Category: 1187322-51-5

Application of 1187322-51-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1187322-51-5, name is 6-Amino-5-iodonicotinonitrile, molecular formula is C6H4IN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the degassed mixture of 6-amino-5-iodopyridine-3-carbonitrile (329 mg, 1 34 mmol), bis(triphenylphosphine)dichloropalladium(0) (95 mg, 0.134 mmol), Cul (128 mg, 0.671 mmol) and TEA (976 mg, 1.34 mL, 9.64 mmol) in absolute THF (18 mL), a propyne solution (3-4 % in THF; 13.2 mL) was added via septum at 0-5 C. The mixture was stirred for 30 minutes at 0-5 C, then for further 18 hours at room temperature. The reaction was quenched by the addition of NH4C1 solution. The solid was removed by filtration, and the cake was washed with CH2.CI2. The combined organic layer was dried over anhydrous Na2S()4, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica, eluted by 40 % EtOAc in cyclohexane to obtain 150 mg of 6- amino-5-(prop-l-yn-l-yl)pyridine-3-carbonitrile as a yellow solid (71 %).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1187322-51-5, 6-Amino-5-iodonicotinonitrile.

Reference:
Patent; RICHTER GEDEON NYRT.; LEDNECZKI, Istvan; ELES, Janos; TAPOLCSANYI, Pal; HORVATH, Anita; NEMETHY, Zsolt; LEVAY, Gyoergy Istvan; GALAMBOS, Janos; (0 pag.)WO2020/12424; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1187322-51-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1187322-51-5, name is 6-Amino-5-iodonicotinonitrile, molecular formula is C6H4IN3, molecular weight is 245.02, as common compound, the synthetic route is as follows.

To the solution of 3-iodo-5-isocyanopyridin-2-amine (2.74 g, 11.2 mmol, 1 eq) in anhydrous dimethylformamide (25 mL) in a 100 mL round bottom flask was added ammonium chloride (1.02 g, 1.7 eq) and sodium azide (1.24 g, 1.7 eq). The resulting reaction mixture was heated to 100 C. under nitrogen for 20 hours. After the reaction mixture was cooled to room temperature, it was poured into ice-chunk filled water and the pH of the mixture was adjusted to ?3.5 using aqueous hydrochloric acid (2 N). After the mixture was stirred at room temperature for about two hours, it was filtered through a Buchner funnel, rinsed with water, giving a brown solid. The solid was treated with MeOH-CHCl3 and concentrated down with silica gel. Upon gradient column chromatography (MeOH-EtOAc 1:20 to 1:5), 3-iodo-5-(2H-tetrazol-5-yl)pyridin-2-amine was obtained as off-white solid in the amount of 1.15 g. 1H NMR (600 MHz, DMSO-d6) delta ppm 8.60 (d, J=1.76 Hz, 1H) 8.45 (d, J=2.05 Hz, 1H) 6.77 (br. s., 2H).

Statistics shows that 1187322-51-5 is playing an increasingly important role. we look forward to future research findings about 6-Amino-5-iodonicotinonitrile.

Reference:
Patent; Allergan, Inc.; Boral, Sougato; Malone, Thomas C.; Wang, Shimiao; Rao, Sandhya; Yang, Rong; (28 pag.)US2016/102081; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1187322-51-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1187322-51-5, name is 6-Amino-5-iodonicotinonitrile. A new synthetic method of this compound is introduced below.

To the degassed mixture of 6-amino-5-(prop-l -yn-l-yl)pyridine-3-carbonitrile (329 mg, 1.34 mmol), bis'(triphenylphosphine)dichloropailadium(0) (95 mg, 0.134 mmol), copper (I) iodide (128 mg, 0.671 mmol) and triethylamine (976 mg, 1.34 mL, 9.64 mmol) in ahs. THF (18 mL) a propyn solution (3-4 % in THF; 13.2 mL) was added via septum at 0-5 C. The mixture was stirred for 30 minutes at 0-5 C, then for a further 18 hours at room temperature. The reaction was quenched by the addition of NFLCl solution. The solid was removed by filtration and the cake was washed with CH2CI2. The combined organic layer was dried with anhydrous NaiSOr, filtered and concentrated in vacuo. The crude product was purified by flash chromatography on silica, eluted by 40 % EtOAc in cyclohexane to give 150 mg of the title compound as a yellow solid (71 %).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1187322-51-5, 6-Amino-5-iodonicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; RICHTER GEDEON NYRT.; ELES, Janos; DUDASNE MOLNAR, Katalin; LEDNECZKI, Istvan; TAPOLCSANYI, Pal; HORVATH, Anita; NEMETHY, Zsolt; LEVAY, Gyoergy Istvan; (0 pag.)WO2020/12422; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1187322-51-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1187322-51-5, name is 6-Amino-5-iodonicotinonitrile, molecular formula is C6H4IN3, molecular weight is 245.02, as common compound, the synthetic route is as follows.

b) Synthesis of 6-amino-5-(4-fluorophenylethynyl)nicotinonitrile The iodine compound prepared above (300 mg), copper(I) iodide (20 mg) and caesium carbonate (1.7 g) are combined in a three-necked flask and dried at 100 C. in vacuo for 1 h. THF (50 ml), 1-ethyne-4-fluorobenzene (250 mg) and Pd(dppf)2Cl2*CH2Cl2 (78 mg) are subsequently added under nitrogen. The batch is stirred at 100 C., during which a black suspension forms. For work-up, the cooled reaction mixture is added to water and subsequently extracted with ethyl acetate. The organic phase is dried and evaporated. The residue is purified by chromatography, giving 220 mg of the title compound. HPLC [Rt] 3.31 min; [M+H]+238.

The chemical industry reduces the impact on the environment during synthesis 1187322-51-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GMBH; Heinrich, Timo; Rohdich, Felix; Esdar, Christina; Krier, Mireille; Greiner, Hartmut; US2015/218155; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1187322-51-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1187322-51-5, name is 6-Amino-5-iodonicotinonitrile, molecular formula is C6H4IN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1.2 g 5-[4-(6-trimethylsilanyl-hex-5-ynyl)-piperazin-1-yl]-benzofuran-2- carboxylic acid amide, 500 mg beta-amino-delta-iodo-nicotinonitrile, 0.1 g lithium chloride, 0.8 g sodium carbonate and 0.1 g 1,1′-bis(diphenyl- phosphino)ferrocenedichloropalladium- (II) dichloromethane adduct were dissolved in 50 ml DMF and heated for 12 h. The black suspension was poured on 50 ml water and extracted with ethyl acetate. After the usual extraction and purification procedure 20 mg of fawn amorphous solid 5-{4-[4-(5-cyano-1 H-pyrrolo[2,3-b]pyridine-3-yl)-butyl]- piperazin-1-yl}-benzofuran-2-carboxylic acid amide were obtained. 1H-NMR (500MHz, dbeta-DMSO) delta 12.18 (br s, 1H)1 8.49 (d, 1 H, J = 1.8 Hz), 8.33 (d, 1 H, J = 1.8 Hz), 7.99 (br. s, 1 H), 7.57 (br. s, 1 H), 7.47 (d, 1H1 J = 9.9 Hz), 7.40 (s, 1 H), 7.17 (m, 2H), 6.35 (s, 1 H), 3.33 (m, 4H), 3.11 (m, 4H)1 2.81 (m, 2H), 2.38 (m, 2H), 1.76 (m, 2H), 1.54 (m, 2H). P08033 HN.doc27HPLC-MS: Chromolite SpeedROD RP-18e 50-4, 6 mm solvent A: water + 0.1 % TFA solvent B: acetonitrile + 0.1% TFA 5 flow: 2.4 mL/min gradient: 0,0 min 4% B2.6 min 100% B Rt: 1.909 min[M+H]+: 398

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1187322-51-5, 6-Amino-5-iodonicotinonitrile.

Reference:
Patent; MERCK PATENT GMBH,; WO2009/112139; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1187322-51-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1187322-51-5, name is 6-Amino-5-iodonicotinonitrile, molecular formula is C6H4IN3, molecular weight is 245.02, as common compound, the synthetic route is as follows.

b) Synthesis of 6-amino-5-(4-fluorophenylethynyl)nicotinonitrile The iodine compound prepared above (300 mg), copper(I) iodide (20 mg) and caesium carbonate (1.7 g) are combined in a three-necked flask and dried at 100 C. in vacuo for 1 h. THF (50 ml), 1-ethyne-4-fluorobenzene (250 mg) and Pd(dppf)2Cl2*CH2Cl2 (78 mg) are subsequently added under nitrogen. The batch is stirred at 100 C., during which a black suspension forms. For work-up, the cooled reaction mixture is added to water and subsequently extracted with ethyl acetate. The organic phase is dried and evaporated. The residue is purified by chromatography, giving 220 mg of the title compound. HPLC [Rt] 3.31 min; [M+H]+238.

The chemical industry reduces the impact on the environment during synthesis 1187322-51-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK PATENT GMBH; Heinrich, Timo; Rohdich, Felix; Esdar, Christina; Krier, Mireille; Greiner, Hartmut; US2015/218155; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1187322-51-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1187322-51-5, name is 6-Amino-5-iodonicotinonitrile, molecular formula is C6H4IN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1.2 g 5-[4-(6-trimethylsilanyl-hex-5-ynyl)-piperazin-1-yl]-benzofuran-2- carboxylic acid amide, 500 mg beta-amino-delta-iodo-nicotinonitrile, 0.1 g lithium chloride, 0.8 g sodium carbonate and 0.1 g 1,1′-bis(diphenyl- phosphino)ferrocenedichloropalladium- (II) dichloromethane adduct were dissolved in 50 ml DMF and heated for 12 h. The black suspension was poured on 50 ml water and extracted with ethyl acetate. After the usual extraction and purification procedure 20 mg of fawn amorphous solid 5-{4-[4-(5-cyano-1 H-pyrrolo[2,3-b]pyridine-3-yl)-butyl]- piperazin-1-yl}-benzofuran-2-carboxylic acid amide were obtained. 1H-NMR (500MHz, dbeta-DMSO) delta 12.18 (br s, 1H)1 8.49 (d, 1 H, J = 1.8 Hz), 8.33 (d, 1 H, J = 1.8 Hz), 7.99 (br. s, 1 H), 7.57 (br. s, 1 H), 7.47 (d, 1H1 J = 9.9 Hz), 7.40 (s, 1 H), 7.17 (m, 2H), 6.35 (s, 1 H), 3.33 (m, 4H), 3.11 (m, 4H)1 2.81 (m, 2H), 2.38 (m, 2H), 1.76 (m, 2H), 1.54 (m, 2H). P08033 HN.doc27HPLC-MS: Chromolite SpeedROD RP-18e 50-4, 6 mm solvent A: water + 0.1 % TFA solvent B: acetonitrile + 0.1% TFA 5 flow: 2.4 mL/min gradient: 0,0 min 4% B2.6 min 100% B Rt: 1.909 min[M+H]+: 398

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1187322-51-5, 6-Amino-5-iodonicotinonitrile.

Reference:
Patent; MERCK PATENT GMBH,; WO2009/112139; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem