Synthetic Route of 1189757-62-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1189757-62-7, name is 5-Bromo-3-methoxypyridin-2(1H)-one, molecular formula is C6H6BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 1-(1-benzyl-5-methyl-1H-pyrazol-4-yl)-2-bromoethan- 1-one (200 mg), 5-bromo-3-methoxypyridin-2(1H)-one (139 mg), K2CO3 (189 mg), and DMSO (3.0 mL) was stirred at room temperature overnight. The mixture was quenched with water, and the resulting solid was collected by filtration and washed with DMSO/water (1:1), water, and isopropyl ether successively. The solid was recrystallized from DMSO/water to give the target compound (156 mg) as a solid. (1387) [00540] 1H NMR (500 MHz, CDCl3): ^ 8.05 (s, 1H), 7.39-7.30 (m, 3H), 7.17- 7.12 (m, 2H), 7.00 (d, J = 2.3 Hz, 1H), 6.71 (d, J = 2.3 Hz, 1H), 5.35 (s, 2H), 5.16 (s, 2H), 3.85 (s, 3H), 2.53 (s, 3H).
According to the analysis of related databases, 1189757-62-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HLA, Timothy; JILISHITZ, Irina; MEINKE, Peter; STAMFORD, Andrew; FOLEY, Michael; SATO, Ayumu; WADA, Yasufimi; FUKASE, Yoshiyuki; KINA, Asato; TAKAHAGI, Hiroki; IGAWA, Hideyuki; POLVINO, William J.; (0 pag.)WO2019/173790; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem