Category: 1186647-69-7

Reference of 1186647-69-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1186647-69-7, name is 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H3ClIN3, molecular weight is 279.47, as common compound, the synthetic route is as follows.

To a solution of 4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine (2.00 g, 7.17 mmol) in DMF (30 mL) was added KOH (0.800 g, 14.3 mmol) and 1-(chloromethyl)-4-methoxybenzene (2.24 g, 14.3 mmol). The mixture was stirred at room temperature overnight. After concentration, the residue was purified by silica gel column chromatography eluting with petroleum ether/ethyl acetate (10:1 to 8:1) to give the title compound as a white solid (2.4 g, 82%).

The chemical industry reduces the impact on the environment during synthesis 1186647-69-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Estrada, Anthony; Shore, Daniel; Sweeney, Zachary; US2014/288043; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1186647-69-7, name is 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H3ClIN3, molecular weight is 279.47, as common compound, the synthetic route is as follows.HPLC of Formula: C6H3ClIN3

A mixture of 4-Chloro-3-iodo-lH-pyrazolo[4,3-c]pyridine (570.0 mg, 2.05 mmol, 1.0 eq), 3-chloro-6- (chloromethyl)quinoline (522.0 mg, 2.46 mmol, 1.2 eq) and KOH (230.0 mg, 4.1 mmol, 2.0 eq) in DMF (10.0 mL) was stirred at rt overnight. 30.0 mL of H20 was added and the mixture wasextracted with EA (15.0 mL X 3). The combined organic layers were washed with brine (15.0 mL X 3), dried over anhydrous Na2S04, then concentrated in vacuo. The resulting residue was purified by column chromatography to provide 3-chloro-6-((4- chloro-3-iodo-lH-pyrazolo[4,3-c]pyridin-l-yl)methyl)-7,8-dihydroquinoline (380 mg, 41%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1186647-69-7, 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (346 pag.)WO2018/11628; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1186647-69-7, 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A solution of 4-chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine (103) (50 mg, 0.179 mmol) in DMF (1 mL) was cooled to 0 C, NaH (8.6 mg, 1.2 eq, 0.215 mmol) was added slowly and then 2-bromopropane was added dropwise. The solution was stirred overnight at room temperature. The mixture was concentrated in vacuo. The crude product was then purified by column chromatography using a gradient of CH2Cl2 in hexanes to afford 4-chloro-3-iodo-1-isopropyl-1H-pyrazolo[4,3-c]pyridine (301) (30 mg, 53% yield) as a white solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1186647-69-7, 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Intellikine, LLC; LIU, Yi; REN, Pingda; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; (58 pag.)EP2252293; (2018); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1186647-69-7, name is 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine, molecular formula is C6H3ClIN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1186647-69-7

Intermediate 44-Chloro-3-iodo- 1-(4-methoxy-benzyl)~ 1 H-pyrazolo[4, 3-c]pyridine To a mixture of Intermediate 3 (1 g, 3.6 mmol) and KOH (0.3 mg, 5.4 mmol) in DMF (10 ml) at room temperature was added 4-methoxybenzyl chloride (0.5 ml, 3.6 mmol). The resulting mixture was stirred at room temperature for 2.5 h, and then evaporated to dryness. The crude residue was dissolved in EtOAc and washed with water. The organic phase was dried and purified by flash chromatography, eluting with 0 to 30% ethyl acetate/petroleum ether gradient to give a 9:1 mixture of regioisomers as a solid (1.3 g, 93%). Major regioisomer: 1H NMR (400 MHz, DMSO-dB) delta ppm 3.72 (s, 3 H), 5.62 (s, 2 H), 6.85 – 6.94 (m, 2 H), 7.20 – 7.27 (m, 2 H), 7.95 (d, J=6.0 Hz, 1 H), 8.20 (d, J=6.0 Hz, 1 H); m/z (ES+APCI)+: 400 [M + H]+.

With the rapid development of chemical substances, we look forward to future research findings about 1186647-69-7.

Reference:
Patent; MEDICAL RESEARCH COUNCIL TECHNOLOGY; GENENTECH INC.; CHAN, Bryan; CHEN, Huifen; ESTRADA, Anthony; SHORE, Daniel; SWEENEY, Zachary; McIVER, Edward; WO2012/38743; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1186647-69-7, name is 4-Chloro-3-iodo-1H-pyrazolo[4,3-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1186647-69-7

A suspension of 4-chloro-3-iodo-1H-pyrozolo[4,3-c]pyridine (7.88 g, 0.0280 mol) in DCM (100 mL) was stirred at 0 C. for 5 minutes. TEA (5.62 g, 0.0560 mol) was added and the mixture was stirred for 10 minutes. Trityl chloride (11.7 g, 0.0420 mol) was then added. After being stirred for 3 hours, the reaction mixture was treated with water (100 mL). The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated to give the title compound as an off-white solid (13.2 g, 89%).

With the rapid development of chemical substances, we look forward to future research findings about 1186647-69-7.

Reference:
Patent; Genentech, Inc.; Chan, Bryan; Estrada, Anthony; Shore, Daniel; Sweeney, Zachary; US2014/288043; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem