Category: 1173897-86-3

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1173897-86-3, name is 5-Bromo-6-methylpicolinonitrile, molecular formula is C7H5BrN2, molecular weight is 197.032, as common compound, the synthetic route is as follows.Application In Synthesis of 5-Bromo-6-methylpicolinonitrile

A suspension of 5-bromo-6-methylpyridine-2-carbonitrile (CAS 1173897-86-3, 0.195 g, 0.990 mmol), PdCl2(dppf) (0.072 g, 0.099 mmol), Z>w(pinocolato)diboron (0.352g, 1.386 mmol) and potassium acetate (0.194 g, 1.979 mmol) in dry DMSO (1.979 mL) was degassed (vacuum / nitrogen cycles) and heated in a sealed tube at 90 C for 4 h. The mixture was diluted with EtOAc, washed sequentially with water and brine, dried (phase separator) and concentrated in vacuo. The resulting residue was purified by flash chromatography (0-30% EtOAc in petrol on Si02) to afford the title compound. MS ES+: 245

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1173897-86-3, 5-Bromo-6-methylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; AHMED, Saleh; BARKER, Gregory; CANNING, Hannah; DAVENPORT, Richard; HARRISON, David; JENKINS, Kerry; LIVERMORE, David; WRIGHT, Susanne; KINSELLA, Natasha; (259 pag.)WO2016/148306; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1173897-86-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1173897-86-3, name is 5-Bromo-6-methylpicolinonitrile, molecular formula is C7H5BrN2, molecular weight is 197.032, as common compound, the synthetic route is as follows.

An argon degassed solution of 5-bromo-6-methylpyridine-2-carbonitrile 13 (3.3 mmol, 650 mg), 4,4,5,5,-tetramethyl-2-vinyl-1,3,2-dioxaborolane (3.3 mmol, 0.56 mL), tetrakis(triphenylphosphine)palladium (5 mol %, 0.16 mmol, 190 mg) and 2N aqueous sodium carbonate solution (3.4 eq., 11.22 mmol, 5.60 mL) in toluene/ethanol (2:1, 45 mL) was heated at 95 C with stirring for 16 h. The slurry was cooled to RT, diluted with ethyl acetate and water. Organic layer was then separated. The organic layer was washed with brine and dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure to afford the desired product which was purified by flash chromatography over silica gel using an elution of 20% ethyl acetate in hexane to give 246 mg (Yield: 52%) of the title compound 14 as an oil. 1H NMR (400 MHz, CDCl3): delta 7.81 (1H, d, J = 8.0 Hz), 7.52 (1H, d, J = 8.0 Hz), 6.89 (1H, dd, J = 17.6 & 10.8 Hz), 5.79 (1H, d, J = 17.2 Hz), 5.58 (1H, d, J = 10.8 Hz), 2.62 (3H, s); ESI-MS: m/z 145 [M + H]+

Statistics shows that 1173897-86-3 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-6-methylpicolinonitrile.

Reference:
Article; Nino, Patricia; Caba, Marta; Aguilar, Nuria; Terricabras, Emma; Albericio, Fernando; Fernandez, Joan-Carles; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 55B; 9; (2016); p. 1117 – 1130;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1173897-86-3, 5-Bromo-6-methylpicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1173897-86-3, blongs to pyridine-derivatives compound. Recommanded Product: 5-Bromo-6-methylpicolinonitrile

5-Bromo-6-methylpicolinonitrile (0.080 g, 0.406 mmol), 9-( 1,1 -dimethyl- l-stannaethyl)-6,l l,4a-trihydromorpholino[4,3- e]pyrazino[2,3-b]pyrazin-5-one (0.150 g, 0.406 mmol), tris(dibenzylideneacetone)dipalladium(0) (0.041 g, 0.045 mmol), tri-o-tolylphosphine (0.027 g, 0.089 mmol) and triethylamine (0.170 mL, 1.219 mmol) were placed in a sealed tube and N,N-dimethylformamide (2 mL) was added. Nitrogen gas was bubbled through the reaction mixture for five minutes and the reaction sealed and heated at 100 0C for 1 h. The resulting cloudy black mixture was diluted with methanol, filtered and the filter cake washed thoroughly with methanol. The filtrate was concentrated under reduced pressure and purified using Biotage flash chromatography (50-100 % ethyl acetate in hexanes) to give the desired product (0.117 g, 0.363 mmol, 89 % yield). MS (ESI) m/z 323.5 [M+l]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1173897-86-3, its application will become more common.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; ELSNER, Jan; HARRIS, Roy, L.; LEE, Branden; MORTENSEN, Deborah; PACKARD, Garrick; PAPA, Patrick; PERRIN-NINKOVIC, Sophie; RIGGS, Jennifer; SANKAR, Sabita; SAPIENZA, John; SHEVLIN, Graziella; TEHRANI, Lida; XU, Weiming; ZHAO, Jingjing; PARNES, Jason; MADAKAMUTIL Loui; FULTZ Kimberly; NARLA, Rama K.; WO2010/62571; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem