Category: 116632-24-7

Application of 116632-24-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116632-24-7, name is 2-Amino-4,6-dichloropyridine. A new synthetic method of this compound is introduced below.

Reference Example 4 6-chloro-4-fluoropyridin-2-amine (0375) 7.46 g (49.11 mmol) of cesium fluoride were added at room temperature to a mixed solution of 2.00 g (12.27 mmol) of 4,6-dichloropyridin-2-amine and 30 ml dimethyl sulfoxide. After completion of the addition, said reaction mixture liquid was stirred for 12 hours at 170 C. After completion of the stirring, the reaction was stopped by addition of 100 ml of water, and said reaction liquid was extracted with ethyl acetate (2×300 ml). The organic layer obtained was dried with anhydrous sodium sulfate, and the solvent distilled off under reduced pressure. The residue obtained was purified by silica gel chromatography (n-hexane:ethyl acetate=9:1 to 5:5), and 95 mg of the desired compound were obtained as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116632-24-7, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; NAKAYA, Yoshihiko; MASUZAWA, Yoshihide; FURUHASHI, Takamasa; MIYAKADO, Yuuki; HOTTA, Hiroyasu; INABA, Masamitsu; (76 pag.)US2016/221998; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 116632-24-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116632-24-7, name is 2-Amino-4,6-dichloropyridine. A new synthetic method of this compound is introduced below.

Reference Example 7 4-chloro-6-phenoxypyridin-2-amine (0379) 630 mg (6.69 mmol) of phenol and 1.00 g (6.13 mmol) of 4,6-dichloropyridin-2-amine were added at room temperature to a mixed solution of 250 mg (6.56 mmol) of 63 wt. % sodium hydride (dispersion in mineral oil) and 15 ml dimethyl sulfoxide. After completion of the addition, said reaction mixture liquid was stirred for 14 hours at 100 C. After completion of the stirring, the reaction was stopped by addition of 30 ml of water, and said reaction liquid was extracted with diethyl ether (2×30 ml). The organic layer obtained was dried with anhydrous sodium sulfate, and the solvent distilled off under reduced pressure. The residue obtained was purified by silica gel chromatography (n-hexane:ethyl acetate=9:1 to 1:9), and 70 mg of the desired compound were obtained as a brown solid. (0380) 1H-NMR (CDCl3, Me4Si, 300 MHz): delta 7.44-7.35 (m, 2H), 7.21-7.18 (m, 1H), 7.13-7.09 (m, 2H), 6.19 (s, 1H), 6.08 (s, 1H), 4.52 (brs, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,116632-24-7, 2-Amino-4,6-dichloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; NAKAYA, Yoshihiko; MASUZAWA, Yoshihide; FURUHASHI, Takamasa; MIYAKADO, Yuuki; HOTTA, Hiroyasu; INABA, Masamitsu; (76 pag.)US2016/221998; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 116632-24-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116632-24-7, name is 2-Amino-4,6-dichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2,4-Dichloro-6-hydroxypyridine; Sodium nitrite (64 mg, 0.93 mmol) dissolved in water (0.6 mL), was added dropwise to a stirred solution of 2-amino-4,6-dichloropyridine (prepared according to the method described in Recl. Trav. Chim. Pays-Bas, 1950, 69, 673) (126 mg, 0.77 mmol) in 5% sulphuric acid (aq) (5 mL) at 0 C., over 5 min. The mixture was stirred at 0 C. for 1 h and then diluted with water (20 mL) and extracted with DCM (3×20 mL). The combined extracts were washed with brine (20 mL), dried over MgSO4 and concentrated in vacuo to afford the 2,4-dichloro-6-hydroxypyridine (116 mg, 0.71 mmol, 92%) M.S. (ESI) (m/z) 164,166 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 116632-24-7, 2-Amino-4,6-dichloropyridine.

Reference:
Patent; N.V. Organon; US2007/185156; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116632-24-7, 2-Amino-4,6-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 4,6-dichloropyridin-2-amine (2.0 g, 12.3 mmol), ethynylbenzene (2.51 g, 24.5 mmol), copper(I) iodide (234 mg, 1.23 mmol), Dichlorobis(triphenylphosphine)- palladium(II) (1.0 g, 1.23 mmol) and triethylamine (4.3 ml, 31 mmol) is stirred under argon atmosphere in ACN (20 ml) with THF (10 ml) for 6 h at 90C. The mixture is diluted with water and extracted with EtOAc. The combined organic layers are dried over MgS04, concentrated in vacuo and the product purified by NP chromatography. Yield: 1.2 g (43%). HPLC-MS: M+H=229; tR=l .96 min (*Method_2).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,116632-24-7, 2-Amino-4,6-dichloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; REISER, Ulrich; BADER, Gerd; SPEVAK, Walter; STEFFEN, Andreas; PARKES, Alastair L.; WO2013/127729; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116632-24-7, 2-Amino-4,6-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4,6-dichloropyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4,6-dichloropyridine

A mixture of 4,6-dichloropyridin-2-amine (2.0 g, 12.3 mmol), ethynylbenzene (2.51 g, 24.5 mmol), copper(I) iodide (234 mg, 1.23 mmol), Dichlorobis(triphenylphosphine)-palladium(II) (1.0 g, 1.23 mmol) and triethylamine (4.3 ml, 31 mmol) is stirred under argon atmosphere in ACN (20 ml) with THF (10 ml) for 6 h at 90 C. The mixture is diluted with water and extracted with EtOAc. The combined organic layers are dried over MgSO4, concentrated in vacuo and the product purified by NP chromatography. Yield: 1.2 g (43%). HPLC-MS: M+H=229; tR=1.96 min (*Method-2).

The synthetic route of 116632-24-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; REISER, Ulrich; BADER, Gerd; SPEVAK, Walter; STEFFEN, Andreas; PARKES, Alastair L.; US2013/225567; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 116632-24-7, 2-Amino-4,6-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Amino-4,6-dichloropyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2-Amino-4,6-dichloropyridine

A mixture of 2-amino-4,6-dichloropyridine (1.0 g, 6.1 mmol) and isopropylamine (5.0 mL. 61.1 mmol) was heated to 140 C in a microwave for 12h. The reaction was cooled to room temperature, concentrated and the crude residue was purified by FCC (40 g SiO2, 0 to 30% EtOAc : hexane) to afford 4-chloro-N2-isopropylpyridine-2,6-diamine (0.46 g, 40%). MS (ESI): mass calcd. for C8H12ClN3, 185.1; m/z found, 186.1 [M+H]+. 1H NMR (CDCl3): 5.80 (d, J = 1.4 Hz, 1H), 5.75 (d, J = 1.4 Hz, 1H), 4.28 – 4.18 (m, 3H), 3.77 – 3.67 (m, 1H), 1.19 (d, J = 6.4 Hz, 6H).To a solution of 4-chloro-N2-isopropylpyridine-2,6-diamine (100 mg, 0.54 mmol) in i-PrOH (1.0 mL) was added N-methylpiperazine (108 mg. 1.1 mmol) and ytterbium trifluoromethanesulfonate hydrate (378 mg. 0.59 mmol). The reaction was heated to 160 C in a microwave for 2h. The reaction was cooled to room temperature, concentrated and the crude residue was purified by FCC (12 g SiO2, 0 to 10% 2.0 M ammonia in MeOH : CH2Cl2) to afford the title compound 8a (30 mg, 22%). MS (ESI): mass calcd. for C13H23N5, 249.2; m/z found, 250.2 [M+H]+. 1H NMR (CDCl3): 5.36 (d, J = 1.8 Hz, 1H), 5.26 (d, J = 1.8 Hz, 1H), 4.07 – 3.95 (m, 3H), 3.77 – 3.65 (m, 1H), 3.28 – 3.20 (m, 4H), 2.54 – 2.45 (m, 4H), 2.32 (s, 3H), 1.19 (d, J = 6.3 Hz, 6H).

The synthetic route of 116632-24-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Meduna, Steven P.; Savall, Brad M.; Cai, Hui; Edwards, James P.; Thurmond, Robin L.; McGovern, Patricia M.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 10; (2011); p. 3113 – 3116;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem