Adding a certain compound to certain chemical reactions, such as: 116118-99-1, 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C8H10ClNO2S, blongs to pyridine-derivatives compound. Formula: C8H10ClNO2S
Synthesis Example 16c 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine 4,5,6,7-Tetrahydro-thieno[3,2-c]pyridine-2-carboxylic acid hydrochloride (260 mg, 1.2 mmol) was mixed with 47% hydrogen bromide aqueous solution (3 ml) and heated under reflux for 4 hours. The reaction solution was returned to room temperature and alkalified by adding sodium hydroxide aqueous solution (5 N), and the reaction product was extracted with diethyl ether, washed with saturated brine and then dried with anhydrous magnesium sulfate. By evaporating the solvent from the organic layer under a reduced pressure, 160 mg (1.1 mmol, 95% in yield) of the title compound was obtained. 1H-NMR (CDCl3): delta 2.80 (2H, t, J=5.6 Hz), 3.15 (2H, t), 3.93 (2H, t, J=1.7 Hz), 6.74 (1H, d, J=5.1 Hz), 7.07 (1H, d); MW 139.22 (C7H9NS); Mass spectrum EI-MS m/z 139 (M)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,116118-99-1, 4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Meiji Seika Kaisha, Ltd.; US6498251; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem