Category: 116308-38-4

Adding a certain compound to certain chemical reactions, such as: 116308-38-4, 2-Formylisonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Formylisonicotinonitrile, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Formylisonicotinonitrile

EXAMPLE 1 Preparation of 2-[N-methyl-N-(2-diphenylaminoethyl)amino]ethyl methyl 2,6-di-methyl-4-(4-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylate and monofumarate thereof A 50-ml eggplant type flask was charged with 1.003 g (7.59 mmol) of 4-cyano-2-pyridinealdehyde, 2.691 g (7.59 mmol) of 2-[N-methyl-N-(2-diphenylaminoethyl)amino]ethyl acetoacetate and 901 mg (7.59 mmol) of methyl 3-aminocrotonate. After addition of isopropanol (10 ml), the contents were dissolved therein. The flask was equipped with a Dimroth condenser and the solution was heated at 40 to 45 C. for 39 hours with agitation. The reaction solvent was tilled off under reduced pressure and the residue (6.175 g) was fractionated by column chromatography on silica gel (elution solvent: ethyl acetate/methanol=99:1). The resulting crude product was recrystallized from isopropyl ether/methanol so as to obtain a pale yellow powder of the desired compound in an amount of 2.219 g (yield: 59%). m.p. (after crystallization from isopropanol ether/methanol): 155.5 to 157 C. Pertinent IR and NMR data are as follows and are provided for each of the compounds and acid addition salts described in the following Examples as well. STR6 The above-obtained compound (2.090 g, 3.69 mmol) was placed in a 300-ml eggplant type flask. After addition of ethanol (168 ml), the contents were dissolved therein. Thereafter, fumaric acid (429 mg, 3.69 mmol) was added and the flask was equipped with an air-cooling tube. After continued agitation at room temperature for 1.5 hours, the reaction solvent was distilled off under reduced pressure to obtain a slightly yellow powder of a fumarate of the desired compound in an amount of about 2.5 g. STR7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,116308-38-4, 2-Formylisonicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Green Cross Corporation; US4910195; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116308-38-4, 2-Formylisonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 116308-38-4, blongs to pyridine-derivatives compound. Recommanded Product: 2-Formylisonicotinonitrile

General procedure: The E isomer of hydrazones 1-15 all can be easily to get by similar procedures. The corresponding aldehydes and hydrazine hydrochloride were added to the methanol solution, then the reaction mixture was heated under reflux for 10 h. After the reaction was finished, removed the solvent in vacuo. The residue was dissolved in water and neutralized with saturated NaHCO3 solution. Afterwards, extracted with dichloromethane and collected the organic layer. The organic layer were dried over by Na2SO4, filtered and concentrated. The residue was recrystallized by methanol to give the pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116308-38-4, its application will become more common.

Reference:
Article; Lu, Chaocao; Htan, Bu; Fu, Shitao; Ma, Chunmiao; Gan, Quan; Tetrahedron; vol. 75; 30; (2019); p. 4010 – 4016;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116308-38-4, 2-Formylisonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 2-Formylisonicotinonitrile, blongs to pyridine-derivatives compound. Application In Synthesis of 2-Formylisonicotinonitrile

EXAMPLE 1 Preparation of 2-[N-methyl-N-(2-diphenylaminoethyl)amino]ethyl methyl 2,6-di-methyl-4-(4-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylate and monofumarate thereof A 50-ml eggplant type flask was charged with 1.003 g (7.59 mmol) of 4-cyano-2-pyridinealdehyde, 2.691 g (7.59 mmol) of 2-[N-methyl-N-(2-diphenylaminoethyl)amino]ethyl acetoacetate and 901 mg (7.59 mmol) of methyl 3-aminocrotonate. After addition of isopropanol (10 ml), the contents were dissolved therein. The flask was equipped with a Dimroth condenser and the solution was heated at 40 to 45 C. for 39 hours with agitation. The reaction solvent was tilled off under reduced pressure and the residue (6.175 g) was fractionated by column chromatography on silica gel (elution solvent: ethyl acetate/methanol=99:1). The resulting crude product was recrystallized from isopropyl ether/methanol so as to obtain a pale yellow powder of the desired compound in an amount of 2.219 g (yield: 59%). m.p. (after crystallization from isopropanol ether/methanol): 155.5 to 157 C. Pertinent IR and NMR data are as follows and are provided for each of the compounds and acid addition salts described in the following Examples as well. STR6 The above-obtained compound (2.090 g, 3.69 mmol) was placed in a 300-ml eggplant type flask. After addition of ethanol (168 ml), the contents were dissolved therein. Thereafter, fumaric acid (429 mg, 3.69 mmol) was added and the flask was equipped with an air-cooling tube. After continued agitation at room temperature for 1.5 hours, the reaction solvent was distilled off under reduced pressure to obtain a slightly yellow powder of a fumarate of the desired compound in an amount of about 2.5 g. STR7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,116308-38-4, 2-Formylisonicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Green Cross Corporation; US4910195; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116308-38-4, 2-Formylisonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 116308-38-4, blongs to pyridine-derivatives compound. Recommanded Product: 2-Formylisonicotinonitrile

General procedure: The E isomer of hydrazones 1-15 all can be easily to get by similar procedures. The corresponding aldehydes and hydrazine hydrochloride were added to the methanol solution, then the reaction mixture was heated under reflux for 10 h. After the reaction was finished, removed the solvent in vacuo. The residue was dissolved in water and neutralized with saturated NaHCO3 solution. Afterwards, extracted with dichloromethane and collected the organic layer. The organic layer were dried over by Na2SO4, filtered and concentrated. The residue was recrystallized by methanol to give the pure product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116308-38-4, its application will become more common.

Reference:
Article; Lu, Chaocao; Htan, Bu; Fu, Shitao; Ma, Chunmiao; Gan, Quan; Tetrahedron; vol. 75; 30; (2019); p. 4010 – 4016;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 116308-38-4, Adding some certain compound to certain chemical reactions, such as: 116308-38-4, name is 2-Formylisonicotinonitrile,molecular formula is C7H4N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 116308-38-4.

Triethylamine (2.2 ml, 15 mmol) was added to a mixture of (3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phosphonic acid dimethyl ester (i)(2.4 g, 10.2 mmol) and (iid) (10.2 mmol) in tetrahydrofuran (10 ml). The reaction mixture was stirred for over 12 hours at 25C and concentrated in vacuo to yield 2-[3-oxo-3H-isobenzofuran-(1£,Z)-ylidenemethyl]-isonicotinonitrile (iii-int) as a red solid which was taken towards the next step without purification. (c) 2-(3-Oxo-3H-isobenzofuran-1-ylidenemethyl)-isonicotinonitrile (iii-int)To a cooled suspension (ca 0C) of [(3-Oxo-1,3-dihydro-isobenzofuran-1-yl)-phosphonic acid dimethyl ester] phosphonate (i)(8.0g, 33.0mmol) in THF (400mL) was added crude 2-formyl-isonicotinonitrile (iid)(30.0mmol) followed by triethylamine (6.2mL, 33.0mmol). The mixture was stirred for 30 minutes at 0C and then allowed to warm overnight.The reaction mixture was then evaporated in vacuo, the resultant solid was then washed with ethyl acetate (2 x 50ml_), methanol (1x 15mL) and then diethyl ether (2x 20mL). Two peaks were detected in LC-MS analysis, the desired product; m/z (LC-MS, ESP), RT=4.27mins, (M+H)=249.0, and an impurity peak (approx 40%)RT=4.47mins M+H 194). This material used without need for any purification.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 116308-38-4, 2-Formylisonicotinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2006/21801; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 116308-38-4, name is 2-Formylisonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Formylisonicotinonitrile

Part C To a flask charged with 70 ml of ether and 40 ml of tetrahydrofuran cooled in an ice bath at 0-50 is added methylmagnesium bromide (8.71 ml, 26.14 mmol, 1.50 equiv.) at once. To this is added a solution of 4-cyano-2-pyridinecarboxaldehyde (2.30 g, 17.42 mmol), dissolved in 60 ml of ether and 5 ml of tetrahydrofuran, dropwise over a 20 min period. The resulting tan slurry is refluxed for 1.5 h, cooled and poured into ice water containing 55 ml of 3N HCl and stirred at ambient temperature for 5 min. The contents are basified with 23 ml of 29% ammonium hydroxide and extracted 5 times with chloroform. The combined organic extracts are dried over Na2 SO4 and concentrated at reduced pressure. Chromatography with 160 g of silica gel, packed and eluted with acetone-methylene chloride (1:6), afforded 1.60 g (62%) of 4-cyano-2-(2-hydroxy)-ethylpyridine. TLC (silica gel GF): Rf =0.27 acetone-methylene chloride (1:6). 1 H NMR (CDCl3,TMS):delta 8.46 (d, 1H, J=4.33 Hz), 7.41 (s, 1H), 7.20 (dd, 1H, J=4.87, 0.82 Hz), 4.72 (q, 1H, J=6.08 Hz), 3.75 (s, 1H), 1.28 (d, 3H, J=6.55 UV (lambda max, ethanol): 216 sh (7,760), 220 sh (6,530), 278 (3,560), 287 sh (2,960). Analysis: Calculated for C8 H8 N2 O: C, 64.86; H, 5.41; N, 18.92. Found: C, 64.77; H, 5.51; N, 18.90. Mass Spectrum: M/Z (relative intensity %): (FAB) [M+H]+ 149 (100), 131 (30), 105 (8).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 116308-38-4, 2-Formylisonicotinonitrile.

Reference:
Patent; Pharmacia & Upjohn Company; US6043248; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem