C for 2h followed by filtration to obtain the desired product that was further washed with hot water and then dried. The residue was finally washed with ether to obtain the desired product (1.40 g, 83%). 1H NMR (400MHz, DMSO-d6): delta 1.10 (t, J= 7.20 Hz, 3H), 3.20 (quintet, J= 7.20 Hz, 2H), 6.76 (br s, 1 H), 8.24 (d, J= 2.0 Hz, 1 H), 8.45 (d, J= 2.0 Hz1 1 H) and 11.05 (br s, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1160791-13-8, 2-Amino-6-bromothiazolo[5,4-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PROLYSIS LTD; WO2009/74812; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1160791-13-8, Adding some certain compound to certain chemical reactions, such as: 1160791-13-8, name is 2-Amino-6-bromothiazolo[5,4-b]pyridine,molecular formula is C6H4BrN3S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1160791-13-8.

To a solution of 6-bromothiazolo[5,4-b]pyridin-2-amine IV (1.30 g, 5.55 mmol) in 1 ,4- dioxane (20.0 mL) was added ethylisocyanate (2.19 mL, 27.07 mmol) and the resulting reaction mixture was heated to 8O0C for 8 h. After the completion of the reaction (TLC monitoring), 1 ,4.-dioxane was distilled off followed by co-distillation with n-hexane (2 times). The residue was then stirred with water at 9O0C for 2h followed by filtration to obtain the desired product that was further washed with hot water and then dried. The residue was finally washed with ether to obtain the desired product (1.40 g, 83%). 1H NMR (400MHz, DMSO-d6): delta 1.10 (t, J= 7.20 Hz, 3H), 3.20 (quintet, J= 7.20 Hz, 2H), 6.76 (br s, 1 H), 8.24 (d, J= 2.0 Hz, 1 H), 8.45 (d, J= 2.0 Hz1 1 H) and 11.05 (br s, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1160791-13-8, 2-Amino-6-bromothiazolo[5,4-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PROLYSIS LTD; WO2009/74812; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1160791-13-8, name is 2-Amino-6-bromothiazolo[5,4-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Amino-6-bromothiazolo[5,4-b]pyridine

6-Bromo-[1 ,3]thiazolo[5,4-b]pyridin-2-amine (0.1 g, 0.43 mmol) was dissolved in N-methyl-2-pyrrolidone (1.5 mE) and ethyl 3-bromo-2-oxopropanoate (64 pi, 0.43 mmol) added dropwise. The reaction was stirred at room temperature for 1 hour then heated to 60 C. overnight. The reaction was cooled then water/ice added. The resulting precipitate was isolated by vacuum filtration. The red solid was further dried in a vacuum oven to give the title compound. ?H NMR(500 MHz, DMSO) 9.05 (s, 1H), 8.95 (d, J=2.1 Hz, 1H), 8.74 (d, J=2.1 Hz, 1H), 4.32 (q, J=7.1 Hz, 2H), 1.33 (t, J=7.1 Hz, 3H). Tr(MS10)=1.55 mi mlz (ES(M+H)328, 329

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1160791-13-8, 2-Amino-6-bromothiazolo[5,4-b]pyridine.

Reference:
Patent; CHDI Foundation, Inc.; Dominguez, Celia; Wityak, John; Bard, Jonathan; Brown, Christopher John; Prime, Michael Edward; Johnson, Peter David; Krulle, Thomas Martin; Clark-Frew, Daniel; Higgins, Duane; Mills, Matthew Robert; Marston, Richard Waldron; Coe, Samuel; Jones Green, Samantha Louise; Hayes, Sarah; (71 pag.)US2017/56535; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1160791-13-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1160791-13-8, name is 2-Amino-6-bromothiazolo[5,4-b]pyridine, molecular formula is C6H4BrN3S, molecular weight is 230.09, as common compound, the synthetic route is as follows.

Step 2: l-allyl-3- (6-bromothiazolo [5,4-b] pyridin-2-yl) urea (Intermediates). In a 25 ml round-bottomed flask, 6-bromothiazolo [5,4-b] pyridin-2-amine (0.575 g, 2.5 mmol) was suspended in tetrahydrofuran (15 mL). To this triethylamine (0.697 mL,5.00 mmol) was added in one portion and resulting reaction mixture was stirred at RT.Then allyl isocyanate (0.331 mL, 3.75 mmol) was added and stirred at RT for overnight.The reaction mixture was evaporated in vacuo, ice-cold water was added, sonicated well and the precipitated solid was filtered and dried under high vacuum. The crude product was triturated with acetonitrile gave the pure product as brown solid (0.650mg, 83%).MS (ES+): 314 for C10H9BrN4OS1H NMR (DMSO-d6) delta: 3.82 (t, 2H,CH2); 5.10 -5.25(m, 2H,CH2); 5.80 -5.95(m,IH5CH); 6.95 (t, IH5NH); 8.15 (bs, IH5NH); 8.23 (s, lH,Aro.); 8.48 (s, lH,Aro.).

The chemical industry reduces the impact on the environment during synthesis 1160791-13-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/147431; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem